GenomeNet

Database: UniProt
Entry: K7GFT5_PELSI
LinkDB: K7GFT5_PELSI
Original site: K7GFT5_PELSI 
ID   K7GFT5_PELSI            Unreviewed;      1435 AA.
AC   K7GFT5;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   08-NOV-2023, entry version 66.
DE   SubName: Full=FYVE, RhoGEF and PH domain containing 6 {ECO:0000313|Ensembl:ENSPSIP00000019146.1};
GN   Name=FGD6 {ECO:0000313|Ensembl:ENSPSIP00000019146.1};
OS   Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC   Trionychidae; Pelodiscus.
OX   NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000019146.1, ECO:0000313|Proteomes:UP000007267};
RN   [1] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG   Soft-shell Turtle Genome Consortium;
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA   White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA   Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA   Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA   Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT   into the development and evolution of the turtle-specific body plan.";
RL   Nat. Genet. 45:701-706(2013).
RN   [3] {ECO:0000313|Ensembl:ENSPSIP00000019146.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AGCU01053063; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01053064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01053065; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01053066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 13735.ENSPSIP00000019146; -.
DR   Ensembl; ENSPSIT00000019235.1; ENSPSIP00000019146.1; ENSPSIG00000016928.1.
DR   eggNOG; KOG1729; Eukaryota.
DR   GeneTree; ENSGT00940000156334; -.
DR   HOGENOM; CLU_004959_0_0_1; -.
DR   OMA; ERTDKPC; -.
DR   TreeFam; TF343077; -.
DR   Proteomes; UP000007267; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd15743; FYVE_FGD6; 1.
DR   CDD; cd15793; PH1_FGD6; 1.
DR   CDD; cd13237; PH2_FGD5_FGD6; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR037743; FGD6_N_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000306; Znf_FYVE.
DR   InterPro; IPR017455; Znf_FYVE-rel.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR   PANTHER; PTHR12673:SF12; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 6; 1.
DR   Pfam; PF01363; FYVE; 1.
DR   Pfam; PF00169; PH; 2.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00064; FYVE; 1.
DR   SMART; SM00233; PH; 2.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
DR   PROSITE; PS50178; ZF_FYVE; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00091}.
FT   DOMAIN          876..1065
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          1094..1188
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          1227..1286
FT                   /note="FYVE-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50178"
FT   DOMAIN          1338..1434
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          78..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          211..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          477..503
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          603..627
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          685..735
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          801..873
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1201..1221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..250
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        480..500
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        610..627
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        801..834
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        840..854
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        855..873
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1435 AA;  161145 MW;  D4F1C9F9C64C85E5 CRC64;
     CFSFLEIKKP PVAPKPKFVV GYKSSPPPVA PKPDIVLAGV VQTIKKTKPA IAPKPKVLKS
     SSVPEVRPPS CLRKCTKSLE EHTGESSETL DHLNFENGDP AENTEDTAYI IPMCSCDFEC
     IHKLGNGEST CNTQIIFEHL ENLENIKIGG QIAPSVKSRT INENHNEKVA NRNRVVLKGS
     FLEGTLKDVL TQSIFPTSNL LRHECPDKLE RDDCDSSNNE KEFTNLAPSS GSEESAVKPQ
     NNHNKGDAND IHMTETCSSL TEKNHNCCCS LDQVTLENIN VKSDITFSGE VCMKGDDVKT
     PPSSIVCSVS VSKVLPVPKP RKPRTACLVR QDGIDTTGEV TREPINSESD CAGPSEHILK
     KPATINVLGQ SVSYNDNPEK VLQNNTFEIT QNLELTSQDI SPQVLQEASL MTENVEHSLD
     EDLNLKSPAD KMTDDASMLA AVDKRISFIR SSTLSMSLPK QLKLSCNQDL VPSSSLHISS
     QTREHKEIHV KDESSPRIIP KKPQRHSLPA AGLLKKAASE ELVEKSSYIS NEDKKSEKVL
     DRTCLRHMLA NEQGTLSYHG MPKRSSEKPV WKLPHPILPF SGNPDSLKTA NVATNSDFST
     AVTKPRAKSL SSVDMERTNK SSKDTQKKNA LKKLLNIKLS VCIMKSDFQK FFSKGSQSMD
     SAIASFSTEE GNSVGNNWNV TSIASERKTK SARARSIEIG SPASQKKRQR HRSHHEIPNS
     RRVESLDEHT FSGKQLSQTH LNSLISDYPP DYENVQHYEE IPEYENLPFI LSSDKNPCFE
     WQNSSSVVED HDSNVYEVEE PYEAASSHSR HGRKDDKNTN RASDHSDHNA MLGDIQSDEE
     IINSSDEEDD TNSDSSKGEL DLQEEKQGKA SGKKTKVYHI AKEIMSSEKV FVDVLKLLHI
     DFRDAVAHAS RQLGKPVIED RILNQILYYL PQLYELNRDL LRELEERLSH WIDHQRIADI
     FVKKGPYLKM YSTYIKEFDK NVALLDEQCK KNPSFAAVVK DFEMSPRCAS LALKHYLLKP
     VQRIPQYRLL LTDYLKNLLE DSADYRDTQG ALAVVIEVAN HANDIMKQGD NFQKLMQIQY
     SLNGHHEIVQ PGRVFLKEGT LMKLSRKVMQ PRVFFLFNDA LLYTTPVQSG MYKLNNMLSL
     AGMKVRKPTQ EAYQNELNIE SVERSFILSA SSATERDEWL EAISRSIEEY TKKRITFNPS
     KSLEEADPEK EEGGSPLGSK APIWVPDTRA TMCMICTSEF TLTWRRHHCR ACGKIICQAC
     STNKHGLDYM KNQPARVCDH CFKELQKQDN QFTPKSGSPV NHKSPSSALS TVLHSIPSGR
     KQKKITAALK EVSANTEDSS MSGYLYRSKG SKKPWKHLWF VIKNKVLYTY AASEDVAALE
     SQPLLGFTVS EVKDENSESK VFHLLHKNTL FYIFKADDSH SAQKWIEAFQ EGTIL
//
DBGET integrated database retrieval system