ID K7G3U7_PELSI Unreviewed; 724 AA.
AC K7G3U7;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Holocarboxylase synthetase {ECO:0000313|Ensembl:ENSPSIP00000014958.1};
GN Name=HLCS {ECO:0000313|Ensembl:ENSPSIP00000014958.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000014958.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000014958.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the biotin--protein ligase family.
CC {ECO:0000256|ARBA:ARBA00009934}.
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DR EMBL; AGCU01106090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01106091; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01106092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01106093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01106094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01106095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01106096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01106097; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01106098; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01106099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7G3U7; -.
DR Ensembl; ENSPSIT00000015029.1; ENSPSIP00000014958.1; ENSPSIG00000013364.1.
DR GeneTree; ENSGT00390000002960; -.
DR HOGENOM; CLU_006150_2_0_1; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0004077; F:biotin-[acetyl-CoA-carboxylase] ligase activity; IEA:InterPro.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR CDD; cd16442; BPL; 1.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR004408; Biotin_CoA_COase_ligase.
DR InterPro; IPR003142; BPL_C.
DR InterPro; IPR004143; BPL_LPL_catalytic.
DR NCBIfam; TIGR00121; birA_ligase; 1.
DR PANTHER; PTHR12835; BIOTIN PROTEIN LIGASE; 1.
DR PANTHER; PTHR12835:SF5; BIOTIN--PROTEIN LIGASE; 1.
DR Pfam; PF02237; BPL_C; 1.
DR Pfam; PF03099; BPL_LplA_LipB; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 452..650
FT /note="BPL/LPL catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51733"
FT REGION 53..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 724 AA; 80911 MW; 1325DC6807C083E2 CRC64;
MVPQKIVSVH LQESALKALE QVAASTEEKK NTDCAQIGEL IPALPFEAIT KQGSVSIDST
GGGDQELREE REKSRSEKRS EPHDELDSLS ERETSMGKHH HLHLSSCHEC FELENSTIES
VRFASSENIP DLPDDCSASV DEVIDGGLAR ELKRVNLTGK PPNVLIYVGS DPMKIKFEKI
KSVIKECIDT NSYTIYQLVE EQVLKAPWLD NSLLLVIATE EPISEENHKQ FLTYLSKGGK
ILGLSALFTF GTIQIRSKSE LKKTIQELVF YKADNSEIKL NFLTSGNVFE EDVKGNFRTV
KSLSHLNNTD EDMIIVQLPY GDCGGEAILC QIYLEMDISS TTQTQEDFNL LKMNNVKRYE
VLKEILTLLG LSCELSEVPS LTPVYLLSPN EDIRISFLKW LGKKKDAQGL IKSSKMTLKF
VSSYKPEMEI TPSLIPVVTD VGGFSSEHFS LQMYQQNLLT KKLGKIVLLA EVTSTTMNLL
DGLMFDLPQE MDLIAIAVQQ TQGKGRGGNV WLSPVGCALS TLHISIPLCS QLGQRIPFIQ
HLVSLAVVES VRSIPGYQDI DLRVKWPNDI YYSDHMKLGG VLVNSTLMGN TFHILIGCGF
NVNNSSPTIC INDLIMEYNK KSMTKLRPLT TDYLIARSVT VLERLIDMFQ EKGPNGVLPL
YYKYWIHAGK QVHLWSEEGP VAWIVGIDDC GFLQVHEEGK GVESVHPDGN SFDMLKNLII
SKQQ
//
