ID K7G1T9_PELSI Unreviewed; 1079 AA.
AC K7G1T9;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=PAX-interacting protein 1 {ECO:0000256|ARBA:ARBA00023858};
DE AltName: Full=PAX transactivation activation domain-interacting protein {ECO:0000256|ARBA:ARBA00030146};
GN Name=PAXIP1 {ECO:0000313|Ensembl:ENSPSIP00000014250.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000014250.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000014250.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01129098; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01129099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01129100; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01129101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01129102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01129103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01129104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7G1T9; -.
DR STRING; 13735.ENSPSIP00000014250; -.
DR Ensembl; ENSPSIT00000014317.1; ENSPSIP00000014250.1; ENSPSIG00000012656.1.
DR eggNOG; KOG2043; Eukaryota.
DR GeneTree; ENSGT00940000155757; -.
DR OMA; QNYVLRD; -.
DR TreeFam; TF329580; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0044666; C:MLL3/4 complex; IEA:Ensembl.
DR GO; GO:0060612; P:adipose tissue development; IEA:Ensembl.
DR GO; GO:0060717; P:chorion development; IEA:Ensembl.
DR GO; GO:0006338; P:chromatin remodeling; IEA:Ensembl.
DR GO; GO:0030330; P:DNA damage response, signal transduction by p53 class mediator; IEA:Ensembl.
DR GO; GO:0043542; P:endothelial cell migration; IEA:Ensembl.
DR GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IEA:Ensembl.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR GO; GO:0060261; P:positive regulation of transcription initiation by RNA polymerase II; IEA:Ensembl.
DR GO; GO:1902749; P:regulation of cell cycle G2/M phase transition; IEA:Ensembl.
DR GO; GO:0010212; P:response to ionizing radiation; IEA:Ensembl.
DR GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
DR CDD; cd17714; BRCT_PAXIP1_rpt1; 1.
DR CDD; cd17710; BRCT_PAXIP1_rpt2; 1.
DR CDD; cd17711; BRCT_PAXIP1_rpt3; 1.
DR CDD; cd17730; BRCT_PAXIP1_rpt4; 1.
DR CDD; cd17712; BRCT_PAXIP1_rpt5; 1.
DR CDD; cd18440; BRCT_PAXIP1_rpt6; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 5.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR PANTHER; PTHR23196; PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN; 1.
DR PANTHER; PTHR23196:SF37; PAX-INTERACTING PROTEIN 1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF12738; PTCB-BRCT; 2.
DR Pfam; PF16770; RTT107_BRCT_5; 1.
DR SMART; SM00292; BRCT; 6.
DR SUPFAM; SSF52113; BRCT domain; 5.
DR PROSITE; PS50172; BRCT; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 100..176
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 609..702
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 876..957
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 197..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 847..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..213
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..264
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1079 AA; 122823 MW; 33BDA00911D14584 CRC64;
MSAGGEELKV PEEMFKDVKF FAVGDIGPKV IQLLKAGKAK EVSYNALASH IIAEDGDNPE
VGESREVFDL PVVKPSWVTL SVQCGALLPY PFWVNGFSPE SCEIFFGVTA CLSQISSEDR
SVLWALVTFY GGDCQLSLNN KCTHLIVPEP KGEKYECACK RENIKIVTPD WVLDSISDKA
KKEEIFYHPR LIIYEEEEEE EEEEAENEEQ DSQNEASTDE KLSSPASSRE GSPLGDQAFS
PKSVSADKTK GELMFDDSSD SSPEKQERNL NWTPAEVPQT AAAKRRLPQG KDSGLINLCA
NVPPVPGNIL PPEIRGNIMA SVQGNQGSER PEMMATWSPA VRTLRNITNS ADIQQINRPS
NVAHILQSLS APTKSLEQQV NHSQQGHTNA VLFSQVKLTP ETHLLQQPHQ TQQQQHHPLL
HLQPQQLMQL QQQQQQQQQP QIPQQPFPQQ QSHQFSQQQQ QVHQQHQFAQ QLQFPQQQLH
PQQQLHRPQQ QLQFQQQHAL QQQLHQLQQQ QLQQQQLQQI QQQNLQQQQL QHQQQQIQQQ
QLQQQHLQRL HQQHQQQQMQ TQAPQHLTQA SQPLQHQVPA QQLQHHQQQQ QPQLQQHQLF
GHDPAIEIPE EYFLLGCVFA IADYPEQMSD KQLLATWKRI IQAHGGTVDP TLTSRCTHLL
CESQVSNMYA QAVRERKRCI TAHWLNSILK KKKMIPPHRA LHFPVAFPPG GKPCSQHIIS
VTGFVDSDRD DLKLMAYLAG AKYTGYLCRS NTVLICKDTI RPAGLKYEKA KEWRIPCVNA
QWLCDILLGN FEALRQIQHS RYTVFNLQDP LSPTQHLVLN LLDAWRVPLK VSPELLMGVR
LPLKPKQNES SLQSSSKRAR IEDIPPPTKK LSPELTPLVL FTGFEPTQVQ QYIKKLYILG
GEVAESAQKC THLIASKVTR TVKFLTAISV VKHIVTPEWL EECFKCQKFV DEQNFMLRDA
EAEVLFCFSL EESLKRAQVA PLFKGKYFYI TPGICPSLST MKAIVECAGG KVLSKQPSFR
KLMEHKQNKN LSAIILISCE NDLHLCREYF ARGIDVHNAE FVLTGVLTQT LDYESYKFT
//
