ID K7FXU8_PELSI Unreviewed; 3083 AA.
AC K7FXU8;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=BRCA2 DNA repair associated {ECO:0000313|Ensembl:ENSPSIP00000012858.1};
GN Name=BRCA2 {ECO:0000313|Ensembl:ENSPSIP00000012858.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000012858.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000012858.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01101782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01101783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01101784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01101785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01101786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01101787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 13735.ENSPSIP00000012858; -.
DR Ensembl; ENSPSIT00000012919.1; ENSPSIP00000012858.1; ENSPSIG00000011574.1.
DR eggNOG; KOG4751; Eukaryota.
DR GeneTree; ENSGT00390000003602; -.
DR HOGENOM; CLU_000344_0_0_1; -.
DR OMA; CWYTKLG; -.
DR TreeFam; TF105041; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0033593; C:BRCA2-MAGE-D1 complex; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:1990391; C:DNA repair complex; IEA:Ensembl.
DR GO; GO:0000800; C:lateral element; IEA:Ensembl.
DR GO; GO:0000152; C:nuclear ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:Ensembl.
DR GO; GO:0010484; F:histone H3 acetyltransferase activity; IEA:Ensembl.
DR GO; GO:0010485; F:histone H4 acetyltransferase activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0071479; P:cellular response to ionizing radiation; IEA:Ensembl.
DR GO; GO:0090398; P:cellular senescence; IEA:Ensembl.
DR GO; GO:0051298; P:centrosome duplication; IEA:Ensembl.
DR GO; GO:0043009; P:chordate embryonic development; IEA:Ensembl.
DR GO; GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IEA:Ensembl.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0070200; P:establishment of protein localization to telomere; IEA:Ensembl.
DR GO; GO:0008585; P:female gonad development; IEA:Ensembl.
DR GO; GO:0071425; P:hematopoietic stem cell proliferation; IEA:Ensembl.
DR GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
DR GO; GO:0007141; P:male meiosis I; IEA:Ensembl.
DR GO; GO:1990426; P:mitotic recombination-dependent replication fork processing; IEA:Ensembl.
DR GO; GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:Ensembl.
DR GO; GO:0001556; P:oocyte maturation; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0032465; P:regulation of cytokinesis; IEA:Ensembl.
DR GO; GO:0010332; P:response to gamma radiation; IEA:Ensembl.
DR GO; GO:0010225; P:response to UV-C; IEA:Ensembl.
DR GO; GO:0010165; P:response to X-ray; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR GO; GO:0000722; P:telomere maintenance via recombination; IEA:Ensembl.
DR CDD; cd04493; BRCA2DBD_OB1; 1.
DR CDD; cd04494; BRCA2DBD_OB2; 1.
DR CDD; cd04495; BRCA2DBD_OB3; 1.
DR Gene3D; 6.10.70.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR015252; BRCA2_hlx.
DR InterPro; IPR036315; BRCA2_hlx_sf.
DR InterPro; IPR015187; BRCA2_OB_1.
DR InterPro; IPR048262; BRCA2_OB_2_dom.
DR InterPro; IPR015188; BRCA2_OB_3.
DR InterPro; IPR002093; BRCA2_repeat.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR015205; Tower_dom.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF09169; BRCA-2_helical; 1.
DR Pfam; PF09103; BRCA-2_OB1; 1.
DR Pfam; PF09104; BRCA-2_OB3; 1.
DR Pfam; PF00634; BRCA2; 4.
DR Pfam; PF21318; BRCA2DBD_OB2; 1.
DR Pfam; PF09121; Tower; 1.
DR PIRSF; PIRSF002397; BRCA2; 2.
DR SMART; SM01341; Tower; 1.
DR SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR PROSITE; PS50138; BRCA2_REPEAT; 4.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2481..2522
