ID K7FZ61_PELSI Unreviewed; 770 AA.
AC K7FZ61;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Leucine rich repeat containing G protein-coupled receptor 6 {ECO:0000313|Ensembl:ENSPSIP00000013321.1};
GN Name=LGR6 {ECO:0000313|Ensembl:ENSPSIP00000013321.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000013321.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000013321.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AGCU01037459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01037460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01037461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01037462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01037463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01037464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01037465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01037466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01037467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FZ61; -.
DR STRING; 13735.ENSPSIP00000013321; -.
DR Ensembl; ENSPSIT00000013384.1; ENSPSIP00000013321.1; ENSPSIG00000011884.1.
DR eggNOG; KOG0619; Eukaryota.
DR eggNOG; KOG2087; Eukaryota.
DR GeneTree; ENSGT00940000159939; -.
DR HOGENOM; CLU_006843_0_0_1; -.
DR OMA; YGVCAGF; -.
DR TreeFam; TF316814; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031982; C:vesicle; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0016500; F:protein-hormone receptor activity; IEA:InterPro.
DR GO; GO:1990523; P:bone regeneration; IEA:Ensembl.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0030177; P:positive regulation of Wnt signaling pathway; IEA:Ensembl.
DR CDD; cd15362; 7tmA_LGR6; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002131; Gphrmn_rcpt_fam.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24372; GLYCOPROTEIN HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24372:SF77; GPR INSULIN LIKE RECEPTOR 1; 1.
DR Pfam; PF13855; LRR_8; 3.
DR PRINTS; PR00373; GLYCHORMONER.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 10.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS51450; LRR; 4.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 419..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 455..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 511..532
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..571
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 591..616
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 637..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 672..692
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 435..689
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 770 AA; 85006 MW; AD6F99B254C9CDC3 CRC64;
RLDANLISVV PERSFEGLSS LRHLWLDDNA LTELPVQALN NLPTLQAMTL ALNLIWHIPD
YAFQNLSSLV VLHLHNNRIQ SLGINSFEGL HSLETLDLNY NKLLEFPVAV RTLGRLQELG
FHHNHIQAIP EKAFVGNPLL QTIHFYDNPI QFVGQSAFQF LPKLHTLSLN GARDIREFPD
LKGTTSLEIL TLTRAGIRLL PRGMCQQLPS LRVLELSHNQ IEELPSLHRC QRLEEIGLQH
NRIHEIRADT FGQLAALRSI DLSWNYIQSI HPEAFATLHA LTKLDLTVNQ LVSLPLDGLA
GLTHLKLQGN PALSEPFSKE SFPRMRILEV PYAYQCCAYG ACSNFFKVSS QWETEDMSLE
DEEARKRSTG LFPGHTENHY DLDMDDFQLE FEESKLHTTI QCTPSPGPFK PCDQLFESWI
IRLGVWAIAL VSILCNGLVS LAVFASPSYL SPVKFIIGSI AGANTLTGIY CSMLAFVDAL
TYGQFAKYGA RWESGAGCRV TGFLSVFASE AAILLLMVAA VQCSAAVSCF RLHGKPPSCG
SVKAATLGCL ALSAALALSA AAAALPLFSI GEYGTSPLCL PSPIPDGKSS TLGFTVALLM
VNTLCFLIIT STYIRLYCSL LKGEFDPIWD CAMIKHVAWL IFTNCLLYCP VAFLTLSSML
SLFLITPEVI KSVLLVVLPL PACLNPLLYL VFNPHFRDDL RLLRQRGQAK SSCPRACVSD
VMEKTSYDST QALVTFSDAD HVAEVPDALH GPPSLGAYRF PSVRLLPCPQ
//
