ID K7FUY8_PELSI Unreviewed; 968 AA.
AC K7FUY8;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Sorting nexin 13 {ECO:0000313|Ensembl:ENSPSIP00000011848.1};
GN Name=SNX13 {ECO:0000313|Ensembl:ENSPSIP00000011848.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000011848.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000011848.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; AGCU01197374; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01197375; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01197376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01197377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01197378; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01197379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01197380; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01197381; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01197382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01197383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FUY8; -.
DR STRING; 13735.ENSPSIP00000011848; -.
DR Ensembl; ENSPSIT00000011905.1; ENSPSIP00000011848.1; ENSPSIG00000010516.1.
DR eggNOG; KOG2101; Eukaryota.
DR GeneTree; ENSGT00950000182856; -.
DR HOGENOM; CLU_005899_1_0_1; -.
DR OMA; EWTPTNV; -.
DR TreeFam; TF324055; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:Ensembl.
DR CDD; cd06873; PX_SNX13; 1.
DR CDD; cd08719; RGS_SNX13; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037437; SNX13_PX.
DR InterPro; IPR037896; SNX13_RGS.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF3; SORTING NEXIN-13; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 30..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 97..284
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 373..493
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 570..691
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 968 AA; 112251 MW; 69620340EEBCF0D9 CRC64;
FLFQTSLSIW GWGSLVVVLF LVTFGPFAIF YFAFYILCFV GGCFVVTLLF GKTNSEKYLE
QCEHSFLPPT SVGIFKCTEE MKCEARPIKI DRRLTGANII DEPLQQVIQF SLRDYVQYWY
YTLSDDESFL LEIRQALQNA LIQFSTRSKE IDWQPYFTTR LVDDFATHLR VFRKAQQRIT
EKDDQMTGTA EDLVDTFFEV EVEMEKEVCR DLVCTSPKDE EGFLRDLCEV LLYLLLPPGD
FQNKIMRYFV REILARGILL PLINQLSDPD YINQYVIWMI RDSNCNYEAF MNVLKLSDNA
GELEAVRDKA GEELQYLRSL DTAGDDINTI KNQINSLLYV IKVCDSRIQR LQSGKEIDTV
KLAANFGKLC TVPLDNILVD NVALQFFMDY MQQTGGQAHL FFWMTVEGYR VTAQQQLEVL
LSRQRDGKHQ TNQTKGLLRA AAVGIYEQYL SEKASPRVNI DDTLVAKLAE TLNNEDPTPE
IFDDIQRKVY ELMLRNERFY PSFKQNALYV RMLAELDMLK DPSFRGSDDG EGESFNGSPT
SSINLSLDDL SNVSSQDSAQ LHACISDTVY ADYDPYAVAG VCNDHGKTYA LYAITVHRRN
PTSEEIWKTY RRYSDFHDFH MRITEQFENL ASILKLPGKK TFNNMDREFL EKRKKDLNAY
LQLLLNPEMM KASPALAHCV YDFLENKAYS KGKGDFARKM DTFVNPLRNS MRNVSNAVKS
LPDSLAEGMT KMSDNMGKMS ERLGQDIKQS FFKVPPLVQK TDSDPEHCRV AAQLDDNVDD
NIPLRIMLLL MDEIFDLKER NQWLRRNIKN LLQQLIRATY GDTINRKIVD HVDWMTSPEQ
VADAVKRFRD AFWPNGILAE TVPRRDKAIR MRTRVAGKTK LLEIMPDELR HIIGAETTRK
GILRVFEMFQ HTQLNKRMVY VFLEGFLETL FPQYKFLELF SKLHSRSEQM QRYKQRLQPT
QAPSLQKR
//
