ID K7FT13_PELSI Unreviewed; 291 AA.
AC K7FT13;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Tumor suppressor candidate 3 {ECO:0000313|Ensembl:ENSPSIP00000011173.1};
GN Name=TUSC3 {ECO:0000313|Ensembl:ENSPSIP00000011173.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000011173.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000011173.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the OST3/OST6 family.
CC {ECO:0000256|ARBA:ARBA00009561}.
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DR EMBL; AGCU01122325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01122326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01122327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01122328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01122329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01122330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01122331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01122332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01122333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01122334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FT13; -.
DR STRING; 13735.ENSPSIP00000011173; -.
DR Ensembl; ENSPSIT00000011229.1; ENSPSIP00000011173.1; ENSPSIG00000010076.1.
DR eggNOG; KOG2603; Eukaryota.
DR GeneTree; ENSGT00390000012030; -.
DR HOGENOM; CLU_052855_0_0_1; -.
DR OMA; VLFGMYS; -.
DR TreeFam; TF314850; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0008250; C:oligosaccharyltransferase complex; IEA:Ensembl.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0050890; P:cognition; IEA:Ensembl.
DR GO; GO:0018279; P:protein N-linked glycosylation via asparagine; IEA:Ensembl.
DR CDD; cd02947; TRX_family; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR021149; OligosaccharylTrfase_OST3/OST6.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR12692; DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR12692:SF1; TUMOR SUPPRESSOR CANDIDATE 3; 1.
DR Pfam; PF04756; OST3_OST6; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 142..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 173..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 291 AA; 33101 MW; 0EA63D46D8ABDCA6 CRC64;
MEWSSRRSVI RMNGDKFRRF VKAPPRNYSV IVMFTALQPQ RQCSVCRQAN EEYQVLANSW
RYSSAFSNKL FFTIVDYDEG ADVFQQLNMN SAPTFMHFPP KGKPKRADTF DLQRIGFAAE
QLAKWIADRT DVHIRVFRPP NYSGTIALAL LVSLVGGLLY LRRNNLEFIY NKTGWAMAAL
CVVFAMTSGQ MWNHIRGPPY AHKNPQNGQV SYIHGSSQAQ FVAESHIILL LNAAITMGMV
LLNEAATSKG DVGKRRIICL VGLGLVVFFF SFLLSIFRSK YHGYPYSFLI K
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