ID K7FYZ6_PELSI Unreviewed; 378 AA.
AC K7FYZ6;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Arf-GAP with dual PH domain-containing protein 1-like {ECO:0000313|Ensembl:ENSPSIP00000013256.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000013256.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000013256.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01057883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006118989.1; XM_006118927.2.
DR AlphaFoldDB; K7FYZ6; -.
DR STRING; 13735.ENSPSIP00000013256; -.
DR Ensembl; ENSPSIT00000013319.1; ENSPSIP00000013256.1; ENSPSIG00000011759.1.
DR GeneID; 102460744; -.
DR KEGG; pss:102460744; -.
DR eggNOG; KOG0703; Eukaryota.
DR GeneTree; ENSGT00940000167130; -.
DR HOGENOM; CLU_061583_0_0_1; -.
DR OMA; RAVQFHY; -.
DR OrthoDB; 1022106at2759; -.
DR TreeFam; TF324540; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:1902936; F:phosphatidylinositol bisphosphate binding; IEA:InterPro.
DR CDD; cd08832; ArfGap_ADAP; 1.
DR CDD; cd13252; PH1_ADAP; 1.
DR CDD; cd01251; PH2_ADAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037849; PH1_ADAP.
DR InterPro; IPR037851; PH2_ADAP.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46021; ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN; 1.
DR PANTHER; PTHR46021:SF1; ARFGAP WITH DUAL PH DOMAINS 1; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 2.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 6..129
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 132..233
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 255..360
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 378 AA; 44117 MW; AFAC578FA980AA63 CRC64;
MAGTDDKNTK TLREVWRRAE NALCADCEKP DPDWASYTLG VFICLNCSGI HRNIPNISKV
KSLRMDHWDE VQVQFLEQHG NAVAKATYEA HIPIYYYQPT YADCQALREQ WIRAKYERKE
FTEPGRELPY SNGLKEGILW KRGRDNGQFL PRRFLLSERE GCLKYFAKPD AKEPKINIKI
DTINATFQPV KIRNPNGLQI SYLKDNKTRN IFLYHEDGKE IVDWFNAIRA VQFHYLKVAF
PIAGDSEIKS RLMQNFLKEG YMEKTGPKQR EAFKKRWFTL DRRRLMYFKD PLDAFAKGEV
FVGSRKQGYS VNPGLPPGTQ GSFSWQYGLT IVTPDREYLF TCETESDQQD WIVAFSQVIE
QPMTPQEYAI EAYFKLSS
//
