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Database: UniProt
Entry: K7FZC4_PELSI
LinkDB: K7FZC4_PELSI
Original site: K7FZC4_PELSI 
ID   K7FZC4_PELSI            Unreviewed;      4872 AA.
AC   K7FZC4;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   16-JAN-2019, entry version 44.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSPSIP00000013384};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSPSIP00000013384};
OS   Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudines; Cryptodira; Trionychia; Trionychidae;
OC   Pelodiscus.
OX   NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000013384, ECO:0000313|Proteomes:UP000007267};
RN   [1] {ECO:0000313|Ensembl:ENSPSIP00000013384}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17381049; DOI=10.1080/10425170600760091;
RA   Jung S.-O., Lee Y.-M., Kartavtsev Y., Park I.-S., Kim D.S., Lee J.-S.;
RT   "The complete mitochondrial genome of the Korean soft-shelled turtle
RT   Pelodiscus sinensis (Testudines, Trionychidae).";
RL   DNA Seq. 17:471-483(2006).
RN   [2] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG   Soft-shell Turtle Genome Consortium;
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSPSIP00000013384}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AGCU01150325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01150326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01150327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01150328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01150329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01150330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01150331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01150332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01150333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01150334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 13735.ENSPSIP00000013384; -.
DR   Ensembl; ENSPSIT00000013447; ENSPSIP00000013384; ENSPSIG00000011297.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00940000155507; -.
DR   OMA; PLLNEYC; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000007267; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007267};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4186   4210       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4412   4432       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4479   4498       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4673   4694       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4753   4776       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      100    155       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      162    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      215    269       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      275    333       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      343    400       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      585    796       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1002   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1254   1468       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3923   3958       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      459    479       {ECO:0000256|SAM:Coils}.
