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Database: UniProt
Entry: K7FIY3_PELSI
LinkDB: K7FIY3_PELSI
Original site: K7FIY3_PELSI 
ID   K7FIY3_PELSI            Unreviewed;      1104 AA.
AC   K7FIY3;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   24-JAN-2024, entry version 71.
DE   SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 {ECO:0000313|Ensembl:ENSPSIP00000007993.1};
GN   Name=ARAP1 {ECO:0000313|Ensembl:ENSPSIP00000007993.1};
OS   Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC   Trionychidae; Pelodiscus.
OX   NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000007993.1, ECO:0000313|Proteomes:UP000007267};
RN   [1] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG   Soft-shell Turtle Genome Consortium;
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA   White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA   Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA   Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA   Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT   into the development and evolution of the turtle-specific body plan.";
RL   Nat. Genet. 45:701-706(2013).
RN   [3] {ECO:0000313|Ensembl:ENSPSIP00000007993.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; AGCU01115945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01115946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01115947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01115948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01115949; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01115950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01115951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; K7FIY3; -.
DR   STRING; 13735.ENSPSIP00000007993; -.
DR   Ensembl; ENSPSIT00000008035.1; ENSPSIP00000007993.1; ENSPSIG00000006969.1.
DR   eggNOG; KOG1117; Eukaryota.
DR   GeneTree; ENSGT00940000157424; -.
DR   HOGENOM; CLU_002900_1_1_1; -.
DR   OMA; QTELREW; -.
DR   TreeFam; TF105769; -.
DR   Proteomes; UP000007267; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR   GO; GO:0051497; P:negative regulation of stress fiber assembly; IEA:Ensembl.
DR   GO; GO:0051491; P:positive regulation of filopodium assembly; IEA:Ensembl.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd17901; ArfGap_ARAP1; 1.
DR   CDD; cd13253; PH1_ARAP; 1.
DR   CDD; cd13254; PH2_ARAP; 1.
DR   CDD; cd13259; PH5_ARAP; 1.
DR   CDD; cd17226; RA_ARAP1; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR45899:SF3; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF00169; PH; 3.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 5.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 5.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 5.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN          3..95
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          117..206
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          212..337
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   DOMAIN          420..530
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          541..630
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          634..824
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   DOMAIN          828..917
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   DOMAIN          930..1051
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
SQ   SEQUENCE   1104 AA;  126903 MW;  9797698EA9843797 CRC64;
     LSPIIKAGWL DKNPPQGSYI YQKRWVKLDA DYLRYFDSEK DTYSKRFIPV SSISRVASIG
     DQKFEVITNH RTFAFRAESD ADRNEWMRTF QQMVDEQKFR GLNRISLFQP ANGILDMVDK
     CGLLELRGFK NKLYVVVSGD KVFLYKNAED FRQGIGITYI EMNVGNVKDV DRRGFDLTTP
     YKIFSFWADS DQEKDEWVEA MQQSIAEALS NSEVAEKIWS VEANRFCADC GSPNPDWASV
     NLCVVICKRC AGEHRGLGPS ITKVRSLKMD RKVWTEELIE LFCQVGNGVA KQFWAANVPP
     SEAIHPASGS QERRRFLVAK YKEGKYRRYH PLFGNQEELN KALCATVTTS DVAETQSLVF
     CGAEVSCNSG DPDFPTPTAI AEQAGQRLQM EFLLQNKNSE IPRVETGSSA EKHYSVVLPS
     VTHNGFLYKT PSPHSRWQRR RKASPPIEFS RRWCTLNDSI FSYYENDRSP APNGELKMEE
     IVCLVNNPPD THGFESTFEV CIESERLYLF GLDNPEAVRK WVKSIAKSFI PPHVEELLSH
     DFERIGRLQY KGGLNLERAK EGWFALAQGT LYAFFEDSDQ EEALHLKKLQ ELSIQGDSLV
     LVERRRTLYI QGERKLDFSG WVAAIQKAAG SSGDTLSEQQ LTESDIPVIV DRCIDYITQC
     GLTSEGIYRE RGQKLKTTAR RVRLKEGEHQ VDDVSNTLKR FFRDLGDGLF TKDHCQDWLK
     AAAIEDEEEK IGQYRQLLGS LPMVNRATLK ALINHLYRVQ YFSNMNQMNT HNLAIVFGPT
     LCVVEDLISH YVVIFNVDEQ EMRKQQDEIT AIIKMRIAGS SSGTQQAGDF ICTVYLEEKR
     TEAEQHVKIP ATMTAEELTF EILDRRKMVM REKEYWSCFE VNEREEAERP LHYSEKVLPI
     VHCLGTDSYL VVKKQLSMEN MLIYLASRVG DSKHGMMKFR EERNLLGLGL STGFHDRYFI
     LNQSCLRLYK EVRHRIPLGG RVELSHRPEK EWPVKNLKVF LGVKKKLRPP SCWGFTVFYE
     NEKHEKQQWY LCCDTQMEMR EWFATFLYVQ NGGNIWPSES SKVRASRTQQ DSRLGNISLI
     PLRGNENEMR NSVAAFAADP LTLL
//
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