ID K7GCF6_PELSI Unreviewed; 616 AA.
AC K7GCF6;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Rho GTPase activating protein 22 {ECO:0000313|Ensembl:ENSPSIP00000017967.1};
GN Name=ARHGAP22 {ECO:0000313|Ensembl:ENSPSIP00000017967.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000017967.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000017967.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01052476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01052477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01052478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01052479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01052480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01052481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01052482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01052483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01052484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01052485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7GCF6; -.
DR STRING; 13735.ENSPSIP00000017967; -.
DR Ensembl; ENSPSIT00000018050.1; ENSPSIP00000017967.1; ENSPSIG00000015929.1.
DR eggNOG; KOG4270; Eukaryota.
DR GeneTree; ENSGT00950000183015; -.
DR OMA; MAVNHEA; -.
DR TreeFam; TF323577; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0099175; P:regulation of postsynapse organization; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04390; RhoGAP_ARHGAP22_24_25; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228:SF22; RHO GTPASE-ACTIVATING PROTEIN 22; 1.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 1..55
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 65..259
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 287..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 525..601
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 300..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 616 AA; 68116 MW; 0FDC98A432218A7F CRC64;
MPFFTAKYLK KSKCLRKGGT GDREKVPVNH EAFLLMANSQ NEMEDWVKAI RRVIWAPFGG
GIFGQRLEDT VQYERKYGLR LAPLLVEQCV DFIRERGLTE EGLFRMPGQA NLVKDLQDSF
DCGEKPLFDS NTDVHTVASL LKLYLRELPE PVIPFAKYED FLSCGQLLSK DKGEGTRELA
KQVKTLPQAN YNLLKYICKF LDEVQSHSTV NKMSVQNLAT VFGPNILRPK MEDPVTIMEG
TSLVQHLMTV LISEHGRIFA VSQADVAGAP PEARSVLQRS MVEWISEEEG EESRLEKSGP
SPASLPSSSA VAPDTTRSSL AKNASQERSS RASQPATSPS KRVQTLPTWK YSFRQQGARS
VSPKLGNSSL DIPNLPSSGN WLMNGLYSLR GHRRTSSGER GKDSGSSQRL STYDNVPSSS
LSLSAHSIAS TAWSASSCEI SVVDSVSSCP ACRASDSSTL SSLKTEWATQ GSLSQSEVKP
ADLESSAERF EMCVSSCSEQ SNLAAASKDS AKCSRALQSL VSELKTELSK QRTEYESSIK
RIEAASAELR KQVARLEEEL DQERKKYTML EIKLRNSERA REDAEKRNQL LQTEMEEFFS
TLGNLTAASR GAKVPK
//
