ID K7GFZ2_PELSI Unreviewed; 877 AA.
AC K7GFZ2;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Metabotropic glutamate receptor 3 {ECO:0000256|ARBA:ARBA00020281};
GN Name=GRM3 {ECO:0000313|Ensembl:ENSPSIP00000019203.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000019203.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000019203.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: G-protein coupled receptor for glutamate. Ligand binding
CC causes a conformation change that triggers signaling via guanine
CC nucleotide-binding proteins (G proteins) and modulates the activity of
CC down-stream effectors. Signaling inhibits adenylate cyclase activity.
CC {ECO:0000256|ARBA:ARBA00025645}.
CC -!- SUBUNIT: Interacts with TAMALIN. {ECO:0000256|ARBA:ARBA00011150}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; AGCU01046351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01046352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01046353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01046354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01046355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01046356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01046357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01046358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01046359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01046360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006117188.1; XM_006117126.2.
DR RefSeq; XP_006117189.1; XM_006117127.2.
DR RefSeq; XP_006117190.1; XM_006117128.2.
DR RefSeq; XP_014425974.1; XM_014570488.1.
DR RefSeq; XP_014425976.1; XM_014570490.1.
DR AlphaFoldDB; K7GFZ2; -.
DR Ensembl; ENSPSIT00000019293.1; ENSPSIP00000019203.1; ENSPSIG00000017007.1.
DR GeneID; 102447321; -.
DR KEGG; pss:102447321; -.
DR CTD; 2913; -.
DR GeneTree; ENSGT01030000234595; -.
DR HOGENOM; CLU_005389_0_0_1; -.
DR OrthoDB; 5388627at2759; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15284; 7tmC_mGluR_group2; 1.
DR CDD; cd06375; PBP1_mGluR_groupII; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001234; GPCR_3_mGluR3.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF160; METABOTROPIC GLUTAMATE RECEPTOR 3; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01053; MTABOTROPC3R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..877
FT /note="Metabotropic glutamate receptor 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003906504"
FT TRANSMEM 573..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 612..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 735..754
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 766..788
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 794..818
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 574..840
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 877 AA; 98541 MW; 111DBFA167D41C9C CRC64;
MFTRLQMLVL ALLSKGVFLS LSDHNFLRKE IKIEGDLVLG GLFPINEKGT GTEECGRINE
DRGIQRLEAM LFAIDEINRD SYLLPGIKLG VHILDTCSRD TYALEQSLEF VRASLTKVDE
TEYMCPDGSY AIQENIPLLI AGVIGGSYSS VSIQVANLLR LFQIPQISYA STSAKLSDKS
RYDYFARTVP PDFYQAKAMA EILRFFNWTY VSTVASEGDY GETGIEAFEQ EARLRNICIA
TSEKVGRSNI RKSYDSVIRE LLQKPNARVV VLFMRSDDSR ELIAAANRFN VSFTWVASDG
WGAQESVVKG NEHVAYGAIT LELASHPVKE FDRYFQSLSP YNNNRNPWFR DFWEQKFQCS
LQNRKAHRKA CDKHLTINSS NYEQESKIMF VVNAVYAMAH ALHKMQRTLC PNTTKLCDAM
KLLDGKKLYK DYLLKVNFTA PFNPSNAADS VVKFDTYGDG IGRYNVFNFQ YIGDKYSYLK
VGHWAETLSL DVDSIHWSRN SIPTSQCSDP CAPNEMKSMQ PGDVCCWICI ACEPFEYLAD
EFTCADCGPG QWPSADLTGC YDLPEDYVKW EDAWAIGPVT IACLGFICTF MVAAVFIKHN
NTPLVKASGR ELCYILLFGV FLSYSMTFFF IAKPSPAICT LRRLGLGSSF SVCYAALLTK
TNCIARIFNG VKNGAQRPKF ISPSSQVVIC LSLILVQIVV VSVWLILESP GTRRYTLPEK
RETVILKCNV KDSSMLISLT YDVILVVLCT VYAFKTRKCP ENFNEAKFIG FTMYTTCIIW
LAFLPIFYVT SSDYRVQTTT MCISVSLSGF VVLGCLFAPK VHIILFQPQK NVVTHRLHLN
RFSVSGTGTT YSQSSASVYV PTVCNGREVL DSTTSSL
//
