ID K7G8V3_PELSI Unreviewed; 760 AA.
AC K7G8V3;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Rho GTPase-activating protein 26 {ECO:0000256|ARBA:ARBA00020525};
DE AltName: Full=Rho-type GTPase-activating protein 26 {ECO:0000256|ARBA:ARBA00032211};
GN Name=ARHGAP26 {ECO:0000313|Ensembl:ENSPSIP00000016714.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000016714.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000016714.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGCU01122928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01122929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01122930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01122931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01122932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01122933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01122934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01122935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01122936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01122937; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006128605.1; XM_006128543.2.
DR AlphaFoldDB; K7G8V3; -.
DR STRING; 13735.ENSPSIP00000016714; -.
DR Ensembl; ENSPSIT00000016790.1; ENSPSIP00000016714.1; ENSPSIG00000014722.1.
DR GeneID; 102453521; -.
DR KEGG; pss:102453521; -.
DR CTD; 23092; -.
DR eggNOG; KOG1451; Eukaryota.
DR GeneTree; ENSGT00940000157254; -.
DR HOGENOM; CLU_011532_2_0_1; -.
DR OMA; YALITSQ; -.
DR OrthoDB; 5395569at2759; -.
DR TreeFam; TF316851; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01249; BAR-PH_GRAF_family; 1.
DR CDD; cd07636; BAR_GRAF; 1.
DR CDD; cd04374; RhoGAP_Graf; 1.
DR CDD; cd12064; SH3_GRAF; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR035483; GRAF_BAR.
DR InterPro; IPR047234; GRAF_fam.
DR InterPro; IPR035481; GRAF_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047225; PH_GRAF.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR PANTHER; PTHR12552:SF4; RHO GTPASE-ACTIVATING PROTEIN 26; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 265..369
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 383..568
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 702..760
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 584..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 635..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 684..701
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 760 AA; 86541 MW; 85663DD34EA298FC CRC64;
MGLPALEFSD CCLDSPQFRE RLKSHEAELD KTNKFIKELI KDGKTLVAAL KNLSSAKRKF
ADSLNEFKFR CIGDAETDDE ICIAKSLQEF ATVLRNLEDE RMRMIENAGE VLITPLEKFR
KEQIGAAKDA KKKYDKETEK YCGVLEKHLN LSSKKKESQL QEADSQVDLV RQHFYEVSLE
YVFKVQEVQE RKMFEFVEPL LAFLQGLFTF YHHGYELAKD FSDFKTELTI SIQNTRNRFE
GTRSEVESLM KKMKENPHEH KNISPYTMEG YLYVQEKRHF GTSWVKHYCT YQRESKRITM
VPFDQKSGGK GGEDEAVTLK SCTRRKTDSI EKRFCFDVEA VDRPGVITMQ ALSEEDRRLW
MEAMDGREPV YNSNKDNQSE GTAQLDNIGF SIIRKCIHAV ETRGINEQGL YRIVGVNSRV
QKLLSILMDP KTASETETEI CAEWEIKTIT SALKNYLRML PGPLMMYQFQ RSFIKAAKLE
NQESRISEIH NLVHRLPEKN RQMLQMLMNH LANVAANHKQ NLMTVANLGV VFGPTLLRPQ
EETVAAIMDI KFQNIVIEIL IENHEKIFNT VPETLPPNSQ LLLSRKKSTD SKPPSCSERP
LTLFHTGQPN EKQETRNSII NSSLESVLSS NINSFPHSNS TLQPNLNSSD PDLEVIKPSR
PTSLTQNPSP TSPLSPSWPL FSAPSSPMPT SSTSSDSSPI SSPFRKARAL YACKAEHDSE
LSFTAGTIFD NVHASQEPGW LEGTLNGKTG LIPENYVEFL
//