ID K7FJI8_PELSI Unreviewed; 1608 AA.
AC K7FJI8;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Calmodulin regulated spectrin associated protein 1 {ECO:0000313|Ensembl:ENSPSIP00000008198.1};
GN Name=CAMSAP1 {ECO:0000313|Ensembl:ENSPSIP00000008198.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000008198.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000008198.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- DOMAIN: The CKK domain binds microtubules. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
CC -!- SIMILARITY: Belongs to the CAMSAP1 family. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
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DR EMBL; AGCU01070038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01070039; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01070040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01070041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01070042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006120849.1; XM_006120787.2.
DR STRING; 13735.ENSPSIP00000008198; -.
DR Ensembl; ENSPSIT00000008241.1; ENSPSIP00000008198.1; ENSPSIG00000007403.1.
DR GeneID; 102444603; -.
DR CTD; 157922; -.
DR eggNOG; KOG3654; Eukaryota.
DR GeneTree; ENSGT00950000182975; -.
DR HOGENOM; CLU_004833_1_0_1; -.
DR OMA; EANHYII; -.
DR OrthoDB; 2918432at2759; -.
DR TreeFam; TF315529; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0036449; C:microtubule minus-end; IEA:Ensembl.
DR GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR GO; GO:0051011; F:microtubule minus-end binding; IEA:Ensembl.
DR GO; GO:0030507; F:spectrin binding; IEA:Ensembl.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
DR GO; GO:0022604; P:regulation of cell morphogenesis; IEA:Ensembl.
DR GO; GO:0031113; P:regulation of microtubule polymerization; IEA:Ensembl.
DR CDD; cd22265; UDM1_RNF168; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.10.20.360; CKK domain; 1.
DR InterPro; IPR032940; CAMSAP.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR031372; CAMSAP_CC1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR038209; CKK_dom_sf.
DR InterPro; IPR014797; CKK_domain.
DR InterPro; IPR011033; PRC_barrel-like_sf.
DR PANTHER; PTHR21595:SF3; CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR21595; UNCHARACTERIZED; 1.
DR Pfam; PF17095; CAMSAP_CC1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR Pfam; PF08683; CAMSAP_CKK; 1.
DR SMART; SM01051; CAMSAP_CKK; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50346; PRC-barrel domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51508; CKK; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|PROSITE-
KW ProRule:PRU00841}; Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 217..332
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1469..1603
FT /note="CKK"
FT /evidence="ECO:0000259|PROSITE:PS51508"
FT REGION 354..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 827..873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1061..1173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1207..1230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1248..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1301..1432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 878..908
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1027..1054
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 430..449
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..793
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1061..1079
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1113..1127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1151..1168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1207..1224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1301..1356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1388..1430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1608 AA; 180213 MW; AB246657842BA328 CRC64;
MVDVDVCAGG DSTRRKMDAL TDSAVEIVPL ELYDSARAKI AANLQWICAK AYGIDNIPEE
LKDPFYIDQY EQEHIKPPVI KLLLSSELYC RVCSLILKGD QVAALQGHQS VIQALSRKGI
YVMESDDTPV SESDLACAPI KMSSHMAMID SLMMAYTVEM ISIEKVVASV KRFSTFSASK
ELPYDLEDAM VFWINKVNLK MREITEKEVK LKQQLLESPG HQKVRYRRDH LSSRQLPYFP
LLEDLMKDGS DGAALLAVIH YYCPEQMKLD DICLKEVTSI ADSLYNIQLL REFSNEYLNK
CFYLTLEDML YAPLVLKPNV MVFIAELFWW FENVKPDFVQ PRDIQEIKDA KTVLQQKSSR
PPVPISNATK RSFMASPAST SPADLQPSIQ LPQEACNRYY LHPEESDYLG KGSPAFSPSH
PLLPLRQKQQ KSLQEEDCSS HRHRSNSLTR VDGQPRGSVL AWPEKKPRPL SQPTPFALHH
ATSSDVDPGS GDSISLARSI SKDSLASNIV TLTPKHPSHP SSMKTNGKTL LNNVEIEDED
EELIAIIRSD EIPDHDDLEL QSVSSRAPSL VAAAWSSKPQ SEAIESKADS FYLEPLMPAV
LKPAKEKQIT NKEDECGEGK QRGFITKRLN EGHLPMVRKK ANSSHADHDI NRTFTPISSS
DFTAVADPCT ADSVTLSEAG FEAPRPSASS SLEPSSQEQS TGGFFLHTAK VEDVTRKVSV
SYVKSTNSHI PSPTWTVVRQ DSDSDLDTDV AEQDLVVVDD RPVVSKYIGE EESAKLQEDM
KVKEHEDKDD ASGRSSPCLS TISQVSSVSM TSGSVRMTNF AERKLQRLNS YETKSSTSSS
QKTTPDGSES CPAPLTTWKQ KREQSPTRQN KDNVTLLASE LVQLHMQLEE KRRAIEAQKK
KMEALSARQR LKLGKAAFLH VVKKGKAVDV PQPLKPEHFA KEYSRNSGED LDDVSLSSKS
EEFLVKEEER EEMFYDSQEV SKMKMQENLA LVELHKPKEC AAMHEIEKSK IISAALLEDN
GAEVVDINEC DLSIEKLNET ISTLQQAILK ISHQQELLMK SPTVPSPSIR NNSQDQKVKP
SIHFVEPLSP TGMSSLRKPP RLGQGRGPRS GRPAELRVAK DRHQNSTRIK TPTQSVETLP
HLRPFPANNP CRTPTEASFE NSPDHGSGSQ DKFFFDSYRR HDESNQRAFV LSTSKDANII
SEMSKDMNSS LKEEGLNSSD GSGKENVPVD EPLKNKVNLI EVDLSDLKAP DEEGEIESQD
SSTDLINEGD QKSGVGFFFK DEHKAEDELA KKRAAFLLKQ QRKAEEARIR KQQLEAEVEQ
KRDEARRKAE EDRIRKEEEK ARRELIKQEY LRKKQQQILE EQGLGKPKSK PKKPRPKSVH
REESYSDSGT KCSSTPDNLS SAQSGSSLSL ASAATTEPES IHSGGTPSQR VESMEFLPIL
SRNPSRNTER DWENASTASS IASVAEYTGP KLFKEPSSKS NKPIIHNAIS HCCLAGKVNE
PHKNSILEEL EKCDANHYII LFRDAGCQFR ALYCYYPDTE EIYKLTGTGP KSINKKMIDK
LYKYSSDRKQ FNLIPAKTMS VSVDALTIHN YLWQAKRPAV PKKTQTRK
//
