ID K7FRI7_PELSI Unreviewed; 814 AA.
AC K7FRI7;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=L3MBTL histone methyl-lysine binding protein 3 {ECO:0000313|Ensembl:ENSPSIP00000010647.1};
GN Name=L3MBTL3 {ECO:0000313|Ensembl:ENSPSIP00000010647.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000010647.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000010647.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AGCU01055872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01055873; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01055874; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01055875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01055876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01055877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01055878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006118644.1; XM_006118582.1.
DR RefSeq; XP_006118645.1; XM_006118583.2.
DR RefSeq; XP_006118647.1; XM_006118585.2.
DR RefSeq; XP_006118648.1; XM_006118586.2.
DR RefSeq; XP_014426757.1; XM_014571271.1.
DR RefSeq; XP_014426759.1; XM_014571273.1.
DR AlphaFoldDB; K7FRI7; -.
DR STRING; 13735.ENSPSIP00000010647; -.
DR Ensembl; ENSPSIT00000010700.1; ENSPSIP00000010647.1; ENSPSIG00000009472.1.
DR GeneID; 102463377; -.
DR KEGG; pss:102463377; -.
DR CTD; 84456; -.
DR eggNOG; KOG3766; Eukaryota.
DR GeneTree; ENSGT00940000159800; -.
DR HOGENOM; CLU_004064_0_1_1; -.
DR OMA; SADTMYH; -.
DR OrthoDB; 2905251at2759; -.
DR TreeFam; TF316498; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0140034; F:methylation-dependent protein binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0043249; P:erythrocyte maturation; IEA:Ensembl.
DR GO; GO:0030851; P:granulocyte differentiation; IEA:Ensembl.
DR GO; GO:0030225; P:macrophage differentiation; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:2000060; P:positive regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0090308; P:regulation of DNA methylation-dependent heterochromatin formation; IEA:Ensembl.
DR CDD; cd20132; MBT_L3MBTL3_rpt1; 1.
DR CDD; cd20135; MBT_L3MBTL3_rpt2; 1.
DR CDD; cd20138; MBT_L3MBTL3_rpt3; 1.
DR CDD; cd09582; SAM_Scm-like-3MBT3_4; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 4.10.320.30; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR002515; Znf_C2H2C.
DR PANTHER; PTHR12247:SF72; LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 3; 1.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR Pfam; PF02820; MBT; 3.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF01530; zf-C2HC; 1.
DR SMART; SM00561; MBT; 3.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 3.
DR PROSITE; PS51079; MBT; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS51802; ZF_CCHHC; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01143}.
FT REPEAT 209..309
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 317..416
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 425..520
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT DOMAIN 742..806
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 124..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..674
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 814 AA; 92131 MW; 8BEFE35B949631C5 CRC64;
MNESASSASG QEFDVFSVMD WKDGIGTLPG SDLKFRVNEF GALEVITDET EMESVKKATA
TTTWMVPTAQ EAFSEKTGIP LKLKETAKVD GHIFCENCYH YGTTEEFIPE GKFCSQKCAH
QVKNKGPKED KDDLECNEED DSKGTRKRKT KLPLKEECKE DEEDKREKDE MEEKHEGRIL
RVSQRARRKR KGDTAILKQP LYSKGKKPWC WASYLEEEKA AAAPTKLFKE YQSFPYGKNG
FKVGMKLEGV DPEHQSIYCV LTVAEVLGYR LRLHFDEYLD CYDFWVNADS SDIHPVGWCE
KTGHKLHPPK GYKEEEFNWS SYLKTCKAQA APKSLFENQN TTVIPSGFRV GMKLEAVDKK
NPTFICVATV TDMVDNRFLV HFDNWDESYD YWCEAASPHI HPIGWCKEHR RTLITPPDYP
HAKHFSWEKY LEETSSLPAP ARAFKVKPSH GFQKNMKLEV VDKRNPVLIR VATVVDIDDH
RIKVHFDGWD NIYDYWADAE SPDIHPAGWC AKTGHPLQPP LSPWELVEAL EHGGCPTAGC
KGVGHIKRAR HIGHHSVVSC PYSDVNLNKE RILPDRLSGE MPLASPSVPK NRKTDANERS
TSPVINDRKC PSPGHTGTKS SAPSRSSVKS VSDTTKQEDI ENKSPCKELL LCDAKDKKSS
RGGQQAKDSA KKEECEEEET ENELSTLNET RDIEEPNCQK PLLQPVFLSS KFQIPCLPLR
WEQQSKLLPS VAGIPASKVS KWSTDEVSEF IRSLPGCEEH GKVFKDEQID GEAFLLMTQA
DIVKIMSIKL GPALKIFNSI LMFKAAEKNS HNEL
//
