ID K7FR08_PELSI Unreviewed; 322 AA.
AC K7FR08;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=GDNF family receptor alpha 3 {ECO:0000313|Ensembl:ENSPSIP00000010468.1};
GN Name=GFRA3 {ECO:0000313|Ensembl:ENSPSIP00000010468.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000010468.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000010468.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GDNFR family.
CC {ECO:0000256|ARBA:ARBA00005961}.
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DR EMBL; AGCU01075754; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FR08; -.
DR STRING; 13735.ENSPSIP00000010468; -.
DR Ensembl; ENSPSIT00000010521.1; ENSPSIP00000010468.1; ENSPSIG00000009476.1.
DR eggNOG; ENOG502QWSW; Eukaryota.
DR GeneTree; ENSGT00940000161256; -.
DR HOGENOM; CLU_040179_1_0_1; -.
DR OMA; NSISWMG; -.
DR TreeFam; TF331647; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0008046; F:axon guidance receptor activity; IEA:Ensembl.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:0048485; P:sympathetic nervous system development; IEA:Ensembl.
DR Gene3D; 1.10.220.110; GDNF binding domain; 1.
DR InterPro; IPR016017; GDNF/GAS1.
DR InterPro; IPR037193; GDNF_alpha.
DR InterPro; IPR003438; GDNF_rcpt.
DR PANTHER; PTHR10269:SF15; GDNF FAMILY RECEPTOR ALPHA-3; 1.
DR PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR Pfam; PF02351; GDNF; 3.
DR PRINTS; PR01316; GDNFRECEPTOR.
DR SMART; SM00907; GDNF; 3.
DR SUPFAM; SSF110035; GDNF receptor-like; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 3..83
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 127..207
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 217..313
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
SQ SEQUENCE 322 AA; 36379 MW; 75253C37857A8EAA CRC64;
KDCIAAEEVC LSDPVCSATY QALENCSFDK TSFLPLKPHT RARCLDAELD LRSSSLLHCK
CRRRMRRQKH CLHIYWTVHS GFTQGYFNLE SSPYEDPAKE EPWKIDYNKL EALVSGRDHD
RSSENPCLKA THVCSLNSKC ARLRTDYASN CTKGAESGGT CDQRKCRQTL RHFFKKVPES
FTKRLLFCPC QDEFCGERRR KTIVPECSFQ NSIKPNCLLL LDSCRKDPIC RSQLADFQQN
CQPAAMSPDG CAQHNHAACL QAYMGMIGTG TAMTPNYVGN SSTEVSLWCT CENSGNQREE
CDQIHSMFIS NQCLTPALLC FG
//
