ID K7G883_PELSI Unreviewed; 657 AA.
AC K7G883;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Dynein cytoplasmic 1 intermediate chain 2 {ECO:0000313|Ensembl:ENSPSIP00000016494.1};
GN Name=DYNC1I2 {ECO:0000313|Ensembl:ENSPSIP00000016494.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000016494.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000016494.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the dynein intermediate chain family.
CC {ECO:0000256|ARBA:ARBA00011059}.
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DR EMBL; AGCU01201162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01201163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01201164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01201165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7G883; -.
DR STRING; 13735.ENSPSIP00000016494; -.
DR Ensembl; ENSPSIT00000016570.1; ENSPSIP00000016494.1; ENSPSIG00000014619.1.
DR eggNOG; KOG1587; Eukaryota.
DR GeneTree; ENSGT00940000155442; -.
DR OMA; MHDRPEY; -.
DR TreeFam; TF300553; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IEA:InterPro.
DR GO; GO:0005874; C:microtubule; IEA:Ensembl.
DR GO; GO:0031982; C:vesicle; IEA:Ensembl.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR025956; DYNC1I1/DYNC1I2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR12442:SF37; CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 2; 1.
DR PANTHER; PTHR12442; DYNEIN INTERMEDIATE CHAIN; 1.
DR Pfam; PF11540; Dynein_IC2; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT REGION 21..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 657 AA; 73671 MW; 455FF86227BC6B5A CRC64;
MSDKSELKAE LERKKQRLAQ IREEKKRKEE ERKKKETDQK KEVLPVQDES DLEKKRREAE
ALLQSMGLTP DSPIEFGHLL AENSSYNMSL LIFIFIHYLV PPPMSPSSKS VSTPSEAGSQ
DSGDGAVGPR TLHWDTDPSV LQLHSDSDLG RGSIKLGMGK ITQVDFPPRE IVTYTKETQT
PVVTQPKEDD EDEDDVVVPK PSVEPEEEKT LKNDKEEFSP SAAPHELTEE EKQQILHSEE
FLSFFDHSTR IVERALSEQI NIFFDYSGRD LEDKEGEIQA GAKLSLNRQF FDERWSKHRV
VSCLDWSSQY PELLVASYNN NEDAPHEPDG VALVWNMKYK KTTPEYVFHC QSAVMSATFA
KFHPNLVVGG TYSGQIVLWD NRSNKRTPVQ RTPLSAAAHT HPVYCVNVVG TQNAHNLISI
STDGKICSWS LDMLSQPQDS MELVHKQSKA VAVTCMSFPV GDVNNFVVGS EEGSVYTACR
HGSKAGISEM FEGHQGPITG IHCHAAVGPV DFSHLFVTSS FDWTVKLWTT KNNKPLYSFE
DNSDYVYDVM WSPTHPALFA CVDGMGRLDL WNLNNDTEVP TASITVEGNP ALNRVRWTHS
GREIAVGDSE GQIVIYDVGE QIAVPRNDEW TRFGRTLAEI NANRADAEEE AATRIPA
//
