ID K7G7J4_PELSI Unreviewed; 775 AA.
AC K7G7J4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=ENAH actin regulator {ECO:0000313|Ensembl:ENSPSIP00000016255.1};
GN Name=ENAH {ECO:0000313|Ensembl:ENSPSIP00000016255.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000016255.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000016255.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the Ena/VASP family.
CC {ECO:0000256|ARBA:ARBA00009785}.
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DR EMBL; AGCU01051859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01051860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01051861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01051862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01051863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01051864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01051865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01051866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01051867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01051868; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006118095.1; XM_006118033.2.
DR AlphaFoldDB; K7G7J4; -.
DR STRING; 13735.ENSPSIP00000016255; -.
DR Ensembl; ENSPSIT00000016331.1; ENSPSIP00000016255.1; ENSPSIG00000014372.1.
DR GeneID; 102454611; -.
DR CTD; 55740; -.
DR eggNOG; KOG4590; Eukaryota.
DR GeneTree; ENSGT00940000157376; -.
DR HOGENOM; CLU_017790_1_0_1; -.
DR OMA; APMPPNM; -.
DR OrthoDB; 2884005at2759; -.
DR TreeFam; TF321411; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0050699; F:WW domain binding; IEA:Ensembl.
DR CDD; cd01207; EVH1_Ena_VASP-like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR038023; VASP_sf.
DR InterPro; IPR014885; VASP_tetra.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR11202:SF1; PROTEIN ENABLED HOMOLOG; 1.
DR PANTHER; PTHR11202; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF08776; VASP_tetra; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF118370; Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain; 1.
DR PROSITE; PS50229; WH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 1..111
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT REGION 127..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..389
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..458
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..587
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..684
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 685..733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 775 AA; 84214 MW; 3BACB8DF398C1BA5 CRC64;
MSEQSICQAR AAVMVYDDTN KKWVPAGGST GFSRVHIYHH TGNNTFRVVG RKIQDHQVVI
NCAIPKGLKY NQATQTFHQW RDARQVYGLN FGSKEDANVF ASAMMHALEV LNSQEAVFYL
GPTLPRQNSQ LPPQVQNGPS QEELEIQRRQ LQEQQRQKEL ERERLDRERM ERERLERDRL
ERERLERERL EQEQLERERQ ERERQERLER ERQERERQDR ERLERLERER QERERQEQLE
REQLEWERER RISNAASSFD NSLYSTPLPE YSSCQPPSAP PPSYAKAISA AGSDSAPDYA
VVTSAQATST PPTPPLRHSA SRFATSLGSA FHPVLPHYAT VPRPLNKNSR PPSPVNAPAS
LPPNTKSIVW SAPSFAPLPP SPPVMISSPP GKAAGPKPVL PISASSSVSQ MHQSPPPPNG
LPESVTYPVP SPSTSGPTPP PPPPPPLPSF PPVSLSGPQA SPSPSSPNAS TPSSKPSVLP
SPSAATPASV ENSLNSVLGD SSASEPVLQA AFQLIEPPTQ QGVIQGPPAP PPPPPLPPGP
AQSSTAIPPP PGPPPPLPPS GPPPPPPLPS QVPPPVPPPP PAPPLPASGF SMGSMSEDSR
PLTGLAAALA GAKLRKVSRN EESSSPCGGA LSKADSVRGN GPLPLGGSGL MEEMSALLAR
RRRIAEKGST EPEQKEDKPE ESEPSTSKPS STSTPELTRK PWERTNTVNG SKSPVISRPK
STPSGQPSAN GVQSEGLDYD RLKQDILDEM RKELTKLKEE LIDAIRQELN KSNTA
//
