ID K7GA50_PELSI Unreviewed; 364 AA.
AC K7GA50;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Snurportin-1 {ECO:0000256|ARBA:ARBA00016034, ECO:0000256|PIRNR:PIRNR037955};
DE AltName: Full=RNA U transporter 1 {ECO:0000256|ARBA:ARBA00031454, ECO:0000256|PIRNR:PIRNR037955};
GN Name=SNUPN {ECO:0000313|Ensembl:ENSPSIP00000017161.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000017161.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000017161.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions as an U snRNP-specific nuclear import adapter.
CC Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import
CC of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
CC {ECO:0000256|ARBA:ARBA00003975, ECO:0000256|PIRNR:PIRNR037955}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR037955}.
CC -!- SIMILARITY: Belongs to the snurportin family.
CC {ECO:0000256|ARBA:ARBA00007540, ECO:0000256|PIRNR:PIRNR037955}.
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DR EMBL; AGCU01107667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01107668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01107669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01107670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01107671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006126313.1; XM_006126251.2.
DR RefSeq; XP_006126314.1; XM_006126252.2.
DR RefSeq; XP_006126315.1; XM_006126253.2.
DR AlphaFoldDB; K7GA50; -.
DR Ensembl; ENSPSIT00000017239.1; ENSPSIP00000017161.1; ENSPSIG00000015229.1.
DR GeneID; 102450719; -.
DR KEGG; pss:102450719; -.
DR CTD; 10073; -.
DR GeneTree; ENSGT00510000047494; -.
DR HOGENOM; CLU_056809_0_0_1; -.
DR OMA; VQLSEWM; -.
DR OrthoDB; 197726at2759; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006606; P:protein import into nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0061015; P:snRNA import into nucleus; IEA:UniProtKB-UniRule.
DR CDD; cd09232; Snurportin-1_C; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR017336; Snurportin-1.
DR InterPro; IPR024721; Snurportin-1_N.
DR InterPro; IPR047857; Snurportin1_C.
DR PANTHER; PTHR13403:SF6; SNURPORTIN-1; 1.
DR PANTHER; PTHR13403; SNURPORTIN1 RNUT1 PROTEIN RNA, U TRANSPORTER 1; 1.
DR Pfam; PF11538; Snurportin1; 1.
DR PIRSF; PIRSF037955; Snurportin-1; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR037955};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PIRNR:PIRNR037955};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037955}.
FT DOMAIN 11..73
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT SITE 105
FT /note="Interaction with m3G-cap structure"
FT /evidence="ECO:0000256|PIRSR:PIRSR037955-1"
FT SITE 144
FT /note="Interaction with m3G-cap structure"
FT /evidence="ECO:0000256|PIRSR:PIRSR037955-1"
FT SITE 277
FT /note="Interaction with m3G-cap structure"
FT /evidence="ECO:0000256|PIRSR:PIRSR037955-1"
SQ SEQUENCE 364 AA; 41137 MW; BB5ED0DD096A5A45 CRC64;
MEELNQALAS SFAVSPDLNS IAAPHPRLAQ YKSKYSSLEQ AERRRKLLEL QKSKRLDYVN
HARRLAEDDW TGAEAEEGED AGNEDMDVDL VKKLPKRYAN QLMLSEWLID VPPDLEQEWI
LVVSPIGKRA LIVAARGSTA AYTKSGFCVN RFPSLLPGGN RRTSATGKDY TILDCIYSEV
NQTYYILDVM CWRGHPVYDC QTDFRFYWLH SKIQEEEGLA EKSRINPFKF VGLQSFPCTP
ESLCKVLAMD FPFEVDGLLF YHKQTHYSPG STPLVGWLRP YMVSDILGMT VPANPLTTKP
DYAGHQLQQI IEHKKSKKLA GEEGCLSTTK EMAENGRYEL EHLSTPCVAD APNSQVETAS
QMQN
//
