ID K7G1E9_PELSI Unreviewed; 742 AA.
AC K7G1E9;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Insulin receptor substrate 1 {ECO:0000313|Ensembl:ENSPSIP00000014110.1};
GN Name=IRS1 {ECO:0000313|Ensembl:ENSPSIP00000014110.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000014110.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000014110.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01064024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7G1E9; -.
DR STRING; 13735.ENSPSIP00000014110; -.
DR Ensembl; ENSPSIT00000014175.1; ENSPSIP00000014110.1; ENSPSIG00000012662.1.
DR eggNOG; ENOG502QUNU; Eukaryota.
DR GeneTree; ENSGT00940000161579; -.
DR HOGENOM; CLU_004902_2_1_1; -.
DR OMA; MTMQMGC; -.
DR TreeFam; TF325994; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005901; C:caveola; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005158; F:insulin receptor binding; IEA:Ensembl.
DR GO; GO:0005159; F:insulin-like growth factor receptor binding; IEA:Ensembl.
DR GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IEA:Ensembl.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
DR GO; GO:0030159; F:signaling receptor complex adaptor activity; IEA:Ensembl.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0046676; P:negative regulation of insulin secretion; IEA:Ensembl.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0032000; P:positive regulation of fatty acid beta-oxidation; IEA:Ensembl.
DR GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
DR GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Ensembl.
DR GO; GO:0046628; P:positive regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR CDD; cd01257; PH_IRS; 1.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF11; INSULIN RECEPTOR SUBSTRATE 1; 1.
DR Pfam; PF02174; IRS; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 9..111
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 155..259
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 257..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 742 AA; 80029 MW; 9346F02D2FB8EF38 CRC64;
DNNEGFFSDV RKVGYLRKPK SMHKRFFVLR AASESGPARL EYYENEKKWR HKSGAPKRSI
PLESCFNINK RADSKNKHLV ALYTKDEHFA IAADSESEQE SWYQALLQLH NRAKGHQHLH
HHRHHHHSDI SFGGGSAGVG EAGDNYGEVI PGPAFKEVWQ VILKPKGLGQ TKNLIGIYRL
CLTNKTISFV KLNSDAAAVV LQLLNIRRCG HSENFFFIEV GRSAVTGPGE FWMQVDDSVV
AQNMHETILE AMRAMSEEFR PRSKSQSSSN CSNPISVPLR SRHHVNNPPP SQVGLSRRSR
TESVTATSPA GGGGGGGTGG KPSSFRVRAS SDGEGTMSRP ASVDGSPVSP SANRTHSHRH
RGNSRLHPPL NHSRSIPMPS SRCSPSATSP VSLSSSSTSG HGSTSDCLFP RRSSASVSGS
PSDGGFISSD EYGSSPCDFR SSFRSVTPDS LGHTPPARGD EELNNYICMG CQPQQQCRFP
GTPCCPRSGG EEVTDLEKGF RKRTHSAGTS PTISHQKTPS QSSVASIEEY TEMLPSYPCG
GNRLPSYRHS AFVPTHSYPE EHLEMHHLEG SHHRTNSTPH TDDGYMPMSP GVAPVPSSGG
APKGGDYMPM SPKSVSAPQQ IINPGRGGRH VQAMVDSNGY MMMSPSGSCS PEGGSAGYGK
IWTNGAGHHP KLSVESSEGK LPCSGSDYIN MSPASGSATS TPPDCYFANS GPPGSEETSA
QDPGQPPHKP IYSYFSLPRS FK
//
