ID K7GFT5_PELSI Unreviewed; 1435 AA.
AC K7GFT5;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 08-NOV-2023, entry version 66.
DE SubName: Full=FYVE, RhoGEF and PH domain containing 6 {ECO:0000313|Ensembl:ENSPSIP00000019146.1};
GN Name=FGD6 {ECO:0000313|Ensembl:ENSPSIP00000019146.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000019146.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000019146.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; AGCU01053063; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01053064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01053065; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01053066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 13735.ENSPSIP00000019146; -.
DR Ensembl; ENSPSIT00000019235.1; ENSPSIP00000019146.1; ENSPSIG00000016928.1.
DR eggNOG; KOG1729; Eukaryota.
DR GeneTree; ENSGT00940000156334; -.
DR HOGENOM; CLU_004959_0_0_1; -.
DR OMA; ERTDKPC; -.
DR TreeFam; TF343077; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15743; FYVE_FGD6; 1.
DR CDD; cd15793; PH1_FGD6; 1.
DR CDD; cd13237; PH2_FGD5_FGD6; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR037743; FGD6_N_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF12; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 6; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 876..1065
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1094..1188
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1227..1286
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 1338..1434
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 78..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1201..1221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..500
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..627
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 801..834
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..854
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 855..873
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1435 AA; 161145 MW; D4F1C9F9C64C85E5 CRC64;
CFSFLEIKKP PVAPKPKFVV GYKSSPPPVA PKPDIVLAGV VQTIKKTKPA IAPKPKVLKS
SSVPEVRPPS CLRKCTKSLE EHTGESSETL DHLNFENGDP AENTEDTAYI IPMCSCDFEC
IHKLGNGEST CNTQIIFEHL ENLENIKIGG QIAPSVKSRT INENHNEKVA NRNRVVLKGS
FLEGTLKDVL TQSIFPTSNL LRHECPDKLE RDDCDSSNNE KEFTNLAPSS GSEESAVKPQ
NNHNKGDAND IHMTETCSSL TEKNHNCCCS LDQVTLENIN VKSDITFSGE VCMKGDDVKT
PPSSIVCSVS VSKVLPVPKP RKPRTACLVR QDGIDTTGEV TREPINSESD CAGPSEHILK
KPATINVLGQ SVSYNDNPEK VLQNNTFEIT QNLELTSQDI SPQVLQEASL MTENVEHSLD
EDLNLKSPAD KMTDDASMLA AVDKRISFIR SSTLSMSLPK QLKLSCNQDL VPSSSLHISS
QTREHKEIHV KDESSPRIIP KKPQRHSLPA AGLLKKAASE ELVEKSSYIS NEDKKSEKVL
DRTCLRHMLA NEQGTLSYHG MPKRSSEKPV WKLPHPILPF SGNPDSLKTA NVATNSDFST
AVTKPRAKSL SSVDMERTNK SSKDTQKKNA LKKLLNIKLS VCIMKSDFQK FFSKGSQSMD
SAIASFSTEE GNSVGNNWNV TSIASERKTK SARARSIEIG SPASQKKRQR HRSHHEIPNS
RRVESLDEHT FSGKQLSQTH LNSLISDYPP DYENVQHYEE IPEYENLPFI LSSDKNPCFE
WQNSSSVVED HDSNVYEVEE PYEAASSHSR HGRKDDKNTN RASDHSDHNA MLGDIQSDEE
IINSSDEEDD TNSDSSKGEL DLQEEKQGKA SGKKTKVYHI AKEIMSSEKV FVDVLKLLHI
DFRDAVAHAS RQLGKPVIED RILNQILYYL PQLYELNRDL LRELEERLSH WIDHQRIADI
FVKKGPYLKM YSTYIKEFDK NVALLDEQCK KNPSFAAVVK DFEMSPRCAS LALKHYLLKP
VQRIPQYRLL LTDYLKNLLE DSADYRDTQG ALAVVIEVAN HANDIMKQGD NFQKLMQIQY
SLNGHHEIVQ PGRVFLKEGT LMKLSRKVMQ PRVFFLFNDA LLYTTPVQSG MYKLNNMLSL
AGMKVRKPTQ EAYQNELNIE SVERSFILSA SSATERDEWL EAISRSIEEY TKKRITFNPS
KSLEEADPEK EEGGSPLGSK APIWVPDTRA TMCMICTSEF TLTWRRHHCR ACGKIICQAC
STNKHGLDYM KNQPARVCDH CFKELQKQDN QFTPKSGSPV NHKSPSSALS TVLHSIPSGR
KQKKITAALK EVSANTEDSS MSGYLYRSKG SKKPWKHLWF VIKNKVLYTY AASEDVAALE
SQPLLGFTVS EVKDENSESK VFHLLHKNTL FYIFKADDSH SAQKWIEAFQ EGTIL
//