ID K7GA05_PELSI Unreviewed; 474 AA.
AC K7GA05;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Target of myb1 like 1 membrane trafficking protein {ECO:0000313|Ensembl:ENSPSIP00000017116.1};
GN Name=TOM1L1 {ECO:0000313|Ensembl:ENSPSIP00000017116.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000017116.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000017116.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TOM1 family. {ECO:0000256|ARBA:ARBA00007708,
CC ECO:0000256|PIRNR:PIRNR036948}.
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DR EMBL; AGCU01100616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01100617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01100618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01100619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01100620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006125198.1; XM_006125136.2.
DR AlphaFoldDB; K7GA05; -.
DR STRING; 13735.ENSPSIP00000017116; -.
DR Ensembl; ENSPSIT00000017194.1; ENSPSIP00000017116.1; ENSPSIG00000015190.1.
DR GeneID; 102456640; -.
DR KEGG; pss:102456640; -.
DR CTD; 10040; -.
DR eggNOG; KOG1087; Eukaryota.
DR GeneTree; ENSGT00940000160240; -.
DR HOGENOM; CLU_043812_0_0_1; -.
DR OMA; HHHKGAQ; -.
DR OrthoDB; 609735at2759; -.
DR TreeFam; TF314105; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0030276; F:clathrin binding; IEA:Ensembl.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0030295; F:protein kinase activator activity; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0045839; P:negative regulation of mitotic nuclear division; IEA:Ensembl.
DR GO; GO:0031954; P:positive regulation of protein autophosphorylation; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0007165; P:signal transduction; IEA:Ensembl.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR014645; TOM1.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR13856:SF28; TOM1-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR13856; VHS DOMAIN CONTAINING PROTEIN FAMILY; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR PIRSF; PIRSF036948; TOM1; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR036948};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR036948}.
FT DOMAIN 22..154
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 201..289
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT REGION 154..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 474 AA; 52867 MW; 88D9B9F2F441FF06 CRC64;
MAFGKSQKDP FGTAVGHLIE RATVGTLPAE EWGLFMHICD FINTTEEGPK DAVKALKKRI
SKNCNHKEIR FTLSLLDMCM TNCGSSFRAL VVKKDFCKDK LVKLLNPRYN LPTEMQEKIL
AFIRTWSYEF QGIVDVSEVK EVYLELLKKG VQFPSSDANS GTQKQQASSW PSEKPLPPST
ASVKSIAVPH PPVPTITLTP EQAGKIYSEL DMAKMNTKVM SEILKENVPG CENLDDMVLL
QKLYKTCRVM QERIVELLLA VQNEDVVAEL IQVNEELNNV LLGHERFSRN RVRFLENQRI
QREHTEIYSK QPSAPSCDLL DINSSSSFPM SALVGNGPET PQFSKLNCRS TSATEPSNHH
PLLYPQLNLL ATANAQQPSF ATEPQSTSQN LPGGQTYQNL ATVLNPVPLQ TVNLQTVNAS
SQNEAPSDMS KSSSQAPHYY EVMEFDPLAP SYGTEAIYEE IDDYISKSEV KGQC
//
