ID K7G2D4_PELSI Unreviewed; 824 AA.
AC K7G2D4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000014445.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000014445.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR EMBL; AGCU01033229; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01033230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01033231; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01033232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01033233; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01033234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01033235; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01033236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01033237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01033238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7G2D4; -.
DR Ensembl; ENSPSIT00000014513.1; ENSPSIP00000014445.1; ENSPSIG00000012780.1.
DR eggNOG; KOG2514; Eukaryota.
DR GeneTree; ENSGT00940000164482; -.
DR HOGENOM; CLU_006685_0_1_1; -.
DR OMA; KWMHRTQ; -.
DR TreeFam; TF314265; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF15; ANOCTAMIN; 1.
DR Pfam; PF16178; Anoct_dimer; 2.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 241..265
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 315..333
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 401..423
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 443..466
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 486..507
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 608..630
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 747..768
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 3..95
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 134..227
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 230..786
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 15..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 824 AA; 93261 MW; 59E2A2DA0A7A4E4C CRC64;
PADFVLVWEE KLRPPKKKRR RKLPCPEASG DRPGGRHERW QRKFLNNLRN AGLLMEKEET
LSERKSIHYL KLSAPWDVLV YYAEELCLRA PLQSSLGQAP EAAETPGPRT PVPGSTLVTL
PSPGPSALAC FLCRFLGSDS RDSYFTHTQR QRIVYEILAR TVYGKRKCAE IGIDRLLNEG
VYAAAFPLHE GPFEMPECEA SAEALNPRQV LYRFWARWGC WCRYQPLDHV REYFGEKIAI
YFAWLGFYTA WLLPAAAVGT VVFLAGLVTM GTNTPAQEIC ESGGQFLMCP LCDTCQTWNI
SEICPMAKVG YLFDHPGTVF FSVFMSFWAV TFLEHWKRKS ATLAAGGGRC GCQAPALLPE
GAGNETCPSS SQSSLQSPWQ GPSGQKCPAG NALKRHLRSS CLLEISLCVV MIFLVSVIMY
RGIVSVVMYH TGNAVLMTQA GNIANISSTL VNLALILLMS QVYTSLAEKL TRWEMHRTQT
LHEDAFTFKV FIFQFVNFYS SPFYVAFFKG RFVGYPGQYG TLLGLRNEEC GPGGCLIELA
QQLFIIMVGK QIVSNIQEFV IPCLFSDWQR QAEGLAAEGP AGQEPPRWEE DYELIDCEGL
FEEYLEMVLQ FGFITIFVAA CPLAPLFALL NNWVEIRLDA QKFVCEYRRP VAYRAQNLRH
RQHSWEPLLT LWKQTKTSCT AFLIAFTSDF LPRLLYRYEH DSQLQGFVNF TLAYSPPGYM
ATNHTLCRYK AFRDANGNYT LFYWKLLAIR LGFIIAFEHV VFFFLRLIDW LVPDIPESLE
LKIKRERYLA KQALADNQEV LLTVSHNSAS PGPMSVPAVN LQPA
//
