ID K7G6Q5_PELSI Unreviewed; 716 AA.
AC K7G6Q5;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Fermitin family member 2 {ECO:0000313|Ensembl:ENSPSIP00000015966.1};
GN Name=FERMT2 {ECO:0000313|Ensembl:ENSPSIP00000015966.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000015966.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000015966.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the kindlin family.
CC {ECO:0000256|ARBA:ARBA00008052}.
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DR EMBL; AGCU01041144; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01041145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01041146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01041147; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01041148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01041149; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01041150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01041151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7G6Q5; -.
DR STRING; 13735.ENSPSIP00000015966; -.
DR Ensembl; ENSPSIT00000016041.1; ENSPSIP00000015966.1; ENSPSIG00000014143.1.
DR eggNOG; KOG3727; Eukaryota.
DR GeneTree; ENSGT00390000013444; -.
DR OMA; PEHGIHY; -.
DR TreeFam; TF314677; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005912; C:adherens junction; IEA:Ensembl.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001725; C:stress fiber; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0046332; F:SMAD binding; IEA:Ensembl.
DR GO; GO:0034713; F:type I transforming growth factor beta receptor binding; IEA:Ensembl.
DR GO; GO:0034334; P:adherens junction maintenance; IEA:Ensembl.
DR GO; GO:0048041; P:focal adhesion assembly; IEA:Ensembl.
DR GO; GO:0033622; P:integrin activation; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0060173; P:limb development; IEA:Ensembl.
DR GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
DR GO; GO:0043116; P:negative regulation of vascular permeability; IEA:Ensembl.
DR GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Ensembl.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0051894; P:positive regulation of focal adhesion assembly; IEA:Ensembl.
DR GO; GO:0033625; P:positive regulation of integrin activation; IEA:Ensembl.
DR GO; GO:1902462; P:positive regulation of mesenchymal stem cell proliferation; IEA:Ensembl.
DR GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:1900182; P:positive regulation of protein localization to nucleus; IEA:Ensembl.
DR GO; GO:0051496; P:positive regulation of stress fiber assembly; IEA:Ensembl.
DR GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Ensembl.
DR GO; GO:1903691; P:positive regulation of wound healing, spreading of epidermal cells; IEA:Ensembl.
DR GO; GO:1902414; P:protein localization to cell junction; IEA:Ensembl.
DR GO; GO:0072657; P:protein localization to membrane; IEA:Ensembl.
DR GO; GO:0022604; P:regulation of cell morphogenesis; IEA:Ensembl.
DR GO; GO:0034446; P:substrate adhesion-dependent cell spreading; IEA:Ensembl.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl.
DR CDD; cd13205; FERM_C_fermitin; 1.
DR CDD; cd17181; FERM_F0_KIND2; 1.
DR CDD; cd17184; FERM_F1_KIND2; 1.
DR CDD; cd01237; PH_fermitin; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR037843; Kindlin/fermitin.
DR InterPro; IPR040790; Kindlin_2_N.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037837; PH_Kindlin/fermitin.
DR PANTHER; PTHR16160; FERMITIN 2-RELATED; 1.
DR PANTHER; PTHR16160:SF11; FERMITIN FAMILY HOMOLOG 2; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF18124; Kindlin_2_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 409..505
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 170..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 716 AA; 82027 MW; 9239FEA73B56815F CRC64;
MLILPPPYWR LPPSTRRFLA ARTTGEEGTM ALDGIRMPDG CYADGTWELN VHVTDLNRDV
TLRVTGEVHI GGVMLKLVEK LDVKKDWSDH ALWWEKKRTW LLKTHWTLDK YGIQADARLQ
FTPQHKLLRL QLPNMKYVKV KVNFSDRVFK AVSDICKTFN IRHPEELSLL RKPRDPTKKK
KKKIDDQSED EALELEGPLI TPGSGSIYSS PGLYSKTMTP TYDSHDGSPL SPTSAWFGDS
ALSEGNPGVL AVSQPITSPE ILAKMYKPQA LLDKAKINQG WLDSSRSLME QDVKENEALL
LRFKYYNFFD LNPKYDAIRI NQLYEQSKWA IVLEEIECTE EEMMMFAALQ YHVNKLSIMS
SENHLNNSDK EVDEVDAALS DLEITLEGGK TSTILGDITS IPELADYIKV FKPKKLTLKG
YKQYWCTFKD TSISCYKSKD ESNGTPAHQM NLRGCEVTPD VNISGQKFNI KLLIPVADGM
NEIWLRCDNE KQYAHWMAAC RLASKGKTMA DSSYNLEVQN ILSFLKMQHL NPDPQLIPEQ
VTADINPECL VSPRYLKKYK NKQPGYIRDL ITARILEAHQ NVAQMSLIEA KMRFIQAWQS
LPEFGITHFI ARFQGGKKEE LIGIAYNRLI RMDASTGDAI KTWRFSNMKQ WNVNWEIKMV
TVEFADDVRV SFICTEVDCK VVHEFIGGYI FLSTRAKDQN ESLDEEMFYK LTSGWV
//