ID K7GD94_PELSI Unreviewed; 1203 AA.
AC K7GD94;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Tubulin-specific chaperone D {ECO:0000256|ARBA:ARBA00015003};
GN Name=TBCD {ECO:0000313|Ensembl:ENSPSIP00000018255.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000018255.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000018255.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TBCD family.
CC {ECO:0000256|ARBA:ARBA00006853}.
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DR EMBL; AGCU01056393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01056394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01056395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01056396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01056397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01056398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01056399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01056400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01056401; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01056402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7GD94; -.
DR STRING; 13735.ENSPSIP00000018255; -.
DR Ensembl; ENSPSIT00000018340.1; ENSPSIP00000018255.1; ENSPSIG00000016017.1.
DR eggNOG; KOG1943; Eukaryota.
DR GeneTree; ENSGT00390000017103; -.
DR OMA; EPHEAWH; -.
DR TreeFam; TF105754; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0048487; F:beta-tubulin binding; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0048667; P:cell morphogenesis involved in neuron differentiation; IEA:Ensembl.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0031115; P:negative regulation of microtubule polymerization; IEA:Ensembl.
DR GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IEA:Ensembl.
DR GO; GO:0007021; P:tubulin complex assembly; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR033162; TBCD.
DR InterPro; IPR022577; Tubulin_specific_chaperoneD_C.
DR PANTHER; PTHR12658; BETA-TUBULIN COFACTOR D; 1.
DR PANTHER; PTHR12658:SF0; TUBULIN-SPECIFIC CHAPERONE D; 1.
DR Pfam; PF12612; TFCD_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 910..1098
FT /note="Tubulin-specific chaperone D C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12612"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1203 AA; 135413 MW; 9FD575817DD8318B CRC64;
MALSEMEGDG SEEEQSGCQE PDVIASGNIL ESFTESQEIR GLINNLRGVY GDQGTREVTT
EKFIVIMDKY QEQPHLLDSH LEWMMHLLLD IVRDNSSPSP LVHLAFKFLY IITKVRGYKI
FLQLFPHEVA DVQPVLDMFA DQNPKDYETW ETRYMLLLWL SMTCLIPFDL ARLDGNILSE
GHTRMPIMDR ILKIAKSYLV VSDKARDAAA VLVSRFITRP DVKQKRMANF LDWALSTLSK
SSFQTMEGTI VMDGMLQALA QLFKHGKRDD CLPYASTVLE CLDNCKLSES NQTLLRKLGV
KLVQRLGLTF LKPKVAKWRY QRGCRSLATN LQFSGQGAVA QNLVTAAVAA AADVEEEYDI
PGEVENVIEQ LLVGLKDKDT IVRWSAAKGV GRITGRLPKE LADDVVGSLL DCFSFQETDN
SWHGGCLALA ELGRRGLLLP SRIVDVVPVI LKALTYDEKR GACSVGSNVR DAACYVCWAF
ARAYDPLELK PFVNQISSAL IIAAVFDRDI NCRRAASAAF QENVGRQGTF PHGIDILTAA
DYFAVGNRVN CFLNISVYIA SFPEYTQAMI DHLVNMKINH WDGVIRELST KALRNLTPQA
PEYMTNVVLP KLLPLAVGPD LHIRHGAILA CAEITHALYK LAAENNRSIT NYFDGKSLEG
LKQIHWELCS RQLYRGLGGE LMRPAVCTLI EKLSLSKMPF REDRIIAPEG WQWLINDSLR
SLPLVSSTTR QQIKEAAVSA LAALCNEYYS NEQREASPAL QGELLEQYIS ELQNTEEMIR
CGFSLALGAF PRFLLKGKLQ QVLQSLKKVT CISDKHVSFA ESRRDGLKAI AKVCQTVGVK
REGSQDEFVC KDNVVQIYTM LLNGMSDYTT DSRGDVGAWV REAAMTSLME VTLLLVQNEP
EMLDANICEQ IMCCLAQQSA EKIDRFRAHA GSVFLNFLYY DNPPVPHIPH REELERIFPR
SEAVTLNWNA PSQAFPRITQ LLGLPTYRYH VLLGLTVSVG GLTETTVRYS AQSLFDYMKK
IQNNPCAMNT FCETLLRVFE DNLLNDRLRV SVPLLKMLDQ MLANGCFDIF TTEENHPFAL
KLLTLCKEEI KKSKDIQKLR SSIAVFCGMI QFQGDMREKV LFQLFLLLCH PFPVIRKTAA
SQVYEMLITY SDIVDPDILD EVMTVLSDTS WDAELPLVRE KRNFLCDLMK VPKPQLVSKG
LCC
//
