ID K7GDA6_PELSI Unreviewed; 2389 AA.
AC K7GDA6;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Fibronectin {ECO:0000256|ARBA:ARBA00020368};
GN Name=FN1 {ECO:0000313|Ensembl:ENSPSIP00000018267.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000018267.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000018267.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01115502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01115507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 13735.ENSPSIP00000018267; -.
DR Ensembl; ENSPSIT00000018353.1; ENSPSIP00000018267.1; ENSPSIG00000015987.1.
DR eggNOG; ENOG502QPTS; Eukaryota.
DR GeneTree; ENSGT00940000155126; -.
DR HOGENOM; CLU_000916_0_0_1; -.
DR OMA; VHWLAPQ; -.
DR TreeFam; TF329915; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0005577; C:fibrinogen complex; IEA:Ensembl.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR GO; GO:0016504; F:peptidase activator activity; IEA:Ensembl.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0043394; F:proteoglycan binding; IEA:Ensembl.
DR GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR GO; GO:0051702; P:biological process involved in interaction with symbiont; IEA:Ensembl.
DR GO; GO:0007161; P:calcium-independent cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0007044; P:cell-substrate junction assembly; IEA:Ensembl.
DR GO; GO:0035987; P:endodermal cell differentiation; IEA:Ensembl.
DR GO; GO:0033622; P:integrin activation; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0150102; P:negative regulation of monocyte activation; IEA:Ensembl.
DR GO; GO:0071635; P:negative regulation of transforming growth factor beta production; IEA:Ensembl.
DR GO; GO:1901166; P:neural crest cell migration involved in autonomic nervous system development; IEA:Ensembl.
DR GO; GO:0045773; P:positive regulation of axon extension; IEA:Ensembl.
DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:1904237; P:positive regulation of substrate-dependent cell migration, cell attachment to substrate; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0034446; P:substrate adhesion-dependent cell spreading; IEA:Ensembl.
DR GO; GO:0042060; P:wound healing; IEA:Ensembl.
DR CDD; cd00061; FN1; 12.
DR CDD; cd00062; FN2; 2.
DR CDD; cd00063; FN3; 16.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 12.
DR Gene3D; 2.10.10.10; Fibronectin, type II, collagen-binding; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 16.
DR InterPro; IPR000083; Fibronectin_type1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR000562; FN_type2_dom.
DR InterPro; IPR036943; FN_type2_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013806; Kringle-like.
DR PANTHER; PTHR46708:SF8; FIBRONECTIN; 1.
DR PANTHER; PTHR46708; TENASCIN; 1.
DR Pfam; PF00039; fn1; 11.
DR Pfam; PF00040; fn2; 2.
DR Pfam; PF00041; fn3; 16.
DR PRINTS; PR00013; FNTYPEII.
DR SMART; SM00058; FN1; 12.
DR SMART; SM00059; FN2; 2.
DR SMART; SM00060; FN3; 16.
DR SUPFAM; SSF49265; Fibronectin type III; 9.
DR SUPFAM; SSF57603; FnI-like domain; 12.
DR SUPFAM; SSF57440; Kringle-like; 2.
DR PROSITE; PS01253; FN1_1; 4.
DR PROSITE; PS51091; FN1_2; 11.
DR PROSITE; PS00023; FN2_1; 1.
DR PROSITE; PS51092; FN2_2; 2.
DR PROSITE; PS50853; FN3; 16.
PE 4: Predicted;
KW Acute phase {ECO:0000256|ARBA:ARBA00022486};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell shape {ECO:0000256|ARBA:ARBA00022960};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00479}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sulfation {ECO:0000256|ARBA:ARBA00022641}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..2389
FT /note="Fibronectin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003906418"
FT DOMAIN 49..89
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 94..142
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 137..180
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 182..226
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 227..271
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 353..401
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT DOMAIN 413..461
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT DOMAIN 466..509
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 514..556
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 557..600
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 608..701
