ID K7FLY4_PELSI Unreviewed; 4487 AA.
AC K7FLY4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Dynein axonemal heavy chain 5 {ECO:0008006|Google:ProtNLM};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000009044.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000009044.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; AGCU01019230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01019231; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01019232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01019233; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01019234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01019235; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01019236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01019237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01019238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01019239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 13735.ENSPSIP00000009044; -.
DR Ensembl; ENSPSIT00000009090.1; ENSPSIP00000009044.1; ENSPSIG00000008001.1.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000164265; -.
DR OMA; PFIGQVE; -.
DR TreeFam; TF316836; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF13; DYNEIN CYTOPLASMIC 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 131..681
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 1259..1664
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1799..2126
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2283..2397
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2627..2707
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2778..3040
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 3053..3399
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3427..3647
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3893..4002
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 4033..4172
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 4178..4484
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 3062..3089
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3282..3330
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3588..3615
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4487 AA; 514022 MW; A661217DB2F88319 CRC64;
VLQALTGTCA FFLRTTDKAV TTTNISQEVN FGMFDCTNGS ILQGLEFFLA QVMVPALKSQ
QHWGAVKDGL KNSQIQDFLF SVDKFVGTLS SARQILEDKI QLQKVDIESY LNNLHNPSDY
ITAGNNIDLI EKAEGVLMIW IKQIGQILVE SEQMRKEADD IGPSAELEHW KSRMASFNSL
LDEIKSPRVK KVLSILQAAK SRLLKQWKEL DGNVTNAANE AKDNVKYLYT LDKFFGPLGK
ASPVTMVEHI PSLMSSIRMI YSTSPYYNTS EQMTSLLLKI TNQMINTCKI FLSEGVLKIW
DLDRQELLKR VQECIYLNEQ YQTYFQRVRE KLKENPSDRQ FDFSENYIFG KFDAFCKRLE
KISDMSNIME GLLELQNIKI EGIEKINAHY ETIATNTKSK TYDVLDHRKQ EFEKDYLEFK
NQIEGLYQSV KELVDSWFEK SLTTEQMLAL LIKFEHTGKG NIDLTEKYII VLQRYNRDLD
MVRKLYQKQK ENPPIPRNVP PVTGKIMWAR QLFRKIDYPM KFFKKKTALW KTPEMKKVIW
SYNKMAAVLL EFELLYHRAW CRFAEQAKNG LRASLLVRHP ETKELFVNLD PMVLEVLCET
KYLKKMDFEV PDVALGMWAE EEQIKNQQMK LQDLLIDYKK FVNGIPTILE PLMKPFMEQI
EETLTPGLTH LSWTSSSIDK FLEKVYNSLE DVGHIVKEAS DTLECRIERI LRDMSDISLV
TLPEDEPIEV PAFLERTEKL TAAAAETLSQ VYSCVVYVLK SIMFHGRQSQ QVERSMYELI
DILKHRLKPE DKSNLQVRPK LDSFACGHLD TKQKTRCQEC LSCSYYNLMG QLCQKNTDSL
VKCTKMSLDA LRCRVHVLNS KYQMTRFIKD ERVPLFKAEI QLAIPNIVLR PSLDDIQNAV
NKAVNIILST ARDIPQWKFA HLHHRQQQVK YIFRQQQSQM EQAAAIELGD ESKLSKMVTL
RSLDKQISEH KDVNKVMIQL TTVISSLKTD AADILKSFAK FSSIWIQDPE EKVKEFLETN
PVMSEFQTQM NYFSQLEIQI RELPSHCILE SVDFATESLK MALIQECRLR QRTFGLALNK
KAAMDMDEIY TFIDNLSKRL NRPINDLDDV RGAMEALKEI REAEIKIDMT VGPIEESYAL
LHKYDLLFKD GNAERVDGLA YAWKNLNTQV LKMQDLLLKV QPSMKTDLLN GIKKFQTDAV
EFYKDYNETG PGVEDIAPWE ASDRLQIFQA KFDELWRKYI TFSGGEELFG LSVTEYPELQ
KIKRELTLLQ RLYGLYNSVN ASISGYYEIL WSDLDIEKIN SELVDFQNRI RKLPKALKEW
QAFHDLKKKI DDFAESGPLL EMMANKAMMP RHWERIAQVT GHNFDVVSES FSLKNIMDAS
LLKYKEDIED ICISAVKEKD IEAKLKHVIS EWTTHVFTFG QFKTRGELLL KGSDTSEKIA
LMEDSLMILG SLMSNRYNAP FKPIIQQWVQ KLANTTEIIE SWITVQNLWI YLEAVFVGGD
IAKQLPQEAK RFQNIDKSWQ KIMQRAHETS NIVQCCVGDE TLAQLLPHLL EQLEICQKSL
TGYLEKKRLV FPRFFFVSDP ALLEILGQAS DSHTIQAHLL SLFDNVNRVG FHEKNYDQIL
LFESQEGEQV NITEPVLAQG NVEFWLGQLL NGIKKTIHSI IRQASIAISD SGFKLYDFQA
TFPAQIGLLG IQMIWTRDAE DALNNAKTDK KVMHSANQKF LDLLNELIDM TTRHLTSMER
TKYETLITIH VHQKDIFDDL VRMNIKSPSD FEWQKQSRFY FIEDADKCII QITDVEFSYC
NEYLGCTDRL VITPLTDRCY ITLAQALGMS MGGAPAGPAG TGKTETTKDM GKCLGKYVVV
FNCSDQMDYR GLGRIYKGLA QSGAWGCFDE FNRIELPVLS VAAQQIYIVL QCKKNKKPQF
IFTDGDVVHM DREFGIFLTM NPGYAGRQEL PENLKIQFRT VAMMVPDRGI IMRVKLASAG
FRDNQILSRK FYTLYKLCEE QLSKQVHYDF GLRNILSVLR TLGSVKRSNP NEPERTVVMR
VLRDMNLSKL VDEDEPLFMS LINDLFPGIT LDKVGYPELE SAIQKQTEKA GLIHHPPWIL
KLIQLYETQQ VRHGMMALGP TGAGKTKCIN ILMKSMTDCG TPHKEMRMNP KAITASQMFG
TLDVATNDWT DGIFSTLWRK TLKAKKGEHV WIVLDGPVDA IWIENLNSVL DDNKTLTLAN
GDRIPMSPNC KIVFEPHNID NASPATVSRN GMVFMSSSVL DWRPVLKAWL QTLPATHADV
LWNSFNGVFQ DLIDFVFTAV TPKMPVLECM YIKQAIDLLE GLLADRNEKQ PSQEHIARLF
