ID K7FLV2_PELSI Unreviewed; 204 AA.
AC K7FLV2;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Transmembrane protein 182 {ECO:0000256|ARBA:ARBA00014600};
GN Name=TMEM182 {ECO:0000313|Ensembl:ENSPSIP00000009012.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000009012.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000009012.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM182 family.
CC {ECO:0000256|ARBA:ARBA00006418}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGCU01116641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01116642; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006127716.1; XM_006127654.2.
DR AlphaFoldDB; K7FLV2; -.
DR STRING; 13735.ENSPSIP00000009012; -.
DR Ensembl; ENSPSIT00000009058.1; ENSPSIP00000009012.1; ENSPSIG00000008229.1.
DR GeneID; 102448738; -.
DR KEGG; pss:102448738; -.
DR eggNOG; ENOG502QVS4; Eukaryota.
DR GeneTree; ENSGT00390000017581; -.
DR HOGENOM; CLU_105472_0_0_1; -.
DR OMA; VTEVGKC; -.
DR OrthoDB; 5209594at2759; -.
DR TreeFam; TF331344; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR GO; GO:0014906; P:myotube cell development involved in skeletal muscle regeneration; IEA:Ensembl.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR GO; GO:1901740; P:negative regulation of myoblast fusion; IEA:Ensembl.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR026763; TMEM182.
DR PANTHER; PTHR32012:SF0; TRANSMEMBRANE PROTEIN 182; 1.
DR PANTHER; PTHR32012; TRANSMEMBRANE PROTEIN 182-RELATED; 1.
DR Pfam; PF13903; Claudin_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Myogenesis {ECO:0000256|ARBA:ARBA00022541};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 204 AA; 23073 MW; 7FF9CAF38B0B6559 CRC64;
MKLSVGIFFG GFFGALGVLL FLVAFGTDYW LLATEVERCS GGPNNTREEQ VTFHHEGFFW
RCWFVGDVGE DTNSIWKFWY TNQLPSKNCT HAYLSPFPFI RDEHNSTSYD SAIIYRGVWS
VLMLLGVITV LVGSFFIICA APFASHILYK AGGGIFIAAG ILFSLVVVMY VIWVQAMADL
ENYMNTKKMD CPDFVVYVRY GCIH
//
