ID K7G5G1_PELSI Unreviewed; 1369 AA.
AC K7G5G1;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Rho guanine nucleotide exchange factor 28 {ECO:0000313|Ensembl:ENSPSIP00000015522.1};
GN Name=ARHGEF28 {ECO:0000313|Ensembl:ENSPSIP00000015522.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000015522.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000015522.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AGCU01094533; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01094534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01094535; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01094536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01094537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01094538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01094539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01094540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01094541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01094542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPSIT00000015595.1; ENSPSIP00000015522.1; ENSPSIG00000013632.1.
DR GeneTree; ENSGT00940000155831; -.
DR HOGENOM; CLU_002466_2_1_1; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20876; C1_p190RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR13944; AGAP007712-PA; 1.
DR PANTHER; PTHR13944:SF22; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 28; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 341..388
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 538..734
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 776..878
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 430..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 975..1022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1107..1140
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1170..1204
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 430..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..1012
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1369 AA; 156278 MW; 482CC6C437E05580 CRC64;
MDSDSDSPFN YSWPSLPKMR IRRRGTKQEL RHSALDVLKK SPNPPAFFAA ATHTAMLNGS
DEVYANCMVV DQGRDLDVNY INVDSITTEI STDHTCSTLT PNSSSSVSLK KSSQYVYAEN
EDNQMAMNNI DNIGSQLFTS PSNVYAAGSY LPLKSRGFNT ERSQLYADLK KRSSSLDDLE
VDSGSEGISD RSHIRYPSLN SSVTLASSRD ELDSSETSTD LDYSIHRMDS NNLLSKESLL
SGIRSRSYSC SSPKVLLGKS RFSRDFTVCD SNEEQRAYSL PEQSREKRIK EEEWDKYIIP
TKSESEKYKV SRTFSFLMNR MTSTRNKCKT KNKEAKDKLN RHQFITGNFS GNILCMACDK
ALLGKESLQC SYCNVIVHKN CKDCAPACTK KFQERYHVKT GSQAVLTNSS FRDLPQPIFS
SIHPSSSMPT GLSAVKKEVS QQPHALSRSV PCASFERRSM PSADQDTDSS SWRANSQPEM
LLQSIGTLPS MDSFVMEDDV DASLWTDLST EAQEFEAESW SLVVDPAFCS KQEKDVIKRQ
DVIFELMQTE VHHIHTLFIM SEIFRKGMKE ELQLDHSTVD RIFPCLDELL EIHRQFFCTL
KERRQESCEG GNERNFLINR IGDILVQQFS EESANKMKKI YGEFCSHQKE AVNIFKELQQ
NKKFQNFIKL RNSNLLARRR GIPECILLVT QRITKYPVLV ERILQYSKEG TEEHKDLCSA
LCLIKDMIAA VDLKVNDYEK SQKLLEILNK IENKTFTKLK NGHVFRKQDL KKKERTLLHE
GLVYWKTATG RFKDSLALLL TDVLLFLQEK DQKYIFATVD QKPSVISLQK LIVREVANEE
RGMFLISASS AGPEMYEIHT NSKEERNTWM RQIQDAVESC PEEEGKISES DEDRQIAEAK
AAKIQKYQES LSNQDQQICS YLEDKLHIYA ELGDMSGFED VHVEPHLLIK PDSGEMPQAS
SLLAAALKEA ESLHVAVTSS QANDTNRSSE ESPGEPSLRL SPSTNEIVDS STDSTEIKGD
EESFDFNPRI CHAVNEVADS VLEEKVEHIN FSGSTSTEVV QAIQNLTRLL YSIQAAVTIQ
DSHVEIHKTL LQEHERTSCG HSSRGNLLLD QEKYRNLEKQ REELANIQKL QQQFHQEQQR
WARECDQQQR EQEIRESQLQ ERERDCMCQE ENLHRNQGEL EHQLQEFQQD LERLKEGQRM
VEIERDKVKM QQKILWHWQH SRQSSLPATL PSSVSNEIMG RNQMESFCGE NSFFINEALV
QMSLNSLNRS NPTLVYQDGV YGINTASSEI SRTSENPPAV THELWKSTAP CHQVSSCKSN
KDSCNNDLTL SQIQCPRTHS LNPGCIQVQP LVEVRFFLIH KYCMYIVVV
//