ID K7FJH8_PELSI Unreviewed; 446 AA.
AC K7FJH8;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Transcription factor {ECO:0000256|PIRNR:PIRNR009404};
GN Name=TFDP2 {ECO:0000313|Ensembl:ENSPSIP00000008188.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000008188.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000008188.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR009404,
CC ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|PIRNR:PIRNR009404,
CC ECO:0000256|RuleBase:RU003796}.
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DR EMBL; AGCU01093030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01093031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01093032; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01093033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01093034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01093035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01093036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01093037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01093038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01093039; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006124056.1; XM_006123994.1.
DR AlphaFoldDB; K7FJH8; -.
DR STRING; 13735.ENSPSIP00000008188; -.
DR Ensembl; ENSPSIT00000008231.1; ENSPSIP00000008188.1; ENSPSIG00000007519.1.
DR GeneID; 102460347; -.
DR KEGG; pss:102460347; -.
DR CTD; 7029; -.
DR eggNOG; KOG2829; Eukaryota.
DR GeneTree; ENSGT00940000157909; -.
DR HOGENOM; CLU_039874_3_1_1; -.
DR OMA; GXKRSKK; -.
DR OrthoDB; 1343784at2759; -.
DR TreeFam; TF314396; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR CDD; cd14458; DP_DD; 1.
DR Gene3D; 1.20.140.80; Transcription factor DP; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR037241; E2F-DP_heterodim.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR038168; TF_DP_C_sf.
DR InterPro; IPR014889; Transc_factor_DP_C.
DR InterPro; IPR015648; Transcrpt_fac_DP.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12548; TRANSCRIPTION FACTOR DP; 1.
DR PANTHER; PTHR12548:SF5; TRANSCRIPTION FACTOR DP-2; 1.
DR Pfam; PF08781; DP; 1.
DR Pfam; PF02319; E2F_TDP; 1.
DR PIRSF; PIRSF009404; Transcription_factor_DP; 1.
DR SMART; SM01138; DP; 1.
DR SMART; SM01372; E2F_TDP; 1.
DR SUPFAM; SSF144074; E2F-DP heterodimerization region; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|PIRNR:PIRNR009404, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|PIRNR:PIRNR009404, ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Transcription {ECO:0000256|PIRNR:PIRNR009404,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|PIRNR:PIRNR009404,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 127..208
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT DOMAIN 215..359
FT /note="Transcription factor DP C-terminal"
FT /evidence="ECO:0000259|SMART:SM01138"
FT REGION 404..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 217..244
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 404..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..446
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 446 AA; 48984 MW; FD5BBA8035A8E3BA CRC64;
MTAKNIGVTS TNGDLKGFID QNWSPSKGNI SIIALPVSST NSPAKILPKT LGPINVNVGP
QMIISTPQRL TNSGSVLIGS PFTPAPAMVT QTHITEATGW VPGDRKRARE FIESDFSESK
RSKKGDKNGK GLRHFSMKVC EKVQRKGTTS YNEVADELVS EFTNSNSHLA TDSAYDQKNI
RRRVYDALNV LMAMNIISKE KKEIKWIGLP TNSAQECQNL EIEKQRRLER IKQKRAQLQE
LLLQQIAFKN LVQRNQQNEQ QNQSPPALNA TIQLPFLIVN TSKRTVIDCS ISSDKFEYLF
NFDNTFEIHD DIEVLKRMGM SFGLEAGKCS AEDLRTAKSL VPKALEGYVT DMSTGLSWLN
QGLLLNSAQP VSSSEVSGGT SISKSSGNLG LCLDAEVALA TGQFLAPGSQ QSSSATSRYS
ESRGETPCSF NDEDEDEDDD DSSSPE
//
