ID K7FX77_PELSI Unreviewed; 1237 AA.
AC K7FX77;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=CASK interacting protein 2 {ECO:0000313|Ensembl:ENSPSIP00000012637.1};
GN Name=CASKIN2 {ECO:0000313|Ensembl:ENSPSIP00000012637.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000012637.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000012637.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AGCU01174094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01174095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01174096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FX77; -.
DR STRING; 13735.ENSPSIP00000012637; -.
DR Ensembl; ENSPSIT00000012698.1; ENSPSIP00000012637.1; ENSPSIG00000011273.1.
DR eggNOG; KOG0507; Eukaryota.
DR GeneTree; ENSGT00940000158256; -.
DR HOGENOM; CLU_003619_1_1_1; -.
DR OMA; PRCKERE; -.
DR TreeFam; TF320582; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd09497; SAM_caskin1_2_repeat1; 1.
DR CDD; cd09498; SAM_caskin1_2_repeat2; 1.
DR CDD; cd12063; SH3_Caskin2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR033635; ANKS1/Caskin.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032232; Caskin1-CID.
DR InterPro; IPR035497; Caskin1/2_SAM_1.
DR InterPro; IPR035498; Caskin1/2_SAM_2.
DR InterPro; IPR035499; Caskin2_SH3.
DR InterPro; IPR032117; Caskin_C.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24174; ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR24174:SF18; CASKIN-2; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF16907; Caskin-Pro-rich; 1.
DR Pfam; PF16632; Caskin-tail; 1.
DR Pfam; PF16600; Caskin1-CID; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT REPEAT 48..80
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 81..113
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 114..146
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 188..220
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 220..252
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 281..347
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 497..560
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 566..630
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 353..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..1001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1178..1205
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 390..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..881
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 911..928
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..947
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..980
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1237 AA; 134579 MW; 78E52F7E1190F8A0 CRC64;
AGGRKGCWAR ARSGTCRSVQ KKLKWKKTTK GELLGSAKRL NVNYQDADGF SALHHAALGG
SLELISLLLE AQATVDIKDS NGMRPLHYAA WQGRVEPVLL LLRAAASVNM ASLDGQIPLH
LSAQYGHYEV SEMLLQHQSN PCLINKAKKT PLDLACEFGR LKVAQLLLNS HMCVALLEGQ
SKDMSDPNYT TPLHLAAKNG HKEIIRQLLK AGIEINRQTK TGTALHEAAL YGKTEVVRLL
LEGGVDVNIR NTYNQTALDI VNQFTTSHAS KDIKQLLREA SGILKVRALK DFWNLHDPTA
LNIRAGDVIT VLEQHSDGRW KGHIHDTQKG TDRVGYFPPS IVEVISKRTG MTLPRTVPAN
HRQGVAGSAD APQQAPLSLP AAYSHLTLTR TAPGPENSGD RNSVGSEGSI GSIRSAGSGQ
STEGTNGQST SILIENAKPL PPGGEDLPQQ LLGLTSPNGQ LSSMTGTLGR QNLANCNASN
RMFSHQYLHP DQLLEGKDAE AIYNWLSEFQ LEFYAANFLS AGYDVPTISR MTPEDLTAIG
VTKPGHRKKI STEIGQLSIA EWLPNYIPAD LMEWLSAIGL PQYHKKLVSN GYDSVSIVMD
LTWEDLQEIG INKLGHQKKI MLAVKKLTDL RKYLNQADTN EAQRKIPGTL DIVTIESLEN
GEGQSPHTPK MKTFLDSELS YELQTAMSNS CQETLPMKST QGMSRSQESI GVRSRGSGHS
QLTAQEALNG YSNGCGGSPL KERNLPEGMA TTPYTPPQTP TKNTAPYVFM YPHISLKSPT
APEQPSSAQK AFSYLHSHCS GTDSPYVSPG SWHTGDLQNG DPFKYKKRSH SLNRYALSDS
EHEKEEEPSS TLGSYATLTR RPGRSQVPRT YLQSDTKVVR SQSFAIRAKR KGPPPPPPKR
LSSVSSAQAV EAEDNDRDAF ESSRPRRRTF SEPSGTMTEA SQSSLEDVQS DTEEELRPGP
EDCVVSSSSS QNSSSECIPF AEEGNLTIKQ RPKPTGQHKK ELGGTTTEVL EFNLTESDTV
KRRPRYKERE PLQTLLKAFS LAGQSQALAS PPQQYAQAPA VSVASPVLQV PEPEPGGAGD
VFDDDSVEFR IATPLPCVAQ GVSAAAWCFC GGTREELCPS QLGWVSPGPD ASAKHTSVAS
TKLVFSGPKT IYQQVLQPSR NTVAPWPLND APDAALAQQR LEQTNSSLAA ALQAAEKKIT
AEEAESVPRT THLAKNILED ISNMFDDLAD QLDAMLD
//
