ID K7G3M8_PELSI Unreviewed; 2768 AA.
AC K7G3M8;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Teneurin transmembrane protein 3 {ECO:0000313|Ensembl:ENSPSIP00000014889.1};
GN Name=TENM3 {ECO:0000313|Ensembl:ENSPSIP00000014889.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000014889.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000014889.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000256|ARBA:ARBA00009385}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AGCU01134024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01134025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01134026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01134027; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01134028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01134029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01134030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01134031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01134032; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01134033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 13735.ENSPSIP00000014889; -.
DR Ensembl; ENSPSIT00000014960.1; ENSPSIP00000014889.1; ENSPSIG00000012946.1.
DR eggNOG; KOG4659; Eukaryota.
DR GeneTree; ENSGT01030000234566; -.
DR OMA; CEENSCP; -.
DR TreeFam; TF316833; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048593; P:camera-type eye morphogenesis; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR028916; Tox-GHH_dom.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR NCBIfam; TIGR01643; YD_repeat_2x; 2.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF65; TENEURIN-3; 1.
DR Pfam; PF06484; Ten_N; 1.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 8.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF101898; NHL repeat; 2.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 379..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..379
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51361"
FT DOMAIN 680..712
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 714..747
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 809..844
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 702..711
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 737..746
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 813..823
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 834..843
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2768 AA; 308192 MW; A12B2A02F64118ED CRC64;
MDVKERRPYC SLTKSRRDKE RRYTNSSAEN EECRVPTQKS YSSSETLKAF DHDSSRLLYG
NRVKDLVHRE ADEYTRQGQN FTLRQLGVCE PATRRGLAFC AEMGLPHRGY SISAGSDADT
ENEGVMSPEH AMRLWGRGVK SGRSSCLSSR SNSALTLTDT EHENKSDSEN GPPMPSSSSS
PSVIEHLHSL PPSPSLHDNQ RWLLSTNAIQ PVQDSDTDED YTTSTYLVQT GTVSVCVPDH
