ID K7FVX2_PELSI Unreviewed; 823 AA.
AC K7FVX2;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Amyloid beta precursor protein binding family A member 1 {ECO:0000313|Ensembl:ENSPSIP00000012182.1};
GN Name=APBA1 {ECO:0000313|Ensembl:ENSPSIP00000012182.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000012182.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000012182.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01194649; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01194650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01194651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01194652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01194653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01194654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01194655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01194656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01194657; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01194658; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006137906.1; XM_006137844.2.
DR RefSeq; XP_014436472.1; XM_014580986.1.
DR RefSeq; XP_014436473.1; XM_014580987.1.
DR RefSeq; XP_014436474.1; XM_014580988.1.
DR RefSeq; XP_014436475.1; XM_014580989.1.
DR AlphaFoldDB; K7FVX2; -.
DR STRING; 13735.ENSPSIP00000012182; -.
DR Ensembl; ENSPSIT00000012240.1; ENSPSIP00000012182.1; ENSPSIG00000010992.1.
DR GeneID; 102458341; -.
DR KEGG; pss:102458341; -.
DR CTD; 320; -.
DR eggNOG; KOG3605; Eukaryota.
DR GeneTree; ENSGT00940000156820; -.
DR HOGENOM; CLU_013563_1_0_1; -.
DR OMA; SENCKDX; -.
DR OrthoDB; 2881953at2759; -.
DR TreeFam; TF315245; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0048787; C:presynaptic active zone membrane; IEA:Ensembl.
DR GO; GO:0098685; C:Schaffer collateral - CA1 synapse; IEA:Ensembl.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
DR GO; GO:0014051; P:gamma-aminobutyric acid secretion; IEA:Ensembl.
DR GO; GO:0014047; P:glutamate secretion; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:Ensembl.
DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:0099171; P:presynaptic modulation of chemical synaptic transmission; IEA:Ensembl.
DR GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR CDD; cd22578; Mint1_CID; 1.
DR CDD; cd00992; PDZ_signaling; 2.
DR CDD; cd01208; PTB_X11; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR12345:SF14; AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 1; 1.
DR PANTHER; PTHR12345; SYNTENIN RELATED; 1.
DR Pfam; PF00595; PDZ; 2.
DR Pfam; PF00640; PID; 1.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 2.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 443..629
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 642..727
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 733..809
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 823 AA; 91824 MW; 88EB0A03ADB421E2 CRC64;
MNHLEGPPQG EVNDEPANGE VNESVEADLE HSEVEEEQQQ YATHYPRHAS GSQGQSGQEE
EGMLARSAST ESGFHNHTDT AEGDVIATAE YGYDTDRVQE NEDESAYAVQ YRPESEEYTE
NAEAEHAEAT HARTLPNHLH FHSIEHEEAM NAAYSGYVYT HGLFHRGEDE QYAEPYADYG
LQEHVYEEIG DAPDLDVREG LRLYEQEREE ADNYRKEALG ARLHHYDERS DGESDSPEKE
AEFAPYPRMD SYEQEEDIDQ IVAEVKQSMS SQSLDKLAED MPEAEQNLEC AHTPSRGTLE
SNGQLPTGSR PTANSGESVQ RYSKEKRDAI SLAIKDIKEA IEEVKTRTIR SPYTPDEPKE
PIWVMRQDIS PTRDCDDQRP LDGDSPSPDS SSPRGAESSS RQHHQDVCGT AEPSTNKESR
KSLASFPTYV EVPGPCDPED LIDGIIFAAN YLGSTQLLSD KTPSKNVRMM QAQEAVSRIK
MAQKLAKSRK KAPEGESQPM TEVDLFISTQ RIKVLNADTQ ETMMDHPLRT ISYIADIGNI
VVLMARRRMP RSNSQDNVEA SHPSQDGKRQ YKMICHVFES EDAQLIAQSI GQAFSVAYQE
FLRANGINPE DLSQKEYSDL LNTQDMYNDD LIHFSKSENC KDVYIEKQKG EILGVVIVES
GWGSILPTVI IANMMHGGPA EKSGKLNIGD QIMSINGTSL VGLPLSTCQS IIKGLKNQAR
VKLNIVRCPP VTTVLIRRPD LRYQLGFSVQ NGIICSLMRG GIAERGGVRV GHRIIEINGQ
SVVATPHEKI VHILSNAVGE IHMKTMPAAM YRLLTAQEQP VYI
//