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 719..809
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 810..901
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 908..997
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 998..1087
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1088..1174
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1175..1266
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1268..1360
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1361..1448
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1449..1542
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1543..1634
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1635..1722
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1723..1816
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1817..1903
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1904..1994
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2108..2200
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2207..2251
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 2252..2294
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 2296..2336
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT REGION 23..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1392..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1392..1406
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 358..384
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 372..399
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 418..444
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 432..459
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
SQ SEQUENCE 2389 AA; 263051 MW; 6503C7B2932B0150 CRC64;
MPSSPGWPLL LLALVVGAGA HGEQPRTTKA RRQAQQIAQP PVPSSQNKQG CYDNGRHYQI
NQQWERTYLG RMLVCTCYGG SRGFNCESKP ELEETCFDKY TGSTHRVGET YERPKDSMIW
DCTCIGAGRG RIATVAYRCH EGGQSYKIGD TWRRPHETGG YMLECVCLGN GKGEWTCKPV
AERCYDNTAG TSYVVGETWE KPYQGWMMVD CTCLGEGSGR ITCTSRNRCN DQDTTTSYRI
GDTWSKKDNR GNLLQCICTG NGRGEWKCER HSAVQTTGIG SGSPTFTDVR TALYQPQPQP
PPYGHCVTDS GVVYSIGMKW LKTQGSQQML CTCLGNGVSC QETAVTQTYG GNSNGEPCVL
PFTYGGRTFY SCTTEGRSDG HLWCSTTSNF EQDNKYSFCT EQNVLVQTRG GNSNGALCHF
PFLYNNRNYT DCTSEGRRDN MKWCGTTQNY DADQKFGFCP MAAHEEICTT NEGVMYRVGD
HWDKQHDMGH MMKCTCVGNG RGEWTCIAYS QLRDQCIVDG ITYDVNQTFH KRHEEGHMLN
CTCFGQGRGR WKCDPVDQCQ DSESRTFYQI GDSWEKHVHG VRYQCYCYGR GIGEWHCQPL
QAFPGATGPV QVIITESGSH PNSHPIQWNA PETSHISQYI LRWRPKNKRA LWKEAIIPGH
LNSYTISGLK PGVQYEGQLV SVQQYGPKEV TRFDFTTTHI TPISTNTLSG ETTPFSPVVA
TSESVTEITA SSFVVSWVSA SDTVSGFRVE YELSEEGAEP QYLDLPSTAT SVNIPDLLPG
RKYIVNVYQI SEEGEQNLIL STSQTTETAP DAPPEHNVDR VDDTSIVVSW SRPQAPITGY
RIVYTPSMEG SSTELNLPDT ATSVTLSDLM PGVQYNITIY AVEENQESTP VFIQQETTGV
PQKDDVPSPK DLQFVEVSDV KITIIWTPPS STVSGYRVDV IPVNRPGVHG QKLPVTRNYF
AEVTDLLPGT TYLFKVFTVL QGRESKPLTG EHTTKLDAPT NLRFENLTDS AVLVAWTPPR
APITGYQLTA GPTRGGQPKQ YNVVPSATNY QLKNLQPGSE YTVYLVALKG NQQSNRQTGI
FTTLQPMSSI PPYSTEVTET SIVVTWTPAP RIGFKLGVRP SQGGEAPREV TSESGSIVIS
GLTPGVEYVY SISVLMDGQD RDTPIVKRVT TPLSPPTNLH LEPNPDTGIL TVSWDRSTTP
GVTGYRVTTV PTSGQQGYTL EEVVSAEQTS CIFENLSPGL EYNVSVYSVQ DNKESIPISK
TITQAVPAPT DLRFTNVRPD TMRVTWTPPV SIELTSFLVR YSPVKKEDDV AELTISPSDN
MVVLTNLLPG TEYLVKVYSV YEQHESTALT GVQKTGLDSP TGIDFSDITA NSFTVHWIAP
RAAITGSKIR HHLEQGGGRP KEDRVPPSRN SITLTNLVPG SEYVVSIIAV NGKEESLPLV
GQQTTVSDVP RDVEVTATGP TSLVISWDAP AVTVRYYRIT YGETGGSGPI QEFTVPGTSS
TATISDLKPG ADYTITMYAV TGRGDSPASS KPVTVTYKTE IDTPSQLQVT DVQDNSISVR
WLPSTSPVTG YRVTTVPKDG HGPVKSKNVP ADQTQTTIEG LQPTVEYVVS VYAQSQNGES
LPLVETAITN IDRPRGLTFT EVDVDSIKIA WESPQGQVTS YRVTYSSPED GIRELVPAPD
GEDDTAELHG LRPGSEYTVT IVALHDDLES QPLTGTQSTA IPPPTNLQFV QVTPTSLKVN
WNAPSVRLTG YRVRVNPKEK TGPMKEINLS PDSTFAVVSG LMVATKYEVS VYALKDSLTS
TPAHGVVTTL ENISPPRRAR VTDATETTIT ITWRTKTETI TGFQVEAVPA DGQSPIQRTI
TPDVRTYTIT GLQPGTDYKI YLYTMNENAR SSPFVIDAST AIDAPSNLRF LTTTSNSQLI
TWQPPRAQIT GYIIKYERPG AQPKELIPRP RAGTTEATLT GLEPGIEYTI YIIAVKNAQK
SEPLVGRKKT DELPKLVTLP HPNQGGPEIL DVPSTVERTP YLTNRFDNGN GIQLPGTSGQ
QTLGNQGQQV FFEEHGFRRT TAPTTATPIR HRPGLQTPDV DEEIDLGNRY SIQRVDLVQP
SFPHSLGPRR NDTTGQEALS QTTISWRPLL ESTEYVISCQ PVGTDEEPLQ FRVPGTSSSA
TLTGLTRGAT YNIIVEALKD RRRHKVLEEV VTVGNAVSEG VNQPSDDTCY DTYTGSFYSI
GEEWERLSDT GFKLWCQCLG FGSGHFRCDS SKWCHDNGVS YKIGEKWDRQ GETGQMMSCT
CLGNGKGEFK CDPHEATCYD DGKMYHVGEQ WQKEYLGAIC SCTCYGGQQG WRCDNCRRPG
AEAAPDGTAG HSYTQFSQRY HQSTNTNVNC PIECFMPLDV QADRQHRPG
//