FT   COILED     2959   2979       {ECO:0000256|SAM:Coils}.
FT   COILED     3224   3244       {ECO:0000256|SAM:Coils}.
FT   COILED     3592   3614       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4872 AA;  553154 MW;  9FA12DB6788363DC CRC64;
     MAEGGEGGED EIQFLRTDDE VVLQCVANIQ KEQRKFCLAA EGLGNRLCFL EPTSEAKYVP
     PDLCICNFVL EQSLSVRALQ EMLANTGENA SEGAVQGGGH RTLLYGHAIL LRHSFSRMYL
     TCLSTSRSQT DKLAFDVGLR ENAAGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER
     YLHLSMSNGN VEVDASFMQT LWNVHPTCSG SNTEEGYLLG GHVVRFFHGH DECLTIPSTD
     QNDSQQKRVL YETGGAGVRA RSLWRVEPLR ISWSGSYIKW GQPFRLRHIT TGQYLALSED
     QGLVLFDRGK SDTQSTSFCF RASKKLKEKL DSAHKRDIEG MGVAEIKYGD SVCFVQHVAS
     ALWLTYLAQD AKAPRLGPLK RKVILHQEGH MDDGLTLQRC QHEESQAARI IRNTTGLFSQ
     FISGNNRTAA PVALPIEEVL ETLQDLITYF QPPAEELGHE DKQNKLRSLK NRQNLFKEEG
     MLALVLNCID RLNVYNSAAH FAGIAREESG TAWKEILNLL YKLLAALIRG NRNNCTQFSN
     NLDWLISKLD RLESSSGILE VLHCILIESP EALNLIAEEH IKSIISLLDK HGRNHKVLDV
     LCSLCLCNGV AVRANQNLIC DNLLPRRDLL LQTRLINDVT SMRPNIFLGV AEGSAQYKKW
     YFELIIDQVD PFLTAEPTHL RVGWASTSGY APYPGGGEGW GGNGVGDDLH SYGFDGLHLW
     SGRVPRAVAS VNQHLLASDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN VDGLFFPVVS
     FSAGVKVRFL LGGRHGEFKF LPPTGYAPCY EALLPKEKMK LEPVKEYKRD SDGVRDLLGT
     TQFLSQASFI PCPIDTTQVV LPPQLEKIRD KLAENIHELW GMNKIELGWT YGKIRDDNKR
     QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIVHA NPAAEEDLKK VKLSKNYIMS
     NGYKPAPLDL SEVKLLPSQE VLVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV
     PYALLDERTK KSNRDSLREA VRTFAGYGYN IEPPDQELTD QTMEKISIDK IRCFRIEQSY
     AVSSGKWYFE FEAVTGGDMR VGWARPGCRP DIELGADDQA FVFEGSRGRR WHQGSGFFGR
     NWQPGDVVGC MINLDDKSMI FTLNGELLIT NKGSELAFAD FEIDKGFVPI CSLSLSQIGR
     MNLGMDASTF KYYTMCGLQE GFEPFAVNMN RDVAMWFSKR LPTFVNVPKN HAHIEITRID
     GTIDSPPCLK VTHKTFGTQN SNADMIYCRL SMPIEFHSTF NYGTGVESAS ADTFQKRLDS
     ILHYFLSFQY YYSVRIFAGQ DPSSVWVGWV TPDYHYYSEN FDLNKNSTVT VTLGDERGRV
     HESVKRSNCY MVWGGDTFAN SQRSSRSNVD LEIGCIVDLG TGMLSFTANG KDLGTCYQVE
     PTTKLFPAVF IQPTSTNLVL FQLGKLKNTM PLSAAIFKSE EKNPIPQCPP RLDVQTITPV
     LWSRMPNNFL KVETERISER HGWVVQCLEP LQMMALHIPE ENRCVDILEL CEQEDLMQFH
     YHTLKLYSSV CALGNNRVAY ALCSHVDLSQ LFYTIDNQYL PGLLRSGFYD LLISIHLEHA
     KEAKLMMNNE FIIPITDETR KIKLYPDESK IHGLPGVGLS TCLKPGFYFS TPCFIAASEE
     HQKPSPEIPL EILKIKAISM LTEAVHGSGV HIRDPVGGKV EFQFVPVLKL IGTLLIMGVF
     DDDDVKQILL LIDPNVFGEH KEETEEKTEK EEVTQIEEKA VEAGEEALKE TKPPIKGLLQ
     TRLPESVKLQ MCELLNYFCD CELRHRVEAI VSFADNYVSK LQYNQKYRYN ELMQALNMSA
     ALTAKKTKEF RSPPQEQINM LLNFQLREDC PCPEEIREEL YEFHDDLLIH CGIPLEEEEE
     MEEDSSWTGK LRSLIYKIKG PPKAEKKEPT EEEEKSPTTL KELISQTMVR WAQEDQIQDP
     ELVRIMFNLL RRQYDSIGEL LQALRKAYTI SAASVQDTIN LLAALGQIRS LLSVRMGKEE
     ELLMINGLGD IMNNKVFYQH PNLMRILGMH ETVMEVMVNV LGGDKSQIAF PKMVASCCRF
     LCYFCRISRQ NQKAMFEHLS YLLENSSVGL ASPSMRGSTP LDVAAASVMD NNELALALEE
     PDLEKKQVVT YLAGCGLQSC PMLVAKGYPD IGWNPIEGER YLSFLRFAVF VNSESVEENA
     SVVVKLLIRR PECFGPALRG EGGSGLLTAM QEAIKISENP TLDLPCQDYA DEVSSAEEDE
