ID K7GCQ9_PELSI Unreviewed; 711 AA.
AC K7GCQ9;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=RNA binding motif protein 5 {ECO:0000313|Ensembl:ENSPSIP00000018070.1};
GN Name=RBM5 {ECO:0000313|Ensembl:ENSPSIP00000018070.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000018070.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000018070.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AGCU01061323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01061324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01061325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014427270.1; XM_014571784.1.
DR RefSeq; XP_014427272.1; XM_014571786.1.
DR AlphaFoldDB; K7GCQ9; -.
DR STRING; 13735.ENSPSIP00000018070; -.
DR Ensembl; ENSPSIT00000018154.1; ENSPSIP00000018070.1; ENSPSIG00000016073.1.
DR GeneID; 102458515; -.
DR CTD; 10181; -.
DR eggNOG; KOG0154; Eukaryota.
DR GeneTree; ENSGT00940000156617; -.
DR HOGENOM; CLU_010527_0_0_1; -.
DR OMA; CESEHER; -.
DR OrthoDB; 298711at2759; -.
DR TreeFam; TF315789; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003729; F:mRNA binding; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:Ensembl.
DR GO; GO:0000245; P:spliceosomal complex assembly; IEA:Ensembl.
DR CDD; cd16168; OCRE_RBM5; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 1.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR041591; OCRE.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR13948; RNA-BINDING PROTEIN; 1.
DR PANTHER; PTHR13948:SF21; RNA-BINDING PROTEIN 5; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF17780; OCRE; 1.
DR Pfam; PF00076; RRM_1; 2.
DR Pfam; PF00641; zf-RanBP; 1.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00360; RRM; 2.
DR SMART; SM00547; ZnF_RBZ; 1.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50174; G_PATCH; 1.
DR PROSITE; PS50102; RRM; 2.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022728};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00022728};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; Spliceosome {ECO:0000256|ARBA:ARBA00022728};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT DOMAIN 1..78
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 81..110
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 131..215
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 543..573
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 639..685
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT REGION 315..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 513..543
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 315..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..437
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 711 AA; 80027 MW; 788D063BF6AD89D2 CRC64;
MLRGLPITVT ENDIRELIES FEGPQPADVR LMKRKTGVSR GFAFVEFYHF QDATSWMEAN
QKKLVIQGKQ IAMHYSNPRP KFEDWLCSKC LLYNFRRRLK CFRCGADKFD SEQEVPPGSA
EAVQSVDYYC DTIILRNIAP HTVVDSIMTA LSPYASLAVN NIRLIKDKQT QQNRGFAFVQ
LSSAMDASQL LQILQSLQPP LKIDGKTIGV DFAKSARKDL LLPDGNRISA FSVASTAIAA
AQWSSTQPQS GEGGTIDYSY LQPGQEGYSQ YAQYSQDYQQ YYQSQAGALD TEAATISGAP
VTTTTAAVVS QSPQLYNQQP NSPDSPTQPA QPSTSTQVQS TAPVGVVPGT KYAVPDTSTY
QYDESSGYYY DPITGLYYDP NSQYYYNALT QQYLYWDGEK ETYMPAAEGI SYQQTSVSGK
EGKEKKEKPK SKTAQQIAKD MERWAKSLNK QKENFKNSFQ PLCSREEERR ESAAADAGFA
LFEKKGTLSE RQQVMPEVVK NGEEENPLKR GLVAAYSGDS DNEEDLLERI ENEEEKLTDW
KKLACLLCRR QFPNKDALVR HQQLSDLHKQ NMDIYRRSRL SEQELEALEL REREMKYRDR
AAERREKYGI PEPPEPKRKK VFDAGTVNYE QPTKDGIDHS NIGNKMLQAM GWREGSGLGR
KCQGITAPIE AQVRMRGAGL GAKGSSYGVS TADSYKDAVR KAMFARFTEM E
//
