ID K7FK06_PELSI Unreviewed; 778 AA.
AC K7FK06;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Nibrin {ECO:0000256|ARBA:ARBA00020013, ECO:0000256|PIRNR:PIRNR011869};
GN Name=NBN {ECO:0000313|Ensembl:ENSPSIP00000008366.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000008366.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000008366.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the MRE11-RAD50-NBN (MRN complex) which plays a
CC critical role in the cellular response to DNA damage and the
CC maintenance of chromosome integrity. The complex is involved in double-
CC strand break (DSB) repair, DNA recombination, maintenance of telomere
CC integrity, cell cycle checkpoint control and meiosis.
CC {ECO:0000256|PIRNR:PIRNR011869}.
CC -!- SUBUNIT: Component of the MRN complex. {ECO:0000256|PIRNR:PIRNR011869}.
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR011869}.
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DR EMBL; AGCU01115883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115885; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115887; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FK06; -.
DR STRING; 13735.ENSPSIP00000008366; -.
DR Ensembl; ENSPSIT00000008410.1; ENSPSIP00000008366.1; ENSPSIG00000007528.1.
DR eggNOG; ENOG502QQ7Y; Eukaryota.
DR GeneTree; ENSGT00390000000521; -.
DR HOGENOM; CLU_023410_0_0_1; -.
DR OMA; KKNFKMF; -.
DR TreeFam; TF101103; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0070533; C:BRCA1-C complex; IEA:Ensembl.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0030870; C:Mre11 complex; IEA:Ensembl.
DR GO; GO:0042405; C:nuclear inclusion body; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0016605; C:PML body; IEA:Ensembl.
DR GO; GO:0005657; C:replication fork; IEA:Ensembl.
DR GO; GO:0035861; C:site of double-strand break; IEA:Ensembl.
DR GO; GO:0003684; F:damaged DNA binding; IEA:Ensembl.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:Ensembl.
DR GO; GO:0006302; P:double-strand break repair; IEA:Ensembl.
DR GO; GO:0097193; P:intrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0045190; P:isotype switching; IEA:Ensembl.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; IEA:Ensembl.
DR GO; GO:1904354; P:negative regulation of telomere capping; IEA:Ensembl.
DR GO; GO:0007405; P:neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
DR GO; GO:0031954; P:positive regulation of protein autophosphorylation; IEA:Ensembl.
DR GO; GO:0032206; P:positive regulation of telomere maintenance; IEA:Ensembl.
DR GO; GO:0090656; P:t-circle formation; IEA:Ensembl.
DR GO; GO:0031860; P:telomeric 3' overhang formation; IEA:Ensembl.
DR CDD; cd17741; BRCT_nibrin; 1.
DR CDD; cd22667; FHA_NBN; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.40.50.10980; Nibrin, BRCT2 domain; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR040227; Nibrin-rel.
DR InterPro; IPR032429; Nibrin_BRCT2.
DR InterPro; IPR043014; Nibrin_BRCT2_sf.
DR InterPro; IPR013908; Nibrin_C.
DR InterPro; IPR016592; Nibrin_met.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR12162:SF0; NIBRIN; 1.
DR PANTHER; PTHR12162; NIBRIN-RELATED; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF08599; Nbs1_C; 1.
DR Pfam; PF16508; NIBRIN_BRCT_II; 1.
DR PIRSF; PIRSF011869; Nibrin_animal; 1.
DR SMART; SM00292; BRCT; 1.
DR SMART; SM00240; FHA; 1.
DR SMART; SM01348; Nbs1_C; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|PIRNR:PIRNR011869};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|PIRNR:PIRNR011869};
KW DNA repair {ECO:0000256|PIRNR:PIRNR011869};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254, ECO:0000256|PIRNR:PIRNR011869};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR011869};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Telomere {ECO:0000256|ARBA:ARBA00022895, ECO:0000256|PIRNR:PIRNR011869}.
FT DOMAIN 24..83
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 125..182
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 365..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 778 AA; 86651 MW; BC1BF97623D914CA CRC64;
FYKGSGGEGQ AGGEPYRLLV GTEYVVGRKN CSILIQDDQS ISRTHAVLTV THPEPNLSQA
LTVPELVIKD TSKYGTFVNG EKLLNGTSRT LKSGDRVNFG VFESKFRVEY DPLIVCSSCL
EASGKTALNQ AILQLGGIVV NDWSKECTHL VMISVKVTVK TICALICNRP IIKPEYFVEC
IQAIQSKQQL PKLESFYPPV DEPAIGTEKL DLSMRQERNT IFGGKTFLFL SAKQHKKLSP
AIILGGGEAK LLTERRKETS LLVAPEACVV DAGLTNSQVA VSDSVRNWID SIMTTLQSKN
LRTIPEAEIG LAVIFMSMER YCNPQNQPGT SLRSAIPHAT LSQSSTVDET IMPVATSDSK
AYVADTESEE LTDTCMETGG EDRDNTPKMD RRDKMYSQNI TTVKETPSTS GIVNSETALH
RVHRMSGIDL KSQPLSPSKI LGTNRIRERT SQRESNSITN YFQAAPKKRL RERIEEGETS
APKLAKMEEK SSHLCSQTQP TTSLMWKSKV EQTQKEQCTL DLKANLLPKD TGLKFAMESS
KSEKDKTVTK NVSSEKPASK KRKVLGDLVE DAATLELVFG SEELDWEAEM GDHDEVHGAN
MQKKRRLEAK ENTTFQDACS PSSSQIDCLV KQQENELGAV PTSKKQIEVK QESSVLVRNY
SKNTDQLQDD SSNLPSRLLL TEFRSLVVSH PRPNSLVAAQ TNYGQLNNFK KFKKVPYPGA
GQLPRIIGGS DLISHHAKKN SQLEEWLRQE MEEQNRHARE ESLADDLFRY DPNVKRRR
//
