ID K7FND3_PELSI Unreviewed; 800 AA.
AC K7FND3;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Fibrinogen alpha chain {ECO:0000256|ARBA:ARBA00017850};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000009543.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000009543.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-
CC identical chains (alpha, beta and gamma). The 2 heterotrimers are in
CC head to head conformation with the N-termini in a small central domain.
CC {ECO:0000256|ARBA:ARBA00025974}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; AGCU01009363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006111615.1; XM_006111553.2.
DR AlphaFoldDB; K7FND3; -.
DR STRING; 13735.ENSPSIP00000009543; -.
DR Ensembl; ENSPSIT00000009590.1; ENSPSIP00000009543.1; ENSPSIG00000008691.1.
DR GeneID; 102456080; -.
DR KEGG; pss:102456080; -.
DR CTD; 2243; -.
DR eggNOG; KOG2579; Eukaryota.
DR GeneTree; ENSGT00940000157467; -.
DR HOGENOM; CLU_013807_1_0_1; -.
DR OMA; PRIVEHM; -.
DR OrthoDB; 3134470at2759; -.
DR TreeFam; TF351984; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR GO; GO:0005577; C:fibrinogen complex; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:Ensembl.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0030168; P:platelet activation; IEA:InterPro.
DR GO; GO:0051258; P:protein polymerization; IEA:InterPro.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 1.20.5.50; -; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR Gene3D; 4.10.530.10; Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2; 1.
DR InterPro; IPR037579; Fibrinogen.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR012290; Fibrinogen_a/b/g_coil_dom.
DR InterPro; IPR021996; Fibrinogen_aC.
DR InterPro; IPR020837; Fibrinogen_CS.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR47221; FIBRINOGEN ALPHA CHAIN; 1.
DR PANTHER; PTHR47221:SF3; FIBRINOGEN ALPHA CHAIN; 1.
DR Pfam; PF08702; Fib_alpha; 1.
DR Pfam; PF12160; Fibrinogen_aC; 1.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR SMART; SM00186; FBG; 1.
DR SMART; SM01212; Fib_alpha; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF58010; Fibrinogen coiled-coil and central regions; 1.
DR PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 557..798
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT REGION 300..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 800 AA; 88558 MW; A2535BAEBC0BD322 CRC64;
MKQKKQVERI LSVRLLLTLP LKMIPLRILC MWLCLSIAWA TNDESTFLKE GGGVRGPRVM
EHASQSECKQ DKGWPFCADD DWGHKCPSGC RMQGLIDETD KDFHHRIQRI RNLLLDNENK
YKKSNVLTVE TINFLKGNLA SALESDNKYG QISEDLRRRL VLLKQKVLVQ VNRIKVLQNS
IRDQVVEMKR LEVDIDIKIR ACKGSCAKSL NYQVDTESYE NIQKQLTQAS SIDLQSVLET
SSLKVLKMRP LKDSIVPAHF KTLPQTQELN ILDEIVQVVM TLERPEGEEK VETSRVSVVS
GVGGGAQDGK TVTSSHGKET VGLGGKHTSI IRHTCTRTIT KKIITGPGGP REEIVETMTS
PDGSDCSHFQ GSGREEVTGR GDITHVRVTS QGGTSDLSKL IPEYEKFFTE SGSSSSKFHT
TYTSDSGTDH GTRTGSFGSG TGRYSSGGTA SHTTHSGGTE SFADLGEGEE DIFDPHFDPS
RLPSSKVQSG SSAHVETRVT SSSSSSTSFN KGGSTFETKS LKSRAVTEEL GGLQHEESGE
DTPDFRARSL RTAGEKLGTS YTGTDCDDIR QKHTSGAKSG IFRIKPAGSD KVFSVYCDQE
TTLGGWLLIQ QRLDGSVNFN RTWQDYKKGF GSMDGKGKGE FWLGNENIHL LTQKDTVLRV
ELEDWDGNEA YAEYNIHVGS ESDGYVLSVS AYEGTAGDAL IIGSVEEGIE YTAHANMKFS
TFDRDSDQWE ENCAEVYGGG WWYNNCQAAN LNGIYYQGGQ YDPRNNVPYE IENGVVWIPF
RASDYSLKVV RMKIRPIETQ
//
