ID K7FJW1_PELSI Unreviewed; 466 AA.
AC K7FJW1;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Clusterin {ECO:0000256|RuleBase:RU000629};
GN Name=CLUL1 {ECO:0000313|Ensembl:ENSPSIP00000008321.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000008321.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000008321.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the clusterin family.
CC {ECO:0000256|ARBA:ARBA00010069, ECO:0000256|RuleBase:RU000629}.
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DR EMBL; AGCU01201481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01201482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01201483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FJW1; -.
DR STRING; 13735.ENSPSIP00000008321; -.
DR Ensembl; ENSPSIT00000008364.1; ENSPSIP00000008321.1; ENSPSIG00000007587.1.
DR eggNOG; ENOG502QQ44; Eukaryota.
DR GeneTree; ENSGT00530000063668; -.
DR OMA; YLSEDCP; -.
DR TreeFam; TF333030; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR000753; Clusterin-like.
DR InterPro; IPR016015; Clusterin_C.
DR InterPro; IPR016014; Clusterin_N.
DR PANTHER; PTHR10970; CLUSTERIN; 1.
DR PANTHER; PTHR10970:SF2; CLUSTERIN-LIKE PROTEIN 1; 1.
DR Pfam; PF01093; Clusterin; 1.
DR SMART; SM00035; CLa; 1.
DR SMART; SM00030; CLb; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..466
FT /note="Clusterin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003905307"
FT DOMAIN 25..237
FT /note="Clusterin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00030"
FT DOMAIN 238..463
FT /note="Clusterin C-terminal"
FT /evidence="ECO:0000259|SMART:SM00035"
FT COILED 77..111
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 466 AA; 54231 MW; 1E41EDF66DD34DED CRC64;
NMKSCWLILI HLLWLRDHQC APTKEQEINP REQLKTLSEV GEKYVDEEVK KALIGIKQMK
VMMERNEDKH VHLMKTLKKS SEEKQEALRL MDEVKEQLEE EERQCQVALR NLWDECKTCL
ESNCMRFYTT CQHGLSTFTS KVEDFFRKIS PLTFTFHEDQ EKDFQSNEKP EKENAQLVQM
EDLFSQLLLD VSTIFDKSFA FFKQMQKEFD QSFQIYFVSD LDFTEPYYMP AFPEDPVGNS
GFQKDWGMPG FLQIFFDFSK TLFEGVSEVI SEAIDGYTES ERDLPEEAKD SDRSGMLSKI
IPGHKRMLCK ELRQNSSGCP QFQERCQKCQ DNLMKECPNV PELHIKFDEA FKLVNVSDEQ
YKQILQVVQR HTEDTSYLLS KMKESFGWVS ELSNVTIGPE NIFNIVKVSP SVQEADSFSL
NGTVVDVNIL TSPTFTIKVP HNLNIGSSEF IEYVAGKALQ LYKQNF
//
