ID K7FM21_PELSI Unreviewed; 1052 AA.
AC K7FM21;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=FERM, ARH/RhoGEF and pleckstrin domain protein 2 {ECO:0000313|Ensembl:ENSPSIP00000009081.1};
GN Name=FARP2 {ECO:0000313|Ensembl:ENSPSIP00000009081.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000009081.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000009081.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01003104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01003105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01003106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01003107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01003108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01003109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01003110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01003111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01003112; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01003113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006110686.1; XM_006110624.2.
DR AlphaFoldDB; K7FM21; -.
DR STRING; 13735.ENSPSIP00000009081; -.
DR Ensembl; ENSPSIT00000009127.1; ENSPSIP00000009081.1; ENSPSIG00000008274.1.
DR GeneID; 102463763; -.
DR CTD; 9855; -.
DR eggNOG; KOG3531; Eukaryota.
DR GeneTree; ENSGT00940000158642; -.
DR HOGENOM; CLU_012301_0_0_1; -.
DR OMA; HKHMPED; -.
DR OrthoDB; 2876516at2759; -.
DR TreeFam; TF351276; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:Ensembl.
DR GO; GO:0016322; P:neuron remodeling; IEA:Ensembl.
DR GO; GO:0030316; P:osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0071800; P:podosome assembly; IEA:Ensembl.
DR GO; GO:0016601; P:Rac protein signal transduction; IEA:Ensembl.
DR GO; GO:0033623; P:regulation of integrin activation; IEA:Ensembl.
DR GO; GO:0071526; P:semaphorin-plexin signaling pathway; IEA:Ensembl.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd17190; FERM_F1_FARP2; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 51..331
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 542..733
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 762..859
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 936..1033
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 429..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 882..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1033..1052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 644..674
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 894..910
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1052 AA; 121379 MW; 271549D39D721D44 CRC64;
MGEIEGTYRV LQTPGSRLGV QKNTGVSTLE PDQNLSTSIA MTPAKMHERD LSIKLKLLDN
TVEVLNVESK SYGQTLLTEI YKHLNLVESD YFGIEFQNIQ SYWIWLEPMK PIIKQVRRPK
NTMLRLAVKF FPPDPGQLQE EYTRYLFALQ IKRDLAEERL TCSDNTAALI ISHLLQSEIG
DFDESGDRSH LKTNQYLPNQ ERVQGKILEF HRKHLGQTPA ESDFQVLEIA RKLEMYGIRF
HLASDREGSK INLAVSHMGV LVFQGTTKIN TFNWSKVRKL SFKRKRFLIK LHPEVHGPYQ
DTLEFLLGSR DECKNFWKIC VEYHTFFRLF DQPKPKAKTV FFSRGSSFRY SGRTQKQLVN
YVKDSGMKKT PYERRHSKAR VSAHTSNVDV PKQSVSFTEG LGVPVSHASV SASFHSVYVS
STTDLSVCSE MNNSSRDPRA LYTRSPTTEK STATPAEETG KKATQQPGSP ILQSFQGLSM
IHPQLSSFTL KNPQSLNPTF QVNLNPADQG SSPLLSPVLS DAGSSRVEEE EEVKRKRYPA
DKAYFVAKEI LATERTYVKD LEVITVWFRS AVIKENAMPE GLMTLLFSNI DPIYEFHRSF
LKEMEQRLAL WEGRSNAHVK GDYQRIGDIM LRNMCMLKEF TGYLQKHDEV LTELEKATKR
LKKLEMVYRE FELQKVCYLP LNTFLLKPIQ RLMHYKLILG RLCKHYPVEH RDYSDCRKAL
KEITELTSWL ENSLIRLENF QKLTELQHDL IGIDNLVAPG REFIREGCLY KLTKKGLQQR
MFFLFSDMLL YTSKGVTGTN QFKIHGHLPL HGMLVEESEN EWSVPHCFTI YSAQKTIVVA
ACTRLEMGKW MEDLNVAIEM AKKSSNKSKV FLESSMYNRS NRSSDEVSLE QESEDDIQSS
RSSLDRQSHH RANTTMHVCW YRNTSVSMTD HSVAVENQLS GYLLRKFKNS DGWQKLWVVF
TNFCLFFYKT HQDDYPLASL PLLGYSVSAP TEADGVQKDY VFKLQFKSHV YFFRAESKYT
FERWMEVIQR ATNSPGRSSP AIPMEEKDIH TD
//
