ID K7G2H3_PELSI Unreviewed; 532 AA.
AC K7G2H3;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=5'-nucleotidase {ECO:0000256|ARBA:ARBA00012643};
DE EC=3.1.3.5 {ECO:0000256|ARBA:ARBA00012643};
DE AltName: Full=Ecto-5'-nucleotidase {ECO:0000256|ARBA:ARBA00029793};
GN Name=NT5E {ECO:0000313|Ensembl:ENSPSIP00000014484.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000014484.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000014484.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-phosphate + H2O = a ribonucleoside +
CC phosphate; Xref=Rhea:RHEA:12484, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:18254, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043; EC=3.1.3.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000815};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004589}; Lipid-
CC anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004589}.
CC -!- SIMILARITY: Belongs to the 5'-nucleotidase family.
CC {ECO:0000256|ARBA:ARBA00006654, ECO:0000256|RuleBase:RU362119}.
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DR EMBL; AGCU01154728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01154729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01154730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01154731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01154732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01154733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01154734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01154735; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01154736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01154737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7G2H3; -.
DR STRING; 13735.ENSPSIP00000014484; -.
DR Ensembl; ENSPSIT00000014552.1; ENSPSIP00000014484.1; ENSPSIG00000012884.1.
DR eggNOG; KOG4419; Eukaryota.
DR GeneTree; ENSGT00530000063775; -.
DR HOGENOM; CLU_005854_7_1_1; -.
DR OMA; NYDCDSP; -.
DR TreeFam; TF323589; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0002953; F:5'-deoxynucleotidase activity; IEA:Ensembl.
DR GO; GO:0050484; F:GMP 5'-nucleotidase activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0050483; F:IMP 5'-nucleotidase activity; IEA:Ensembl.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0050340; F:thymidylate 5'-phosphatase activity; IEA:Ensembl.
DR GO; GO:0106411; F:XMP 5'-nucleosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0046086; P:adenosine biosynthetic process; IEA:Ensembl.
DR GO; GO:0046032; P:ADP catabolic process; IEA:Ensembl.
DR GO; GO:0006196; P:AMP catabolic process; IEA:Ensembl.
DR GO; GO:0046034; P:ATP metabolic process; IEA:Ensembl.
DR GO; GO:0055074; P:calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0140928; P:inhibition of non-skeletal tissue mineralization; IEA:Ensembl.
DR GO; GO:0007159; P:leukocyte cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR GO; GO:0010035; P:response to inorganic substance; IEA:Ensembl.
DR CDD; cd07409; MPP_CD73_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 3.90.780.10; 5'-Nucleotidase, C-terminal domain; 1.
DR InterPro; IPR008334; 5'-Nucleotdase_C.
DR InterPro; IPR036907; 5'-Nucleotdase_C_sf.
DR InterPro; IPR006146; 5'-Nucleotdase_CS.
DR InterPro; IPR006179; 5_nucleotidase/apyrase.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR PANTHER; PTHR11575:SF24; 5'-NUCLEOTIDASE; 1.
DR PANTHER; PTHR11575; 5'-NUCLEOTIDASE-RELATED; 1.
DR Pfam; PF02872; 5_nucleotid_C; 1.
DR Pfam; PF00149; Metallophos; 1.
DR PRINTS; PR01607; APYRASEFAMLY.
DR SUPFAM; SSF55816; 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR PROSITE; PS00786; 5_NUCLEOTIDASE_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00022622};
KW GPI-anchor {ECO:0000256|ARBA:ARBA00022622};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU362119};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00022622};
KW Membrane {ECO:0000256|ARBA:ARBA00022622};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362119};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 15..201
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 296..471
FT /note="5'-Nucleotidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02872"
SQ SEQUENCE 532 AA; 58568 MW; 732561136DAA319A CRC64;
RGSGKCRGGS PLDCYGGVAR RYTKVEEIRA THPNVLLLDA GDQYQGTVWF SYFKGREVVR
FMTLLGYDAM ALGNHEFDNG LDGLVDPLLK NVNFAILSAN IKASKSVASK IAGYFQPYKI
LHVGSEKIGI VGYTTVETSF LSNPGKDLIF EDEVKALQPH VDKLTTLGVN KIIALGHSGF
SVDQKIAQKV RGIDIVIGGH TNTFLYTGPP PSSEVPEGDY PFLVKSDDGR LVPVVQAYAF
GKYLGYLNVT FDDQGNVIAA SGNPIILNSS IPEDKVLREE VDRWRLQLNN FYSREIGETV
VYLNGTNQAC RFQECNMGNL ICDAMIYNNL KHRDENTWNH VSMCILNGGG IRSPIDEYNN
NGTIIMEDLL AVLPFGGTFD LIELKGSTLK EAFEHSVHRY GKGTGELLQV GGIHVVYDLS
RPPGSRVVSI EVLCTACRVP AYVPLQMDKT YKVLLPSFLQ QGGDGYYMLK EKSLSHNSGD
SDIEVVSNYI SRMGRVFPAI EGRVKFSAGN FIQGSLTLTA GLFTVPLLHF IF
//
