ID K7GE95_PELSI Unreviewed; 581 AA.
AC K7GE95;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=WSC domain containing 1 {ECO:0000313|Ensembl:ENSPSIP00000018606.1};
GN Name=WSCD1 {ECO:0000313|Ensembl:ENSPSIP00000018606.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000018606.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000018606.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at
CC the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
CC as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.
CC {ECO:0000256|ARBA:ARBA00035001}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the WSCD family.
CC {ECO:0000256|ARBA:ARBA00010236}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGCU01199102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01199103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01199104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01199105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006138625.1; XM_006138563.2.
DR AlphaFoldDB; K7GE95; -.
DR Ensembl; ENSPSIT00000018692.1; ENSPSIP00000018606.1; ENSPSIG00000016511.1.
DR GeneID; 102461868; -.
DR KEGG; pss:102461868; -.
DR CTD; 23302; -.
DR GeneTree; ENSGT00940000158096; -.
DR HOGENOM; CLU_029239_1_0_1; -.
DR OrthoDB; 3971278at2759; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR InterPro; IPR002889; WSC_carb-bd.
DR PANTHER; PTHR45964:SF5; WSC DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45964; WSCD FAMILY MEMBER CG9164; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR Pfam; PF01822; WSC; 2.
DR SMART; SM00321; WSC; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51212; WSC; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT DOMAIN 142..234
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
FT DOMAIN 245..340
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
SQ SEQUENCE 581 AA; 67248 MW; 64240226045408D8 CRC64;
MAKPFFRLQK FLRRTQFLLF FLTAAYLMAG SLLLLQRSRL AIQQGTRGTS NIQASPISDM
VVGVGILDAR TMQNPRLRAK LLMDMDELRH PTSDQRYGPR WLISRNSELR QLRRRWFHRF
INDQEPMQAM GSKVMPQTGE NKGTYVGCFS DDSREKTLKG AVFYDLRKMT VSHCQEACAE
RAYTYAGLEY GAECYCGNTL PVTIAKQEEC NNECKGEKGS ICGGVNRLSV YRVEELRAGA
KRRRNVIYRG CFRAPENLTV TFPASLIQSN LTVEKCSEFC SKKEFPLAVI GGPECYCGYP
TMHFTLHDSV DRLFCSRQQN VSSVAEVPRD ENYYQVYQTP VQDTRCTDRK FLTTKSKVFV
ALSSFPGAGN TWARHLIEHA TGYYTGSYYF DGTLYNKGFK GEKDHWRSRR TICVKTHESG
KREIEMFDSA ILLIRNPYKS LMAEFNRKCA GHLGYATDRN WKSKEWPDFV NSYASWWASH
VIDWLKYGKH LLVVHYEDLK QNLIPKLKEM VEFLNMTVTE DRLLCVENNR DGNFKRSGAR
QKDFEPFTQE MKDLINKYIL TVEEALKRRN LTGLPREYLP R
//