VFAIMWSVGA LLELDDRVKM ELFLQNHSAK LELPAVNGEE TMFEFGVSDY GQWEHWSKRV
PEYVYPKDSV PEYNSILVPN VDNVRTDFLM DAIMKQGKAV LLTGEQGTAK TVMVKGYTSK
YDPDFHLTKR LNFSSATLPN MFQRSIESYI DKRMGTTYGP PAGKKMTIFI DDINMPVINE
WGDQITNEIV RQLMEQNGFY NLEKPGEFTN VVDIQFVAAM IHPGGGRNDI PQRLKRQFTV
YNCTLPSNSS IDKIFRTLAE GYFCVQRGFP EEICKLASAL VPTTRKIWQA TKVKMLPTPA
KFHYIFNLRD LSRIWQGILT ISADVCRNTS VLAALFHHEC SRVIADRFIN QNDTDWFEDM
MKKITSEDHD QDLLGNDCKE LYFVDFLRDA PEATGDEPDD IELEAPKIYE SISSFDILAE
RLQMFMQLYN ETIRGTHMDL VFFKDAMIHL VKISRIIRTP KGNALLVGVG GSGKQSLTRL
ASYIAGYQSF QITLTRTYGI NNLMDDLKIL YRTAGQKGQG ITFIFTDNEI RDESFLEYMN
NVLASGEVSN LFARDEIDEI TQDLISVMKK EYPRRSPSSE NLYDYFLTRV RNNLHVVLCF
SPVGEKFRTR ALKFPGLISG CTMDWFQRWP KDALVAVAQH FLASYKIECT DEVKQSVVNT
MGTFQDLVAV KCIQYFERYR RQTFVTPKSY LSFIGGYKTI YREKFAGVGN LSDRMKTGLA
KLMEAEFSVN QLSKELAVKE RDLAVASKKA DGVLLEVTLK AQAAETVKMQ VQKVKDKAQA
IVDEIAIDKA AAEQKLEAAR PALEEAEAAL QTIKPADIAT VRKLGKPPHL IMRIMDCVLL
LFQRKIDSVT ADPERTCVKP SWTEALKLMN NSGFLSMLLS FQKDSITEEI VELLQPYLDM
EDYNLETAKK VCGNVAGLCS WTQAMAYFYS INKEVLPLKA NLALQEARLA VAQDELNNAQ
NQLDEKQREL DQVQAMYNAA MQEKQTLLDD AETCRRKMNN ATALIEGLGG EKIRWTESSK
NFQKQIIQLV GNVLLATGFL SYSGPFNQEY RNLLLRLWKK EMDRNRIPYS DDLNLISMLV
DNATVGDWNL QGLPNDDLSI QNGIIVTKAS RYPLLIDPQG QGKIWIKNKE KNNELQVTSL
NHKYFRSHLE DCLSLGRPLL IEDVGEELDP ALDNILEKNF IKSGSTHKVK VGDKEVDVMK
GFTLYLTTKL ANPAYTPEIS AKTAVIDFTV TMKGLEDQLL GRVILTEKQE LEAERVKLME
EVTSYKRKMQ DLEDSLLFRL TSTEGSLVED ESLIEVLRIT KTTAEEVSEK LNTAAETEVK
INTAREEYRP VACRGSILYF LIVEMSLVNV MYQTSLRQFL GIFDLSVERS VKSQITAKRV
ANVIEHLTYE VYKYTVRGLY ENHKFLFTLL MALKIDLQAK KISHNEFQTF IKGGASLDLN
SVQPKPKKWI LDMTWLNLVQ LSNLYPFNQL LGQVTRSEKA WKAWFDEETP EEAPLPDGYD
SLLDTFRKLL LIRSWCPDHT IAQARHYIAE SLSMKYAEGF ILDMEAMWSE SDCRTPLTCF
LSMGSDPTEN IERLAKSKNI SCCAISMGQG QETHARRLLN QCMQDGGWLL LQNCHLGLDF
LDELLDTIVT TESMNEGFRT WITTEVHSKF PINLLQSSIK FTNEPPQGVK AGLKRTYSAI
SQEQLEVSNM PQWKPLLYAV AFLHTTVQER RKFGPLGWNI PYEFNQADFA ASVQFIQNHL
DEVDLKRGVN WSCVRYMLGE VQYGGRVTDD LDKMLLNTFA RVWFGESMFT DKFCFYKSYI
IPKGKTVEDY LQHIDQLPMV DTPEVFGLHP NADITYQTNM ANETLSTIVS IQPKDSGSGG
GETREAMVQQ LADEMLEKLP PDYIPHEVKA QFLKMGAIQP LNIFLRQEID RMQHVISRVR
TTLTDLKLAI DGTIIMSEDL RDALDNMYDA RIPKLWFKIS WESATLGFWF TELLERNQQF
SSWLLDGRPN QFWLTGFFNP QGFLTAMRQE TTRLNLAKGW ALDSVILHND VTRMMKEDIT
SPPPADIGGV YIYGLFLDGA GWDRRNMKLT ESAPKVLFTS LPVVHVYAIS TTAPPDSKKQ
PGGLYSCPVY KKPRRTDLTY IFSLYLKTVQ NPDHWTLRGV ALLCDSK
//
