ID K7FM91_PELSI Unreviewed; 1942 AA.
AC K7FM91;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Myosin-1B {ECO:0000313|Ensembl:ENSPSIP00000009151.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000009151.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000009151.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Muscle contraction. {ECO:0000256|ARBA:ARBA00037488}.
CC -!- SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy
CC chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2
CC regulatory light chain subunits (MLC-2).
CC {ECO:0000256|ARBA:ARBA00038612}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; AGCU01135997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01135998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01135999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01136000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01136001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01136002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01136003; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01136004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01136005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 13735.ENSPSIP00000009151; -.
DR Ensembl; ENSPSIT00000009197.1; ENSPSIP00000009151.1; ENSPSIG00000007567.1.
DR eggNOG; KOG0161; Eukaryota.
DR GeneTree; ENSGT00940000161336; -.
DR HOGENOM; CLU_000192_8_1_1; -.
DR TreeFam; TF314375; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF78; MYOSIN-4; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 34..83
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 87..783
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 660..682
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 847..895
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 982..1930
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 183..190
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1942 AA; 223480 MW; 692596B5E40A7433 CRC64;
AMSSDAEMAV FGVAAPFLRK SEKERIESQN KPFDAKTSVF VAHPKESYVK GILQSREGGK
ATVKTEKGET LTVKEDQIFS MNPPKYDKIE DMAMMTHLHE PGVLYNLKER YAAWMIYTYS
GLFCATVNPY KWLPVYNPEV VSAYRGKKRQ EAPPHIFSIS DNAYQFMLTD RENQSILITM
DSGESGAGKT VNTKRVIQYF ATIAVSGEKK KEEPGKMHGT LEDQIISANP LLEAFGNAKT
VRNDNSSRFG KFIRIHFGTT GKLASADIET YLLEKSRVTF QLKAERSYHI FYQIMSNKKP
ELIEMLLITT NPYDFPFVSQ GEITVASIDD QEELMATDSA IDILGFTAEE KTAIYKLTGA
VMHYGNMKFK QKQREEQAEP DGTEVADKAA YLMGLNSADL LKALCYPRVK VGNEYVTKGQ
TVQQVHNSVG ALAKAVYEKM FLWMVVRINQ QLDTKQPRQY FIGVLDIAGF EIFDYNSLEQ
LCINFTNEKL QQFFNHHMFV LEQEEYKKEG IEWEFIDFGM DLAACIELIE KPMGIFSILE
EECMFPKATD VSFKNKLYDQ HLGKSNNFQK PKPGKGKAEA HFALVHYAGT VDYNITGWLE
KNKDPLNETV IGLYQKSSLK TLALLFAALA GDAESGGGKK GGKKKGSSFQ TVSALFRENL
NKLMSNLRST HPHFVRCLIP NETKTPGAME HELVLHQLRC NGVLEGIRIC RKGFPSRIVY
ADFKQRYRVL NASAIPEGQF MDSKKASEKL LGSIDIDQTQ YKFGHTKVFF KAGLLGLLEE
MRDDKLAQLI TRTQAMCRGF LMRVEFKRMM ERRESIFCIQ YNVRSFMNVK HWPWMKLYFK
IKPLLKSAES EKEMANMKEE FEKTKEELAK SEAKRKELEE KMVSLLQEKN DLQLQVQSVS
IANQFNPYCT LEQSKLKVPI FILSKCQRKL DPERISAILS LVENRKISGN KGYCFHPEKS
ISNLDMTILS AYSIYLCSIQ KVKNLTEEMA VLDETIAKLT KEKKALQEAH QQTLDDLQAE
EDKVNTLTKA KTKLEQQVDD LEGSLEQEKK LRMDLERAKR KLEGDLKLAQ ESTMDLENDK
QQLEEKLKKK DFEISQFQSK IEDEQVLGIQ LQKKIKELQA RIEELEEEIE AERASRAKAE
KQRSDLSREL EEISERLEEA GGATAAQIEM NKKREAEFQK MRRDLEEATL QHEATAATFR
KKHADSTAEL GEQIDNLQRV KQKLEKEKSE LKMEIDDLAS NMETVSKTKA NLEKMCRSLE
DQLSEVKTKE EEHQRMINDL STQRARLQTE SGEFARQVEE KDTLVSQLSR GKQAFTQQVE
ELKRQLEEEI KAKNALAHAL QSARHDCDLL REQYEEEQEA KGELQRTLSK ANSEVAQWRT
KYETDAIQRT EELEEAKKKL AQRLQDAEEH VEAVNSKCAS LEKTKQRLQN EVEDLMIDVE
RSNAACAALD KKQKNFDKVL SEWKQKYEET QAELEASQKE SRALSTELFK MKNAYEETLD
HLETLKRENK NLQQEISDLT EQIAEGGKAL HELEKVKKQI EQEKSEIQSA LEEAEASLEH
EEGKILRIQL ELNQVKSEVD RKIAEKDEEI EQLKRNHIRV VESMQSTLDA EIRSRNEAMR
LKKKMEGDLN EMEIQLSHAN RLAADAQKNL RNTQGVLKDT QLHLDDALRS QEDLKEQVAM
VERRANLMQA EIEELRAALE QTERARKVAE QELLDASERV QLLHTQNTSL INTKKKLETD
ISQLQSEMEE TIQEARNAEE KAKKAITDAA MMAEELKKEQ DTSAHLERMK KNLDQTVKDL
QHRLDEAEQL ALKGGKKQIQ KLEARVRELE GEVDNEQKRS ADAIKGVRKY ERRVKELTYQ
SEEDRKNILR LQDLVDKLQL KVKAYKRQAE ESEELSNVNL TKFRKIQHEL EEAEERADIA
ESQVNKLRVK SREIHKKTEV EE
//
