ID K7FXH4_PELSI Unreviewed; 935 AA.
AC K7FXH4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Alpha-2-macroglobulin bait region domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000012734.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000012734.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01173971; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01173972; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01173973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FXH4; -.
DR STRING; 13735.ENSPSIP00000012734; -.
DR Ensembl; ENSPSIT00000012795.1; ENSPSIP00000012734.1; ENSPSIG00000011458.1.
DR eggNOG; KOG1366; Eukaryota.
DR GeneTree; ENSGT00940000158779; -.
DR HOGENOM; CLU_001634_2_0_1; -.
DR OMA; YMAQISV; -.
DR TreeFam; TF313285; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR PANTHER; PTHR11412:SF170; OVOSTATIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SUPFAM; SSF81296; E set domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..935
FT /note="Alpha-2-macroglobulin bait region domain-containing
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003902255"
FT DOMAIN 447..594
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 732..822
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 935 AA; 104863 MW; 235E3ABDD5202BE6 CRC64;
MWLRFFMSTL LLHLTAASPP ELQYSLMVPS VLQSNSPDQA CIQIHNLNES VSMSIALEYS
NANTTILEQS VKGNYFFKCI RFMAPRATAS PLAFVTFSAK GATVRLAERR SVAIQNVESI
VFVQTDKPIY KPRQTVLLRV VAIDTQFKPV QEMYPLITIQ DPQGNRIFQW LNVTSRKAIV
QLTFQLIEEP MLGSYQIIVG KKSGTSIHYS FTVDEYVLPK FEVMVHAPKS VTVLTPDFTV
KVCGVYTYGQ PVEGRVQLSV CRDFSLYGSC KRDPLCQSVT KAMGKDGCIS HVFSSKIFEL
NRAGYQMSLV VEAIVTEKGT GVRLTGSAYI TVTQVLGSVR FENMDQSYKR GIPYFGQIKL
VNEDDLPIAN EVVQLLLNDK NVGNYTTDGN GTIEFSVDTS EMFNPQFSLR AIYKTSDICN
IVGWLVPFYP EAYYYVQRFY SRTNSFVKIK LEPERLRCGQ KRSITVYYVL NKKGYEKLTQ
VKFYYVVMVK GKIVLSGQKH VNTSRALKGT FSIPLAVSEK IAPAARMLVY TVHPSKELVA
DSARFQIEKC FKNKVRLQFS VKQGLPASNV SLHVEAAANS QCALLAVDES VLLLKPEQEL
SAETVYNLLP FQDLSGYHFS GLNLEDDSKE PCVPADNIFY NGLYYMPVSS DFGPDVYLYF
KEMGMKVLTN SHLRQPVVCG SVRPTPDFLS RPGFGESLST PMATAKLSET VSADDSQDRI
ITEIIRKYFP ETWIWDLVLL NSIGEANIVF TIPDTITKWK ASVFCLEKKA GFGISAPTFL
SAFQPFFVDM TLPFSIIRGE DFLLRANIFN YLDKCIMVSI LLASSQDYQA QLLSPEGDDG
CVCANERKTY VWNIISKKLG DVIFSVTAET KQNASKCENR TSGRPEAGWK DTLIRTLLVE
EISWARPCRT CSSSSRCPLA AGSRTWSCLP PISTF
//