EQSPNNQGQS TLQPLPPSHK QHSAQHHPSI TSLNRNSLTN RRNQSPAPPA ALPAELQTTP
ESVQLQDSWV LGSNVPLESR HFLFKTGTGT TPLFSTATPG YTMASGSVYS PPTRPLPRNT
LSRSAFKFKK SSKYCSWKCT ALCAVGVSVL LAILLSYFIA MHLFGLNWQL QQTENDTFEN
GKVNSDTMPT NTVSLPSGEN GKLGGFAQEN NTIDSGELDI GRRAIQEIPP GIFWRSQLFI
DQPQFLKFNI SLQKDALIGV YGRKGLPPSH TQYDFVELLD GSRLIAREQR NLLESERAGR
QTRSISLHEA GFIQYLDSGI WHLAFYNDGK NAEQVSFNTI VIESVVECPR NCHGNGECVS
GSCHCFPGFL GPDCSRAACP VLCSGNGQYS KGRCLCYSGW KGTECDVPTT QCVDPQCGGR
GICIMGSCAC NSGYKGENCE EADCLDPACS SHGVCIHGEC HCNPGWGGSN CEILKTMCPD
QCSGHGTYLQ ESGTCTCDPN WTGADCSNEI CSVDCGSHGV CMGGTCRCEE GWTGPACNQR
ACHPRCAEHG TCKDGKCECS QGWNGEHCTI EGCPGLCNSN GRCTLDQNGW HCVCQPGWRG
AGCDVAMETL CTDSKDNEGD GLIDCMDPDC CLQSSCQNQP YCRGLPDPQD IISQSQQSPS
QQAAKSFYDR ISFLTGPDST HVIPGESPFN KSLASVIRGQ VLTADGTPLI GVNVSFLHYP
EYGYTITRQD GMFDLVANGG ASLTLVFERS PFLTQYHTVW IPWNVFYVMD TLVMKKEEND
IPSCDLSGFV RPNPVIVSSP LSTFFRISPE DSPIIPETQV LHEETTIPGT DLKLSYLSSR
AAGYKSVLKI TMTQSVIPFN LMKVHLMVAV VGRLFQKWFP ASPNLAYTFI WDKTDAYNQK
VYGLSEAVVS VGYEYESCLD LTLWEKRTAI LQGYELDASN MGGWTLDKHH VLDVQNGILY
KGNGENQFIS QQPPVVSSIM GNGRRRSISC PSCNGQADGN KLLAPVALTC GIDGSLYVGD
FNYVRRIFPS GNVTSVLELS SNPAHRYYLA TDPVTGDLYV SDTNTRRIYR PKSLTGAKDL
TKNADVVAGT GEQCLPFDEA RCGDGGKAVE ATLMSPKGMA IDKNGLIYFV DGTMIRKVDQ
NGIISTLLGS NDLTSARPLT CDTSMHISQV RLEWPTDLAI NPMDNSIYVL DNNVVLQITE
NRQVRIAAGR PMHCQVPGVE YSVGKHAVQT TLESATAIAV SYSGVLYITE TDEKKINRIR
QVTTDGEISL VAGIPSECDC KNDVNCDCYQ SGDGYAKDAK LNAPSSLAVS PDGTLYIADL
GNIRIRAVSK NKPLLNSVNF YEVASPTDQE LYIFDVNGTH QYTMSLVTGD YLYNFSYSND
NDITAVTDSN GNTLRIRRDP NRMPVRVVSP DNQVIWLTIG TNGCLKSMTA QGQELVLFTY
HGNSGLLATK SDETGWTTFF DYDSEGRLTN VTFPTGVVTN LHGEMERAIT VDIESSSREE
DVSITSNLSS IDSFYTMVQD QLRNSYQIGY DGSLRIIYAS GMDSHYQTEP HVLAGTANPT
VAKRNMTLPG ENGQNLVEWR FRKEQAQGKV NVFGRKLRVN GRNLLSVDFD RTTKTEKIYD
DHRKFLLRIA YDTSGHPTLW LPSSKLMAVN VTYSSTGQIG SIQRGTTSEK VDYDGQGRIV
SKVFADGKTW SYTYLEKSMV LLLHSQRQYI FEYDLLDRLS AITMPSVARH TMQTIRSIGY
YRNIYNPPES NASVIMDYNE EGQLLQTAFL GTSRRVLFKY RRQTKLSEIL YDSTRVSFTY
DETAGVLKTV NLQSDGFICT IRYRQIGPLI DRQIFRFSED GMVNARFDYS YDNSFRVTSM
QGVINETPLP IDLYQFDDIS GKVEQFGKFG VIYYDINQII STAVMTYTKH FDAHGRIKEI
QYEIFRSLMY WITIQYDNMG RVTKREIKIG PFANTTKYAY EYDVDGQLQT VYLNEKIMWR
YNYDLNGNLH LLNPSNSARL TPLRYDLRDR ITRLGDVQYR LDEDGFLRQR GTEIFEYSSK
GLLTRVYSKG SGWTVIYRYD GLGRRVSSKT SLGQHLQFFY ADLTYPTRIT HVYNHSSSEI
TSLYYDLQGH LFAMEISSGD EFYIASDNTG TPLAVFSSNG LMLKQIQYTA YGEIYFDSNL
DFQLVIGFHG GLYDPLTKLV HFGERDYDIL AGRWTTPDIE IWKRIGKDPA PFNLYMFRNN
NPASKIHDVK DYITDVNSWL VTFGFHLHNA IPGFPVPKFD LTEPSYELVK SQQWDDIPPI
SGVQQQVARQ AKAFLSLGKM AEVQISRPKS SGEKSWLWFA TVKSLIGKGV MLAVNQGKVL
TNVLNIANED CIKVAAVLNS AYYLENLHFT IEGKDTHYFI KTTSPESDLG TLRLTSGRKA
LENGINVTVS QSTTVVNGRT RRFADVEMQY GALALHVRYG MTLDEEKARI LEQARQRALS
NAWAREQQRV RDGEEGARLW TEGEKRQLLS AGKDGAFPSG WLIRQQLPFL SPKPGQLHQS
LLEGTVTK
//
