ID K7G814_PELSI Unreviewed; 537 AA.
AC K7G814;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=NTR domain-containing protein {ECO:0000259|PROSITE:PS50189};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000016425.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000016425.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; AGCU01098611; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01098612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01098613; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01098614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01098615; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01098616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7G814; -.
DR STRING; 13735.ENSPSIP00000016425; -.
DR Ensembl; ENSPSIT00000016501.1; ENSPSIP00000016425.1; ENSPSIG00000014645.1.
DR eggNOG; KOG1366; Eukaryota.
DR GeneTree; ENSGT00940000154063; -.
DR HOGENOM; CLU_001634_6_2_1; -.
DR OMA; EMACEST; -.
DR TreeFam; TF352568; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.210.20; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR048848; C3_CUB2.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11412:SF81; COMPLEMENT C3; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF21308; C3_CUB2; 1.
DR Pfam; PF01759; NTR; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM00643; C345C; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 391..535
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
SQ SEQUENCE 537 AA; 61168 MW; A0E16463303F33D8 CRC64;
MAKSMMGGYQ GAEPEASLTA FVLVALLESK DICNDHVTSL NSSITKAGEY LDRKYSSLTR
PYTVAIASYA LALVGKVDSE EVLMSTSRER NRWEDTNAHT FSIEATSYAL LALLHMKKYE
EAGPLVRWLA EQKFYEGGYG STQAIIMVFQ ALAQYQVDAP LRKELNLDVS ILLPGRTKSI
TYRIEHENAM VTRSTETRLN KDFVVRARGI GQGTLTVVTV YNAKIPEDTS QCKKFDLKVS
VSEAEGARKP EGALRSVYIK ICVRYLGEVN ATMSILDVTM LTGFRPDMED LNRLSKGVDR
YIAQYENGKS SEDRNTLIIY LDKVSHLEEE CLQFKVHQFF EVGLIQPGAV KVYEYYSLDD
RCITFYRLPQ ESGLLNRICH GDICRCAEEN CFLQHKTSES LTLHKRIEMA CESTVDYVYK
TKLVGTGQSN NYDNYMMDIL QVIKTGTDEN PLRTVRPFIS HVKCRDSLKL ELNKDYLIWG
HRNDLWALKT NVSYLVSKDT WLEEWPSEED CQEKKFQSQC QDLDFFSQAL TMDGCLT
//