     EEIVHMGNAI MSFYSALIDL LGRCAPEMHL IQTGKGEAIR IRSILRSLVP TEDLVGIISI
     PLKLSTVNKD GTVTEPDMSA SFCPDHKAPM VLFLDRVYGI KDQSFLLHLL EVGFLQDLRA
     SASLDTVSLS TTEAALALNR YICSSVLPLL TRCAPLFSGT EHYASLIDST LHTIYRLSKG
     RSLTKAQRDT IEDCLLAVCH HLRPSMLQQL LRRLVFDVPL LNQYCKMPLK LLTNHYEQCW
     KYYCLPTGLG SYGIAAEEEL HLTEKLFWGI FDSLSHKKYD PELFRMALPC LSAIAGALPP
     DYLDTRIRVT LKKQASVDPE GNFDPKPINT VNLTLPEKLE YIVSKYAEHS HDKWACDKSN
     SGWKYGVSLD ENMKTHPLIR PFKTLTEKEK EIYRWPARES LKTMLAMGWS LERTKEGEAI
     VQQRENEKLR SISQSSQGNG YSPAPLDLSN VVLSRELQGM VEVVAENYHN IWARKKKMEL
     ESKGGGSHPL LVPYDTLTAK EKSRDREKAQ ELFKFLQMNG IVVSRGLKDM DLDASSMEKR
     FAFKFLKKIL KYVDSAQEFI AHLEAIVTSG KTEKSPHDQE IKFFAKVLLP LVDQYFTNHC
     LYFLSSPIKS LSSSGYASNK EKEMVASLFC KLAALVRHRI SLFGSDSTTM VSCLHILAQT
     LDTRTVMKSG SELVKAGLRA FFENAAEDLE KTLENLKLGK FTHSRTQIKG VSQNINYTTV
     ALLPILTSIF EHIAQHQFGV DLLLGDVQVS CYRILCSLYS LGTGKNIYVE RQRPALGECL
     ASLAAAIPVA FLEPSLNCYN PLSVFNTKTA RERAILGMPD TVQEMCTEIP QLDGLMKEIN
     DLAESGARYT EMPHVIEVIL PMLCNYLSYW WEKGSENIPK SAGSCCTMVT SEQLSIILGN
     ILKIINNNLG IDEASWMKRI AVFAQPIISK ARPDLLKTHF IPTLEKLKKK AIKIVMEEEQ
     LKADSKSDTQ EAELLILDEF AVLCRDLYAF YPMLIRYVDN NRPNWLKKPD ADSDELFRMV
     AEVFILWCKS HNFKREEQNF VIQNEINNLA FLTGDSKSKM SKVSTFSGGQ DQERKKLKRR
     GDLYSIQTSL IVAALKKMLP IGLNMCTPGD QELISLAKIR YSHRDTDEEV KEHLRNNLHL
     QEKSDDPAVK WQLNLYKDIL KSEEPTDPEK TVERVQRISA AVYHLEQVEQ PLRSKKAVWH
     KLLSKQRKRA VVACFRMAPL YNLPRHRSIN LFLHGYQNYW IETEEYSFEE KLVQDLATPP
     KKDEEEVEET EKNPDPLHQI ILHFSRNALT ERSKLEDDAL YTAYSAMMAK SCQSEEEEEE
     DEEKEKTFEE KEMEKQKTLY QQARLHDRGA AEMVLQMISA SKGELSAMVI ETLKLGIAIL
     NAGNTLVQQK MLDYLKEKKD AGFFQSLSGL MQSCSVLDLN AFERQNKAEG LGMVTEEGTL
     IVRERGEKVL QNDEFTRDLF RFLQLLCEGH NNDFQNFLRT QMGNTTTVNI IISTVDYLLR
     LQESISDFYW YYSGKNVIDE SGQRNFSKAL AVTKQIFNSL TEYIQGPCIG NQQSLAHSRL
     WDAVVGFLHV FANMQMKLSK DSSQIELLKE LLDLLKDMVV MLLSLLEGNV VNGTIGKQMV
     DTLVESSSNV EMILKFFDMF LKLKDLTSSD AFKDYDPDSK GIISKKEFQK AMEGQKQYTQ
     SELEFLLSCA EADENDMFNY VDFVDRFHEP AKDIGFNVAV LLTNLSEHMP NDSRLRCLLD
     PAASVLNYFE PYLGRIEIMG GAKKIERVYF EISESSRMQW EKPQVKESKR QFIFDVVNEG
     GEQEKMELFV NFCEDTIFEM QLASQISEAD SAERPEEEEE DEPYYVMEVG DDEEEEKSLE
     SASAFSMACV AVKKNAASFL KMVTLKNLRK QYRKVRKMTI KELVKVFFSF FWVLFVGLFQ
     LFFTIVWGIF QILWSTVFGG GLVEGAKNIK VTKILGDMPD PTQFGIHDDI MEAERIEGIE
     HGIRVELVQF VKGEKGETDI SEIFGIHTKK EGGSKHGHDA GLGDVAEIVG TDTPPSLEST
     VRRKRKALVG ETNSLSLTAK IPTISFSMED GEKQDKAKEE VQFEHLGKEE TKKKKRRHGQ
     KLEKPEAVMA NFFKVVEIYQ TKMLHYLARN FYNLRFLALF VAFAINFILL FYKVTEEPLE
     ELEEDSDLWN SFEEEEEDEG MVFFVLQEST GYMAPTLRAL AIIHTIISFV CVIGYYCLKP
     KVPLVVFKRE KEIARKLEFD GLYITEQPSE DDIKGQWDRL VINTPSFPNN YWDKFVKRKV
     INKYGDLYGA ERIAELLGLD KNALDFSPVE ETEPEEASLV SWLSSIDTKY HIWKLGVVFT
     DNSFLYLAWY TTMSILGHYN NFFFAAHLLD IAMGFKTLRT ILSSVTHNGK QLVLTVGLLA
     VVVYLYTVVA FNFFRKFYNK SEDEDEPDMK CDDMMTCYLF HMYVGVRAGG GIGDEIEDPA
     GDPYEMYRIV FDITFFFFVI VILLAIIQGL IIDAFGELRD QQEQVREDME TKCFICGIGN
     DYFDTTPHGF EMHTLQEHNL ANYLFFLMYL INKDETEHTG QESFVWKMYQ ERCWDFFPAG
     DCFRKQYEDL LG
//
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