ID K7G9I1_PELSI Unreviewed; 823 AA.
AC K7G9I1;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=IQ motif and Sec7 domain ArfGEF 1 {ECO:0000313|Ensembl:ENSPSIP00000016942.1};
GN Name=IQSEC1 {ECO:0000313|Ensembl:ENSPSIP00000016942.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000016942.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000016942.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BRAG family.
CC {ECO:0000256|ARBA:ARBA00006248}.
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DR EMBL; AGCU01105200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01105201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01105202; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01105203; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01105204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7G9I1; -.
DR STRING; 13735.ENSPSIP00000016942; -.
DR Ensembl; ENSPSIT00000017020.1; ENSPSIP00000016942.1; ENSPSIG00000015086.1.
DR eggNOG; KOG0931; Eukaryota.
DR GeneTree; ENSGT00940000156915; -.
DR HOGENOM; CLU_004328_0_1_1; -.
DR OMA; AGHSAHH; -.
DR TreeFam; TF323811; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13318; PH_IQSEC; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR033742; IQSEC_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF327; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF16453; IQ_SEC7_PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 400..593
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 196..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..329
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 823 AA; 94064 MW; 6CF69A6DC7794740 CRC64;
MLERKYGGRL ITRHAARTIQ TAFRQYQMNK NFERLRSSMS ENRMSRRIVL SNMRMQFSFE
GPEKVHSSYF EGKQVSLTND GSKIGALVQS ECGDLAESTT MKSPAASTDF ADAITELEDA
FSRQVKSLAE SIDDALNCRS LHSDEVQTPD QIRSREMERD SCSQIKPAIH NVDHRKLDEM
TASYSDVTLY IDEEELSPPL PLSQSVDRPS STESDLRLRS MNSSQEYWSM THKDDKIDTD
TSCRSTPSLE CQEQRMRMDH LPLLTIEPPS DSSVDLSDRS ERGSLKRQNA YDRGITSQQG
SPKHIPHGIP TKIISREEQE ARHKPRPIDS HLAINGTANR QSKSESDYSD GDNDSINSTS
NSNDTINCSS ESSSRDSLRE QTLSKQTYHK ETRNSWDSPA FSNDVIRKRH YRIGLNLFNK
KPEKGVQYLI ERGFVPDTPV GVAHFLLQRK GLSRQMIGEF LGNRQKQFNR DVLDCVVDEM
DFSAMELDEA LRKFQAHIRV QGEAQKVERL IEAFSQRYCI CNPGVVRQFR NPDTIFILAF
AIILLNTDMY SPNVKPERKM KLEDFVKNLR GVDDGEDIPR EMLIGIYERI RKRELKTNED
HVSQVQKVEK LIVGKKPIGS LHHGLGCVLS LPHRRLVCYC RLFEVPDPNK PQKLGLHQRE
IFLFNDLLVV TKIFQKKKNS VTYSFRQSFS LYGMQVLLFE NQYYPNGIRL TSAVPGADIK
VLINFNAPNP QDRKKFTDDL RESIAEVQEM EKHRIESELE KQKGVVRPSI SQCSSLKKES
GNGTLNRACL DDSYATGEGL KRSALSSSLR DLSEADLERK RKH
//
