ID K7FL29_PELSI Unreviewed; 1057 AA.
AC K7FL29;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000008739.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000008739.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|RuleBase:RU003431};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; AGCU01165978; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01165979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01165980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FL29; -.
DR Ensembl; ENSPSIT00000008785.1; ENSPSIP00000008739.1; ENSPSIG00000007899.1.
DR GeneTree; ENSGT00940000163069; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06372; PBP1_GC_G-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR001170; ANPR/GUC.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF500; GUANYLATE CYCLASE 2G; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00255; NATPEPTIDER.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 516..794
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 858..988
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 1057 AA; 118988 MW; 97A28E24A16DBB43 CRC64;
LETSQLTVAL QAPWNASHPL SAQKLGSAIQ IAIDKVNSDR SYLGNYTLDF VYADCGCNAK
KSVNAFISQV LKENVSALFG PVCSEAAEVT GLLASHWNIP WFGFAGQSAN LDNEVLYDTY
VKVVSPLQRI GEVLRESLQY FGWKYVGLFG GSSDTSTWEK IDGLWRSVEN QLKVNITITA
KVRYNTQDPS LHRENLKYIS SVARIIVLIC SFSDVTSIML EARHLGLVNG KFVFFVLQQF
EDNFLKGTLR NEKNSSVLEA YKSVFLIGLS PYGGYSMYSD FVKQVHEKLK GRPFYSSLSS
EQEVSAYSAY LHDAVLLYAR SIREMIKEGK EISDGRALVN TLRGYNKTDL YGVTGLVYID
EAGQRWMDYS VYDLQKAGNS SQFVPILNYD VVRRTISPTR EIAYIDWQAG FPPKDGPYCG
FHNEQCETSA LSEYGTPVTV LMVVLLVTAS GAASLVVFLK IQGKKLQKQR DDSWWKINHD
DIIMLNDHKL SHTGTPVSKG QESVGSSLIF SSSWRSGFKD KLGKDLFYAT IGLYQGALVA
LRYIENQTDA WIWKQSVLRE IQMMRELRHE NLVTFFGVCT DVPNICIITE YCKKGSLKDI
LRNSDIELDW IFKLSFAYDI VNGMLFLHRS PLNSHGNLKP TNCLVDSRMQ VKLCGFGLWE
FKYGKKYRVI TEKNTNYADL YWTAPELLRM GEFPFHGTQK GDVYSFAIIM RELIYNNEDG
PFQDLNKEAE EIINRLRDPT VLVPLRPSLS TEKCSERIIA MLRTCWDEDP GRRPTFSSVK
RGLRDASPEG HIGILDNMVN KLETYANHLE EVVEERTAQL VAEKKKTDKL LSAMLPSFIR
EQLIAGKSVE PESFESVTIF FSDIVGFTTL CSLSNPLQVV SLLNDLYSLF DNIIKTYDVY
KVETIGDAYM VASGLPIRNG MKHVEEIATM SLHFLNAVVP FKIGHMPKDK LKLRIGINTG
PVVAGVVGIT MPRYCLFGDT VNMASRMEST SLPLRIHVST TTANALQSIG GYDLQERGTI
TVKGKGEHRT FWLKGKDGLH LSLPELSDNE AKHSDSF
//
