ID K7FSK6_PELSI Unreviewed; 487 AA.
AC K7FSK6;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=GRB2 associated binding protein 3 {ECO:0000313|Ensembl:ENSPSIP00000011016.1};
GN Name=GAB3 {ECO:0000313|Ensembl:ENSPSIP00000011016.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000011016.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000011016.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GAB family. {ECO:0000256|ARBA:ARBA00029462}.
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DR EMBL; AGCU01173155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01173156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01173157; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01173158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01173159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FSK6; -.
DR STRING; 13735.ENSPSIP00000011016; -.
DR Ensembl; ENSPSIT00000011072.1; ENSPSIP00000011016.1; ENSPSIG00000009983.1.
DR eggNOG; ENOG502QU11; Eukaryota.
DR GeneTree; ENSGT00940000159803; -.
DR HOGENOM; CLU_028652_1_0_1; -.
DR OMA; GRMCGNP; -.
DR TreeFam; TF329487; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR CDD; cd13385; PH_Gab3; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR046355; Gab1-4-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45960; GRB2-ASSOCIATED-BINDING PROTEIN; 1.
DR PANTHER; PTHR45960:SF3; GRB2-ASSOCIATED-BINDING PROTEIN 3; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 5..117
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 130..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..413
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..465
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 487 AA; 54260 MW; 5596201A1A56C755 CRC64;
MSSGDVVCTG WLIKSPPEKK LKRYAWRKRW FVLRRGRMSG NPDVLEYYRN NHSKKPIRII
DLNECEVLKH SGPNFIKKEF QNNFVFIVKT TYRSFYLVAK TEEEMQIWVH NISQICNFGH
LEDGTDSVES LSHTTSSLQP SPAISIHTSR ITDPSSSVGS ATTDASTAEE TRSESESVFL
PDYLFLSNCK TGKLNHTRCD SWSNSDRSLE QTSSDDVFVD ALQSQPSLHA LSSSNGIMHQ
DGGQPANHGI LPRSIDVNGP FSDVSSSSPL LGPPLTPTFQ IEKNQTTLPY GVTNLDILSN
TPPPRPPKPT HFSDRRGEEP PNVAFQNGHA GICRAQAALV PRRISLSSLD NVRHWKADME
GSSLRSRDKR LSLNLPCRFT PLYSSASDST EDSYVPMRPS TSPPIPGPDC SPDGYTPMSP
SSVTFTFPVV NNEKLSSPLP ELPTDLEPPP VNRDLKPRRK SRPPPLDLRN LSTIREHATL
TRMWTVP
//
