ID K7FLU4_PELSI Unreviewed; 819 AA.
AC K7FLU4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=dynamin GTPase {ECO:0000256|ARBA:ARBA00011980};
DE EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
GN Name=DNM3 {ECO:0000313|Ensembl:ENSPSIP00000009004.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000009004.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000009004.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
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DR EMBL; AGCU01124977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01124978; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01124979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01124980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01124981; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01124982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01124983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01124984; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01124985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01124986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 13735.ENSPSIP00000009004; -.
DR Ensembl; ENSPSIT00000009050.1; ENSPSIP00000009004.1; ENSPSIG00000008010.1.
DR eggNOG; KOG0446; Eukaryota.
DR GeneTree; ENSGT00940000158056; -.
DR HOGENOM; CLU_008964_5_0_1; -.
DR OMA; EINRIFH; -.
DR TreeFam; TF300362; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd08771; DLP_1; 1.
DR CDD; cd01256; PH_dynamin; 1.
DR Gene3D; 1.20.120.1240; Dynamin, middle domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR019762; Dynamin_GTPase_CS.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF54; DYNAMIN-3; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF02212; GED; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00302; GED; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00410; G_DYNAMIN_1; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW GTP-binding {ECO:0000256|RuleBase:RU003932};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003932};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 1..249
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 469..575
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 609..700
FT /note="GED"
FT /evidence="ECO:0000259|PROSITE:PS51388"
FT REGION 580..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..769
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..808
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 819 AA; 92188 MW; 16A025529136917A CRC64;
FSCRDFLPRG SGIVTRRPLV LQLVTAKTEY AEFLHCKGRK FTDFDEVRQE IEAETDRVTG
LNKGISSIPI NLRVCSPHVL SLTLVDLPGI TKIPVGDQPP DIEQQIRDMI MQFISRENCL
ILAVTPANTD LANSDALKLA KEVDPQGGGA AGLRTIGVIT KLDLMDEGTD AREILENKLL
PLRRGYVGVV NRSQKDIDGK KDIKAAMLAE RKFFLSHPAY RHMADRMGTL YLQKVLNQQL
TNHIRDTLPA FRSKLQSQLL SLEHEVEAYR NYQPEDPTRK TKALLHTTCQ FCFCFALXIE
GSGDQVDTLE LSGGAKINRI FHERFPFELV KMEFNEKELR REISYAIKNI HGIRTGLFTP
DMAFEAIVKK QIVKLKGPCL KSVDLVMQEL INTVKKCTKK LATYPRLCEE TERIVTGHIR
DREEKTKEQV LLLIDIQVSY INTNHEDFIG FANAQQRSSQ VSKSTVGNQV IRKGWLTINN
IGIMKGGSKE YWFVLTAESL SWYKDDEEKE KKYMLPLDNL KVRDVEKSFM SSKHIFALFN
TEQRNVYKDY RFLELACDAQ EEVDSWKASL LRAGVYPDKS SISGSQPTEN DETSQADNFS
MDPQLERQVE TIRNLVDSYM SIINKCIRDL IPKTIMHLMI NNVKEFINAE LLAHLYSSED
QNTLMEESAE QAQRRDEGLR MYQALKEALA IIGDINTSTV SIPAPPPVDD SWLQQSRRSP
PPSPSIQKRP TLNNPPTRPI AGRGPAPATP SPGPLSGAPP VPFRPGMLPP FPSNSEGLGA
PPQVPSRPTR APPSVPSRRP PPSPTRPTVI RPLDSSLLD
//