FT /note="Tower"
FT /evidence="ECO:0000259|SMART:SM01341"
FT REGION 1531..1551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3045..3083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1531..1545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3083 AA; 347946 MW; B235FCD62E77A46D CRC64;
MENKMADKPV ARPTFFEIFK ARCSESDLGP ISLNWFEELS TEALPYESET SERPEYRAVC
LEQSASKTPR GKPFTCSQLA STPVIFKEQS ITLPLLSSPI KELGQKKTET GKDSLVNKDH
RSSPHFMKTK LDQISPLNTS LSISSAALRG IYRTPQRNNI PVARGSLFCT PKLLEVKTPT
CISEGLGAEV DPDMSWSSSL ATPPTLSATV IIARGNDSIS GAKQHDERIA MVLHSFFSSH
GKRPEKNDVN VLSIPEIVNI NAGLDGKDHE LEKILDGSFG EMNSLENRSG RNQITQNSLE
DGERNEMRID MPDAGEHVLS VCHTSGEHLQ DVTMTNWTKK THFDKMATIL LQETNEIRGN
FKDASSVCER ELDSPRCEIF TTNMSNNRIP KLLENRKFTK EDMPSTFTSE WSQLNLSGLD
VTQLEKNSTS DKYSPSSFCN KKRSENKLHA NLSTFETSLL NTSSLIKAEK LLNINWSEHM
EDETKNYEKH STSETSIMHS VDLSVQDPSL VKVCAAEKVS EVHFLDCSSF LMENTNFTGY
TEVCTSCFHK ELKELSKSSI TDVTSHPVLC NDSIPSNPDG TKWSTNNEST PVRSCLKNTS
LLSSLKKRSK RFIYTINNAS PRQEEKVKKE IKAGPSIHSA SSRLEFESCP FKSPDMVSND
DQDLLVSSAE RKSLKSNSEE SFMLLSKYAT RADRIDNSPN SSLKNKMIHL DILKSNRREH
QPASSLDCSE TSNTLKECLV VSSNSNNVLS VEHKVIATAC LRATKHSEMD FVRTEHVVQW
PKKDEMEMYG NVNPHNDTVI LQTFKNQLGE PSSDNEQLVE IEQEQVSMKN RYFNDTSINC
DIHKHNSVCC NRTKSEDEND ATGLLPTDEW KTVTLPPLII QSNKNSSTTT LIRESKKDTV
QFSKVIVADQ ETESIENGDN NLQTPSNNNM VTIESSEKLF DHNNCGSLQA VISDKSTLPQ
LALKIGPEQI VSDFVTKAPE PNVEDKDFVK KVITFPSKRV TSDKYLYSKN HLCLDIKSKE
NPEDKEKWSG DTNFNGQCLN KCFGGFQTAS NKQIKVSEKS ITKGKMLFKD MEDECLKDFS
GEGIKNISNQ ITKKNINIVN NKLDTNYSHG LDSQASLIES KNAQSIVPES TDSSLQSLHR
NQPHQLNQTL TASQEAEITE LSNILEETNS QFEFTQFRKQ SNMVQNNSSQ LSGCVDKNET
TNLKDISAMW QDTDLDYISE TEAQRVNDKS SSKHTDINEE STEMGNVNEE REIFQKNNCV
EFTSTNLCRN ANKIPLVSSF SVSTQDNFSN FAGFSSAGGK KINISNEALI RAAKLFSNLD
AAAADDDDMF KPTEINSRSH YSDRYKTSRR DVSRCVAEGD SYCGESVKDA NIEYQNTLKN
NEENINTFMK IYGENQGENT TNISENDRVS SSTKISNLGV IKYSVYKMEN GLSSSENNNP
SLNISKKLHE SDTQSQYSLQ EGLSDLTCLA EVSKTEEILT LNISDDPSKS EQKIKNVDFR
TASSSNRSVS QAPLDKFHLF ETCTEKELNN ISSNSNSQMT HSINKKERNA TSRKRNINVN
QNKSRIGSGH QQISIQQDTD FERKNIEENN GFHTANGKKI IITDESLSKA KQFFAEENVC
PENMDNIGNF EDSEFHPCNK DFIKDCEEFA ENTPNYDQEM LTLTVGDQGV KFVGPGSTSA
LRKSEVVISQ KRDPKPELIS KTTFGFNTAS GKRVLVSENA FQKVKQVFNN SKYHFADRLS
SRQDPVIALK SSINYAGANK ATDTVCLKPK IQDTHNEELD LTNSYPVEIK ALQNICNIEI
PVCVPRSEKD EHLTLINSFT FAEDTQLFKK EHHSLTRMEI EAVSCNTPTK TKLDVFHLKC
SQSSEEYLET EAVESAKAFM EDKFTNSGIE NDTKKSLFIC RKIDKNCPLN IRTGKRHMEE
RASLGEPPIK RQLLPEFDRT ENPHKSLKAS KSTPDGMIKD RRKFMYHIPL KPETCVPFSA
TKERQEIKNP NITVLDQDFK GYKPKSDVFQ HHLLRQSLSG SSGFFTPFKK ISTEESEKRK
NLPLLSKTAK TFVPPFKVKS AISTHQHHVS KRLDSLINTT MNRDKELKDI TMQQSTSETE
VQSQEKDYTK QVAPCNLRNN VDGDSDLMEM IANLHYVRNL QEMRIRKKQR QNIHPQPGNL
YLMKTSAAKR ISLKAAVEEK TPSTYSMEQL YMYGVSKDCI KVNSINAESF QFLILDFFSK
EYLVAERGIQ LADGGWLIPT DKGMAGKEEF YRALCDTPGV DPKLITEAWV YNHYRWIVWK
LAAMEVSFPQ EFANRCLTPE RVLFQLKYRY DLEIDKSQRS AIKKIVERDD TPAKTLILCV
SKIILLNANM PDVCSNKTIV ENKKEAAIIE VTDGWYCIRA LLDPPLQALL HGRRLTVGQK
IIVHGAELVG SQDACTPLEI PDSLMLKISA NSTRRARWHA KLGFHQDPRP FPLPLSSLFG
EGGTVGCIDI VIQRTYPIQW VEKMPTGSYV FRNGRAEERE AAKHAENRQK HLEALFSQIQ
MEFEQHEDKP HKRALRSHTL TREQIRILED GAELYEVIQN ASDPSYVEGY LSEEQLKALN
THRQILNDKK QSEIQAEFKK AIESAEREER GCSKRDVSTV WKLRVIDYRK RETDKAIILS
IWRPLSDICS LLKEGGRYRI YQLTASRSKG KPDAVNCTLT ATKKTQYLQL QASQEVLLEI
YIPRKALQFS MLLDPSFRPS CAEVDLVGFI ISVSKKTGFT TLVYLSDEDH NLVAIKFWTD
LKQLAIEDII NPFTLISASN LQWRSEFKSD IPTLFAGDLS IFSASPKDSY LQERLNKLKN
TTENLSCFCS DAEHKLMKFL QKNSPQQYNL PKECGLDPLS PSWKSGLDTG NKPLISSPSS
EIKCQSSLST SKHDLKLVLR SSAKMTPHIS YSKESPKNCK KRRKALDLLS QIPSPPPVTP
INSFVSPSLK KAFQPPRSSG VQYDASLKRT NHNSDHINSF KGVNETDSLP NNDLVADEEL
AMINTQVLLY NFQEGKKTDC VGESTNPSDH LLLKNNCLMS LMETKTSQNS TDGAAALEKD
TRETEGSLPV QKKLQRQRKR KCY
//
