ID K7G629_PELSI Unreviewed; 730 AA.
AC K7G629;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=X-ray repair cross-complementing protein 5 {ECO:0000256|PIRNR:PIRNR016570};
DE EC=3.6.4.- {ECO:0000256|PIRNR:PIRNR016570};
GN Name=XRCC5 {ECO:0000313|Ensembl:ENSPSIP00000015740.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000015740.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000015740.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Single-stranded DNA-dependent ATP-dependent helicase.
CC {ECO:0000256|PIRNR:PIRNR016570}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR016570}.
CC -!- SIMILARITY: Belongs to the ku80 family. {ECO:0000256|ARBA:ARBA00007726,
CC ECO:0000256|PIRNR:PIRNR016570}.
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DR EMBL; AGCU01098218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01098219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01098220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01098221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01098222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01098223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7G629; -.
DR Ensembl; ENSPSIT00000015814.1; ENSPSIP00000015740.1; ENSPSIG00000013929.1.
DR GeneTree; ENSGT00940000153239; -.
DR HOGENOM; CLU_010975_2_1_1; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd00873; KU80; 1.
DR CDD; cd01458; vWA_ku; 1.
DR Gene3D; 1.10.1600.10; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 1.25.40.240; Ku, C-terminal domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR024193; Ku80.
DR InterPro; IPR005160; Ku_C.
DR InterPro; IPR036494; Ku_C_sf.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR014893; Ku_PK_bind.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR PANTHER; PTHR12604:SF4; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03730; Ku_C; 1.
DR Pfam; PF03731; Ku_N; 1.
DR Pfam; PF08785; Ku_PK_bind; 1.
DR PIRSF; PIRSF016570; Ku80; 1.
DR SMART; SM00559; Ku78; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF101420; C-terminal domain of Ku80; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR016570};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR016570};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172,
KW ECO:0000256|PIRNR:PIRNR016570};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|PIRNR:PIRNR016570};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR016570};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PIRNR:PIRNR016570};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR016570};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR016570};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR016570};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..730
FT /note="X-ray repair cross-complementing protein 5"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003902502"
FT DOMAIN 15..161
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 542..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..572
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..708
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 730 AA; 82948 MW; 993959682E2B0FAB CRC64;
VSFMLIKAAI VLCMDVGFAM SNSAPGEESP FEQAKKVMTK FVQRQVFAES KDEVSVVLFG
TDDTQNTLAS GDQYQNITVQ RHLMLPDFDL LEEIQNAIQP GSEQADFLDA LVVCMDLLQK
ETVGKKYEKR HIEVFTDLSS PFSEDQLEII IANLKKTGIS LQFFLPFPVD DEDGSGDLGD
GRHSEMYRNS FPRKGLTEQQ KEGICMVRKL MFALEEGGLD EIYTFRESLE RLSMFKKIER
RPMAWPCQLT IGSNLSIRIV AYKSLTEEKV KKSWTLVDAQ TLKKEDLQKE TVYCLNDDDE
TEVQKDDLVQ GFRYGSDIVP FSKVDEEQMK YKTEGKCFSV LGFSRASQIQ RHHYMGSQVL
KVFAAKDDEA AAVALSALIH ALDELDVVAI VRYAYDRRSN PQVGVAFPYI KDAYECLIYV
QLPYMEDLRQ YMFSSLKNNK KYTPTVDQLS AVDSLIDSMS LVYEDEDGET TEDLFKTSKI
PNPQFQRLYQ CLQHKAFHPD KPLPPIEQHL LEMLEAPQEV RETSQAPLEK IKALFPLKDA
GKKKEQKTAQ DVFKNNNEDE PSAKKAREEN EEGGFSISNL AEGNVTSVGS INPAENFCVL
VRQKNANFKE VSRQLANRIE QFLETKGLQY YMKSINCIRV FREEAIKLSE VQCFNDFLRD
LKEKVEDKTL ADFWEILIQD GISLITKDEA EGSSVTSEEA KKFLAPKEKP TETPSVAGEG
GDVDDLLDMM
//
