ID K7FSE5_PELSI Unreviewed; 843 AA.
AC K7FSE5;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Karyopherin subunit beta 1 {ECO:0000313|Ensembl:ENSPSIP00000010955.1};
GN Name=KPNB1 {ECO:0000313|Ensembl:ENSPSIP00000010955.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000010955.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000010955.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the importin beta family. Importin beta-1
CC subfamily. {ECO:0000256|ARBA:ARBA00010907}.
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DR EMBL; AGCU01094084; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01094085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FSE5; -.
DR STRING; 13735.ENSPSIP00000010955; -.
DR Ensembl; ENSPSIT00000011011.1; ENSPSIP00000010955.1; ENSPSIG00000009775.1.
DR eggNOG; KOG1241; Eukaryota.
DR GeneTree; ENSGT00550000074898; -.
DR HOGENOM; CLU_008296_1_0_1; -.
DR OMA; QQYQERW; -.
DR TreeFam; TF105655; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0071782; C:endoplasmic reticulum tubular network; IEA:Ensembl.
DR GO; GO:0042564; C:NLS-dependent protein nuclear import complex; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0051879; F:Hsp90 protein binding; IEA:Ensembl.
DR GO; GO:0061676; F:importin-alpha family protein binding; IEA:Ensembl.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:Ensembl.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030953; P:astral microtubule organization; IEA:Ensembl.
DR GO; GO:0040001; P:establishment of mitotic spindle localization; IEA:Ensembl.
DR GO; GO:0007079; P:mitotic chromosome movement towards spindle pole; IEA:Ensembl.
DR GO; GO:0007080; P:mitotic metaphase chromosome alignment; IEA:Ensembl.
DR GO; GO:0090307; P:mitotic spindle assembly; IEA:Ensembl.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IEA:Ensembl.
DR GO; GO:0031291; P:Ran protein signal transduction; IEA:Ensembl.
DR GO; GO:0006610; P:ribosomal protein import into nucleus; IEA:Ensembl.
DR GO; GO:0006404; P:RNA import into nucleus; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF1; IMPORTIN SUBUNIT BETA-1; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00185; ARM; 3.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 1..68
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT REPEAT 376..413
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ SEQUENCE 843 AA; 93528 MW; CF59974DEF025785 CRC64;
PTFLVELSRV LANPGNSQVA RVAAGLQIKN SLTSKDPDVK AQYQQRWLAI DANARREVKN
YVLQTLGTET YRPSSASQCV AGIACAEIPM NQWPELIPQL VANVTNQHST EHMKESTLEA
IGYICQDIDP EQLQDKSNEI LTAIIQGMRK EEPSNNVKLA ATNALLNSLE FTKANFDKES
ERHFIMQVVC EATQCPDTRV RVAALQNLVK IMSLYYQYME TYMGPALFAI TIEAMKSDID
EVALQGIEFW SNVCDEEMDL AIEASEAAEQ GRPPEHTSKF YAKGALQYLV PILTQTLTKQ
DENDDDDDWN PCKAAGVCLM LLATCCEDDI VPHVLPFIKE HIKNPDWRYR DAAVMAFGCI
LEGPEPNQLK PLVIQAMPTL IELMKDPSVV VRDTTAWTVG RICELLPEAA INDIYLAPLL
QCLIEGLSAE PRVASNVCWA FSSLAEAAYE AADVADDQEE PATYCLSSSF ELIVQKLLET
TDRPDGHQNN LRSAAYEALM EIVKNSAKDC YPAVQKTTLV IMERLQQVLQ MESHIQSTSD
RIQFNDLQSL LCATLQNVLR KVQHQDALQI SDVVMASLLR MFQSTAGSGG VQEDALMAVS
TLVEVLGGEF LKYMDAFKPF LGIGLKNYAE YQVCLAAVGL VGDLCRALQS NILPFCDEVM
QLLLENLGNE NVHRSVKPQI LSVFGDIALA IGGEFKKYLE VVLNTLQQAS QAQVDKSDYD
MVDYLNELRE GCLEAYTGII QGLKGDQENV HPDVMLVQPR VEFILSFIDH IAGDEDHTDG
VVACAAGLIG DLCTAFGKDV LKLVEARPMI HELLTEGRRS KTNKTKTLAT WATKELRKLK
NQA
//
