ID K7FI39_PELSI Unreviewed; 569 AA.
AC K7FI39;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Ring finger protein 180 {ECO:0000313|Ensembl:ENSPSIP00000007699.1};
GN Name=RNF180 {ECO:0000313|Ensembl:ENSPSIP00000007699.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000007699.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000007699.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01045484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01045485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01045486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01045487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01045488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01045489; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01045490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01045491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006117057.1; XM_006116995.2.
DR AlphaFoldDB; K7FI39; -.
DR Ensembl; ENSPSIT00000007740.1; ENSPSIP00000007699.1; ENSPSIG00000007080.1.
DR GeneID; 102459296; -.
DR CTD; 285671; -.
DR eggNOG; ENOG502QQJ8; Eukaryota.
DR GeneTree; ENSGT00950000182909; -.
DR HOGENOM; CLU_039803_0_0_1; -.
DR OMA; KNHNQEE; -.
DR OrthoDB; 3659878at2759; -.
DR TreeFam; TF328580; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0030534; P:adult behavior; IEA:Ensembl.
DR GO; GO:0042415; P:norepinephrine metabolic process; IEA:Ensembl.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
DR GO; GO:0042428; P:serotonin metabolic process; IEA:Ensembl.
DR CDD; cd16554; RING-HC_RNF180; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR033263; RNF180.
DR InterPro; IPR045790; RNF180_C.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR46717; E3 UBIQUITIN-PROTEIN LIGASE RNF180; 1.
DR PANTHER; PTHR46717:SF1; E3 UBIQUITIN-PROTEIN LIGASE RNF180; 1.
DR Pfam; PF19332; RNF180_C; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 543..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 409..451
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 569 AA; 65753 MW; 2A6991F5E8E3575B CRC64;
MNTLDADMLC CWKCRKYIAN SDCLIKYHGN QLFEKSHYSA VSQYTCNVWH MNLEALPDWV
KCAIEKAEWM IGKLNCPFCG ASLGGFNFVS NTKCSCGLFA NIHLCKSRID YQPACSVKLA
RSSVKHMSFC KVQSGFNNKI QHRMTGGILE PRNQRVSYMA ENMNGTGRLT EALCLEARSA
SFQMNSKKMH FKMYSKTKSH SASWPMNDKC TIKTCHRKAH SLDLNIREKF VLSSLYGVNS
KGPIYHRQNE IQPIYTRGSL QLESNRNNCF QGLYNSDTDE LTAKFSVTSC NTLTHRETEG
DCSFEASEQC AGSAPADQPP FVMDLFSSVS IVGEDIGQQH FTSVDLLQPT HFSMAAVNQN
LSKRERNKLK NLRKKQRKQE RWLQQKMLND NLDTDDEHEQ GGDKESYLCA VCLDVYFNPY
MCYPCHHIFC EPCLRMLAKD SPTNTPCPLC RTIIARVFFQ KELNDSTKSF FPTEYLKLKE
IFQKSSSAKW PLPSCKKPFR VYEGFPRHTD PVTRRHFPHA AHRMDYMDFE DDSRGWWFDM
DMVIIYIYSV NWVIGFIVFC FLCYLFFPF
//
