ID K7FQG3_PELSI Unreviewed; 803 AA.
AC K7FQG3;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Mitotic arrest deficient 1 like 1 {ECO:0000313|Ensembl:ENSPSIP00000010273.1};
GN Name=MAD1L1 {ECO:0000313|Ensembl:ENSPSIP00000010273.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000010273.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000010273.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAD1 family.
CC {ECO:0000256|ARBA:ARBA00008029}.
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DR EMBL; AGCU01017951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017954; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01017960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FQG3; -.
DR STRING; 13735.ENSPSIP00000010273; -.
DR Ensembl; ENSPSIT00000010325.1; ENSPSIP00000010273.1; ENSPSIG00000009326.1.
DR eggNOG; KOG4589; Eukaryota.
DR eggNOG; KOG4593; Eukaryota.
DR GeneTree; ENSGT00390000001316; -.
DR HOGENOM; CLU_023576_0_0_1; -.
DR OMA; YKLDFMP; -.
DR TreeFam; TF101083; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0000776; C:kinetochore; IEA:Ensembl.
DR GO; GO:1990706; C:MAD1 complex; IEA:Ensembl.
DR GO; GO:1990728; C:mitotic spindle assembly checkpoint MAD1-MAD2 complex; IEA:Ensembl.
DR GO; GO:0097431; C:mitotic spindle pole; IEA:Ensembl.
DR GO; GO:0044615; C:nuclear pore nuclear basket; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0043515; F:kinetochore binding; IEA:Ensembl.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:InterPro.
DR GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:Ensembl.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
DR GO; GO:0090267; P:positive regulation of mitotic cell cycle spindle assembly checkpoint; IEA:Ensembl.
DR GO; GO:0090235; P:regulation of metaphase plate congression; IEA:Ensembl.
DR GO; GO:0048538; P:thymus development; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 3.30.457.60; -; 1.
DR Gene3D; 6.10.250.90; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR008672; Mad1.
DR InterPro; IPR002877; RNA_MeTrfase_FtsJ_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR23168:SF0; MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1; 1.
DR PANTHER; PTHR23168; MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1; 1.
DR Pfam; PF01728; FtsJ; 1.
DR Pfam; PF05557; MAD; 1.
DR SUPFAM; SSF75704; Mitotic arrest deficient-like 1, Mad1; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 1..83
FT /note="Ribosomal RNA methyltransferase FtsJ"
FT /evidence="ECO:0000259|Pfam:PF01728"
FT COILED 150..331
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 355..406
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 445..472
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 521..660
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 686..713
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 803 AA; 93338 MW; 2BB7C501708127C8 CRC64;
MAPNASGVRE LDHQKLINLC LSLLDLSKII LRPSGTILCK FWDGRETHLL QNRLKENFQD
VRTIKPQSSR KESAEIYYLA KRRELTMENS EDNTTVFSAL RSLNNFISQR VEGASSLAAP
GSLPSTLHMQ YQQRVQLEEQ AEQIHSKSQL LQVEREKMQM ELSHKRARIE LEKAANTNAR
SYEREADRNQ ELLTRIKHYQ EKEVEAEAKL KEQMEINTSY KKSMETVSKN LQEKESKLTE
ANETISILKG KISDLQWRLM NQEMQMTSHE SQKQELMEQL DMQHNKCQEA NQQIQLLQAS
QSLLAEHEQK IKDLEQKLSL QEQDASIVKN MKAELARFPK MERELLQLRE DNAYLREMKE
NNGLLREEVE GLQRKLERFE KVQADLVTLE LENEKLLGKL KSWEKLDQST GLSIRTPDDL
SRQIVALQQR ELVLKEQNCT ITNSARILEK ARQQLQEDIL RIQSQLLDEK KKREHHEAFV
RRLQKRVLLL TKERDGMRAI LESYDNELTP SEHSPQLSRR MREAEEMVQK MHAHNAELEA
QLSQVLEEVG TQKQRADMLE VELKSLKSQE CTAAHSTFIT TEEVKALRLK IEELEAERGH
LEEENKSLEM KLEKLTLQGD YDRSKTKVLH FSMNPASLAK QQRKDEQHQL QEECEKLREM
VRVLEGGGSI PENLEIVGSL QSPQEVAELK KQVESAELKN QRLKEVFQTK IQEFRKVCYT
LTGYQIDITT ENQYRLTSMY AEHQGDCLLF KASSSSGGKM QLLETEFSLT IRELIDLHLL
HQDSIPAFLS AVTLELFSRQ TCA
//
