ID K7FIY3_PELSI Unreviewed; 1104 AA.
AC K7FIY3;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 24-JAN-2024, entry version 71.
DE SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 {ECO:0000313|Ensembl:ENSPSIP00000007993.1};
GN Name=ARAP1 {ECO:0000313|Ensembl:ENSPSIP00000007993.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000007993.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000007993.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGCU01115945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115949; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FIY3; -.
DR STRING; 13735.ENSPSIP00000007993; -.
DR Ensembl; ENSPSIT00000008035.1; ENSPSIP00000007993.1; ENSPSIG00000006969.1.
DR eggNOG; KOG1117; Eukaryota.
DR GeneTree; ENSGT00940000157424; -.
DR HOGENOM; CLU_002900_1_1_1; -.
DR OMA; QTELREW; -.
DR TreeFam; TF105769; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR GO; GO:0051497; P:negative regulation of stress fiber assembly; IEA:Ensembl.
DR GO; GO:0051491; P:positive regulation of filopodium assembly; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd17901; ArfGap_ARAP1; 1.
DR CDD; cd13253; PH1_ARAP; 1.
DR CDD; cd13254; PH2_ARAP; 1.
DR CDD; cd13259; PH5_ARAP; 1.
DR CDD; cd17226; RA_ARAP1; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR45899:SF3; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 3.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 5.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 5.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 5.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 3..95
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 117..206
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 212..337
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 420..530
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 541..630
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 634..824
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 828..917
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 930..1051
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 1104 AA; 126903 MW; 9797698EA9843797 CRC64;
LSPIIKAGWL DKNPPQGSYI YQKRWVKLDA DYLRYFDSEK DTYSKRFIPV SSISRVASIG
DQKFEVITNH RTFAFRAESD ADRNEWMRTF QQMVDEQKFR GLNRISLFQP ANGILDMVDK
CGLLELRGFK NKLYVVVSGD KVFLYKNAED FRQGIGITYI EMNVGNVKDV DRRGFDLTTP
YKIFSFWADS DQEKDEWVEA MQQSIAEALS NSEVAEKIWS VEANRFCADC GSPNPDWASV
NLCVVICKRC AGEHRGLGPS ITKVRSLKMD RKVWTEELIE LFCQVGNGVA KQFWAANVPP
SEAIHPASGS QERRRFLVAK YKEGKYRRYH PLFGNQEELN KALCATVTTS DVAETQSLVF
CGAEVSCNSG DPDFPTPTAI AEQAGQRLQM EFLLQNKNSE IPRVETGSSA EKHYSVVLPS
VTHNGFLYKT PSPHSRWQRR RKASPPIEFS RRWCTLNDSI FSYYENDRSP APNGELKMEE
IVCLVNNPPD THGFESTFEV CIESERLYLF GLDNPEAVRK WVKSIAKSFI PPHVEELLSH
DFERIGRLQY KGGLNLERAK EGWFALAQGT LYAFFEDSDQ EEALHLKKLQ ELSIQGDSLV
LVERRRTLYI QGERKLDFSG WVAAIQKAAG SSGDTLSEQQ LTESDIPVIV DRCIDYITQC
GLTSEGIYRE RGQKLKTTAR RVRLKEGEHQ VDDVSNTLKR FFRDLGDGLF TKDHCQDWLK
AAAIEDEEEK IGQYRQLLGS LPMVNRATLK ALINHLYRVQ YFSNMNQMNT HNLAIVFGPT
LCVVEDLISH YVVIFNVDEQ EMRKQQDEIT AIIKMRIAGS SSGTQQAGDF ICTVYLEEKR
TEAEQHVKIP ATMTAEELTF EILDRRKMVM REKEYWSCFE VNEREEAERP LHYSEKVLPI
VHCLGTDSYL VVKKQLSMEN MLIYLASRVG DSKHGMMKFR EERNLLGLGL STGFHDRYFI
LNQSCLRLYK EVRHRIPLGG RVELSHRPEK EWPVKNLKVF LGVKKKLRPP SCWGFTVFYE
NEKHEKQQWY LCCDTQMEMR EWFATFLYVQ NGGNIWPSES SKVRASRTQQ DSRLGNISLI
PLRGNENEMR NSVAAFAADP LTLL
//